-
1
-
-
0026743033
-
The thyrotropin receptor and the regulation of thyrocyte function and growth
-
Vassart G, Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 13:596-611
-
(1992)
Endocr Rev
, vol.13
, pp. 596-611
-
-
Vassart, G.1
Dumont, J.E.2
-
3
-
-
1542316313
-
Amolecular dissection of the glycoprotein hormone receptors
-
Vassart G, Pardo L, Costagliola S 2004Amolecular dissection of the glycoprotein hormone receptors. Trends Biochem Sci 29:119-126
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 119-126
-
-
Vassart, G.1
Pardo, L.2
Costagliola, S.3
-
4
-
-
0015428430
-
Autoregulation of the thyroid. Response to iodide excess and depletion
-
Ingbar SH 1972 Autoregulation of the thyroid. Response to iodide excess and depletion. Mayo Clin Proc 47:814-823
-
(1972)
Mayo Clin Proc
, vol.47
, pp. 814-823
-
-
Ingbar, S.H.1
-
5
-
-
0001966082
-
Abnormal responses in the assay of thyrotropins
-
Adams DD, Purves HD 1956 Abnormal responses in the assay of thyrotropins. Proc Univ Otago Med Sch 34:11-12
-
(1956)
Proc Univ Otago Med Sch
, vol.34
, pp. 11-12
-
-
Adams, D.D.1
Purves, H.D.2
-
6
-
-
0000177574
-
Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema
-
Kriss JP, Pleshakov V, Chien JR 1964 Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J Clin Endocrinol Metab 24:1005-1028
-
(1964)
J Clin Endocrinol Metab
, vol.24
, pp. 1005-1028
-
-
Kriss, J.P.1
Pleshakov, V.2
Chien, J.R.3
-
8
-
-
34249941108
-
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
-
Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, Richards T, Powell M, Miguel RN, Blundell TL, Furmaniak J, Smith BR 2007 Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid 17:395-410
-
(2007)
Thyroid
, vol.17
, pp. 395-410
-
-
Sanders, J.1
Chirgadze, D.Y.2
Sanders, P.3
Baker, S.4
Sullivan, A.5
Bhardwaja, A.6
Bolton, J.7
Reeve, M.8
Nakatake, N.9
Evans, M.10
Richards, T.11
Powell, M.12
Miguel, R.N.13
Blundell, T.L.14
Furmaniak, J.15
Smith, B.R.16
-
9
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M 2000 Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289:739-745
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
10
-
-
36248970132
-
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
-
Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK 2007 Crystal structure of the human β2 adrenergic G-protein-coupled receptor. Nature 450: 383-387
-
(2007)
Nature
, vol.450
, pp. 383-387
-
-
Rasmussen, S.G.1
Choi, H.J.2
Rosenbaum, D.M.3
Kobilka, T.S.4
Thian, F.S.5
Edwards, P.C.6
Burghammer, M.7
Ratnala, V.R.8
Sanishvili, R.9
Fischetti, R.F.10
Schertler, G.F.11
Weis, W.I.12
Kobilka, B.K.13
-
11
-
-
36448978229
-
GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function
-
Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK 2007 GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function. Science 318:1266-1273
-
(2007)
Science
, vol.318
, pp. 1266-1273
-
-
Rosenbaum, D.M.1
Cherezov, V.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Yao, X.J.8
Weis, W.I.9
Stevens, R.C.10
Kobilka, B.K.11
-
12
-
-
36448995359
-
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
-
Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC 2007 High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor. Science 318:1258-1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
13
-
-
56749103466
-
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
-
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC 2008 The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322:1211-1217
-
(2008)
Science
, vol.322
, pp. 1211-1217
-
-
Jaakola, V.P.1
Griffith, M.T.2
Hanson, M.A.3
Cherezov, V.4
Chien, E.Y.5
Lane, J.R.6
Ijzerman, A.P.7
Stevens, R.C.8
-
14
-
-
7244221618
-
Model of glycoprotein hormone receptor ligand binding and signaling
-
Moyle WR, Xing Y, Lin W, Cao D, Myers RV, Kerrigan JE, Bernard MP 2004 Model of glycoprotein hormone receptor ligand binding and signaling. J Biol Chem 279:44442-44459
-
(2004)
J Biol Chem
, vol.279
, pp. 44442-44459
-
-
Moyle, W.R.1
Xing, Y.2
Lin, W.3
Cao, D.4
Myers, R.V.5
Kerrigan, J.E.6
Bernard, M.P.7
-
15
-
-
0025969701
-
Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for TSH receptor function
-
Nagayama Y, Wadsworth HL, Chazenbalk GD, Russo D, Seto P, Rapoport B 1991 Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for TSH receptor function. Proc Natl Acad Sci USA 88:902-905
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 902-905
-
-
Nagayama, Y.1
Wadsworth, H.L.2
Chazenbalk, G.D.3
Russo, D.4
Seto, P.5
Rapoport, B.6
-
16
-
-
0026706215
-
Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction
-
Nagayama Y, Rapoport B 1992 Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction. Endocrinology 131:548-552
-
(1992)
Endocrinology
, vol.131
, pp. 548-552
-
-
Nagayama, Y.1
Rapoport, B.2
-
17
-
-
59649083809
-
Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization
-
Misharin A, Hewison M, Chen CR, Lagishetty V, Aliesky HA, Mizutori Y, Rapoport B, McLachlan SM 2009 Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology 150:1051-1060
-
(2009)
Endocrinology
, vol.150
, pp. 1051-1060
-
-
Misharin, A.1
Hewison, M.2
Chen, C.R.3
Lagishetty, V.4
Aliesky, H.A.5
Mizutori, Y.6
Rapoport, B.7
McLachlan, S.M.8
-
18
-
-
0029054873
-
The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding
-
Gu WX, Du GG, Kopp P, Rentoumis A, Albanese C, Kohn LD, Madison LD, Jameson JL 1995 The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding. Endocrinology 136:3146-3153
-
(1995)
Endocrinology
, vol.136
, pp. 3146-3153
-
-
Gu, W.X.1
Du, G.G.2
Kopp, P.3
Rentoumis, A.4
Albanese, C.5
Kohn, L.D.6
Madison, L.D.7
Jameson, J.L.8
-
19
-
-
0028127807
-
Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse
-
Stein SA, Oates EL, Hall CR, Grumbles RM, Fernandez LM, Taylor NA, Puett D, Jin S 1994 Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. Mol Endocrinol 8:129-138
-
(1994)
Mol Endocrinol
, vol.8
, pp. 129-138
-
-
Stein, S.A.1
Oates, E.L.2
Hall, C.R.3
Grumbles, R.M.4
Fernandez, L.M.5
Taylor, N.A.6
Puett, D.7
Jin, S.8
-
20
-
-
0024852495
-
Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
-
Nagayama Y, Kaufman KD, Seto P, Rapoport B 1989 Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 165: 1184-1190
-
(1989)
Biochem Biophys Res Commun
, vol.165
, pp. 1184-1190
-
-
Nagayama, Y.1
Kaufman, K.D.2
Seto, P.3
Rapoport, B.4
-
21
-
-
43049109876
-
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction
-
Mizutori Y, Chen CR, McLachlan SM, Rapoport B 2008 The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. Mol Endocrinol 22:1171-1182
-
(2008)
Mol Endocrinol
, vol.22
, pp. 1171-1182
-
-
Mizutori, Y.1
Chen, C.R.2
McLachlan, S.M.3
Rapoport, B.4
-
22
-
-
0026002412
-
Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains
-
Kosugi S, Ban T, Akamizu T, Kohn LD 1991 Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains. J Biol Chem 266: 19413-19418
-
(1991)
J Biol Chem
, vol.266
, pp. 19413-19418
-
-
Kosugi, S.1
Ban, T.2
Akamizu, T.3
Kohn, L.D.4
-
23
-
-
0037084011
-
Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
-
Costagliola S, Panneels V, Bonomi M, Koch J, Many MC, Smits G, Vassart G 2002 Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors. EMBO J 21:504-513
-
(2002)
EMBO J
, vol.21
, pp. 504-513
-
-
Costagliola, S.1
Panneels, V.2
Bonomi, M.3
Koch, J.4
Many, M.C.5
Smits, G.6
Vassart, G.7
-
24
-
-
27844482098
-
A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling
-
Claus M, Jaeschke H, Kleinau G, Neumann S, Krause G, Paschke R 2005 A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. Endocrinology 146:5197-5203
-
(2005)
Endocrinology
, vol.146
, pp. 5197-5203
-
-
Claus, M.1
Jaeschke, H.2
Kleinau, G.3
Neumann, S.4
Krause, G.5
Paschke, R.6
-
25
-
-
33846978093
-
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor
-
Kleinau G, Claus M, Jaeschke H, Mueller S, Neumann S, Paschke R, Krause G 2007 Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor. J Biol Chem 282:518-525
-
(2007)
J Biol Chem
, vol.282
, pp. 518-525
-
-
Kleinau, G.1
Claus, M.2
Jaeschke, H.3
Mueller, S.4
Neumann, S.5
Paschke, R.6
Krause, G.7
-
26
-
-
10544240361
-
Four families with loss of function mutations of the thyrotropin receptor
-
de Roux N, Misrahi M, Brauner R, Houang M, Carel JC, Granier M, Le Bouc Y, Ghinea N, Boumedienne A, Toublanc JE, Milgrom E 1996 Four families with loss of function mutations of the thyrotropin receptor. J Clin Endocrinol Metab 81:4229-4235
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 4229-4235
-
-
De Roux, N.1
Misrahi, M.2
Brauner, R.3
Houang, M.4
Carel, J.C.5
Granier, M.6
Le Bouc, Y.7
Ghinea, N.8
Boumedienne, A.9
Toublanc, J.E.10
Milgrom, E.11
-
27
-
-
33845999291
-
Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor
-
Mueller S, Kleinau G, Jaeschke H, Neumann S, Krause G, Paschke R 2006 Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor. J Biol Chem 281:31638-31646
-
(2006)
J Biol Chem
, vol.281
, pp. 31638-31646
-
-
Mueller, S.1
Kleinau, G.2
Jaeschke, H.3
Neumann, S.4
Krause, G.5
Paschke, R.6
-
28
-
-
55749106015
-
FSH and TSH binding to their respective receptors: Similarities, differences and implication for glycoprotein hormone specificity
-
Núñez Miguel R, Sanders J, Chirgadze DY, Blundell TL, Furmaniak J, Rees Smith B 2008 FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. J Mol Endocrinol 41:145-164
-
(2008)
J Mol Endocrinol
, vol.41
, pp. 145-164
-
-
Núñez Miguel, R.1
Sanders, J.2
Chirgadze, D.Y.3
Blundell, T.L.4
Furmaniak, J.5
Rees Smith, B.6
-
29
-
-
67649361912
-
Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: A comparative structural study of protein-protein interactions
-
Núñez Miguel R, Sanders J, Chirgadze DY, Furmaniak J, Rees Smith B 2009 Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions. J Mol Endocrinol 42: 381-395
-
(2009)
J Mol Endocrinol
, vol.42
, pp. 381-395
-
-
Núñez Miguel, R.1
Sanders, J.2
Chirgadze, D.Y.3
Furmaniak, J.4
Rees Smith, B.5
-
30
-
-
33846156211
-
Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH
-
Sanders J, Bolton J, Sanders P, Jeffreys J, Nakatake N, Richards T, Evans M, Kiddie A, Summerhayes S, Roberts E, Miguel RN, Furmaniak J, Smith BR 2006 Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. Thyroid 16:1195-1206
-
(2006)
Thyroid
, vol.16
, pp. 1195-1206
-
-
Sanders, J.1
Bolton, J.2
Sanders, P.3
Jeffreys, J.4
Nakatake, N.5
Richards, T.6
Evans, M.7
Kiddie, A.8
Summerhayes, S.9
Roberts, E.10
Miguel, R.N.11
Furmaniak, J.12
Smith, B.R.13
-
31
-
-
0030752377
-
Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera
-
Chazenbalk GD, Jaume JC, McLachlan SM, Rapoport B 1997 Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera. J Biol Chem 272:18959-18965
-
(1997)
J Biol Chem
, vol.272
, pp. 18959-18965
-
-
Chazenbalk, G.D.1
Jaume, J.C.2
McLachlan, S.M.3
Rapoport, B.4
-
32
-
-
10944228424
-
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface
-
Kleinau G, Jäschke H, Neumann S, Lättig J, Paschke R, Krause G 2004 Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem 279:51590-51600
-
(2004)
J Biol Chem
, vol.279
, pp. 51590-51600
-
-
Kleinau, G.1
Jäschke, H.2
Neumann, S.3
Lättig, J.4
Paschke, R.5
Krause, G.6
-
33
-
-
49649125175
-
Extended hormone binding site of the human thyroid stimulating hormone receptor: Distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation
-
Mueller S, Kleinau G, Jaeschke H, Paschke R, Krause G 2008 Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem 283:18048-18055
-
(2008)
J Biol Chem
, vol.283
, pp. 18048-18055
-
-
Mueller, S.1
Kleinau, G.2
Jaeschke, H.3
Paschke, R.4
Krause, G.5
-
34
-
-
0038182549
-
Glycoprotein hormone receptors: Determinants in leucine-rich repeats responsible for ligand specificity
-
Smits G, Campillo M, Govaerts C, Janssens V, Richter C, Vassart G, Pardo L, Costagliola S 2003 Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity. EMBO J 22:2692-2703
-
(2003)
EMBO J
, vol.22
, pp. 2692-2703
-
-
Smits, G.1
Campillo, M.2
Govaerts, C.3
Janssens, V.4
Richter, C.5
Vassart, G.6
Pardo, L.7
Costagliola, S.8
-
35
-
-
33747864226
-
GRIS: Glycoprotein-hormone receptor information system
-
Van Durme J, Horn F, Costagliola S, Vriend G, Vassart G 2006 GRIS: glycoprotein-hormone receptor information system. Mol Endocrinol 20:2247-2255
-
(2006)
Mol Endocrinol
, vol.20
, pp. 2247-2255
-
-
Van Durme, J.1
Horn, F.2
Costagliola, S.3
Vriend, G.4
Vassart, G.5
-
36
-
-
11344254774
-
Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling
-
Núñez Miguel R, Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Blundell TL, Rees Smith B, Furmaniak J 2004 Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling. Thyroid 14:991-1011
-
(2004)
Thyroid
, vol.14
, pp. 991-1011
-
-
Núñez Miguel, R.1
Sanders, J.2
Jeffreys, J.3
Depraetere, H.4
Evans, M.5
Richards, T.6
Blundell, T.L.7
Rees Smith, B.8
Furmaniak, J.9
-
37
-
-
24644445085
-
Models of glycoprotein hormone receptor interaction
-
Moyle WR, Lin W, Myers RV, Cao D, Kerrigan JE, Bernard MP 2005 Models of glycoprotein hormone receptor interaction. Endocrine 26:189-205
-
(2005)
Endocrine
, vol.26
, pp. 189-205
-
-
Moyle, W.R.1
Lin, W.2
Myers, R.V.3
Cao, D.4
Kerrigan, J.E.5
Bernard, M.P.6
-
38
-
-
65249116958
-
Thyrotropin and homologous glycoprotein hormone receptors: Structural and functional aspects of extracellular signaling mechanisms
-
Kleinau G, Krause G 2009 Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev 30:133-151
-
(2009)
Endocr Rev
, vol.30
, pp. 133-151
-
-
Kleinau, G.1
Krause, G.2
-
39
-
-
33751242029
-
Follitropin receptors contain cryptic ligand binding sites
-
Lin W, Bernard MP, Cao D, Myers RV, Kerrigan JE, Moyle WR 2007 Follitropin receptors contain cryptic ligand binding sites. Mol Cell Endocrinol 260-262:83-92
-
(2007)
Mol Cell Endocrinol
, vol.260-262
, pp. 83-92
-
-
Lin, W.1
Bernard, M.P.2
Cao, D.3
Myers, R.V.4
Kerrigan, J.E.5
Moyle, W.R.6
-
40
-
-
23644456322
-
Thyrotropin receptor-associated diseases: From adenomata to Graves disease
-
Davies TF, Ando T, Lin RY, Tomer Y, Latif R 2005 Thyrotropin receptor-associated diseases: from adenomata to Graves disease. J Clin Invest 115:1972-1983
-
(2005)
J Clin Invest
, vol.115
, pp. 1972-1983
-
-
Davies, T.F.1
Ando, T.2
Lin, R.Y.3
Tomer, Y.4
Latif, R.5
-
41
-
-
34249789301
-
Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity
-
Chen CR, McLachlan SM, Rapoport B 2007 Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity. Endocrinology 148:2375-2382
-
(2007)
Endocrinology
, vol.148
, pp. 2375-2382
-
-
Chen, C.R.1
McLachlan, S.M.2
Rapoport, B.3
-
42
-
-
46349106497
-
Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties
-
Chen CR, McLachlan SM, Rapoport B 2008 Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology 149:3427-3434
-
(2008)
Endocrinology
, vol.149
, pp. 3427-3434
-
-
Chen, C.R.1
McLachlan, S.M.2
Rapoport, B.3
-
43
-
-
67649670443
-
A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist ant TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain
-
Chen CR, McLachlan SM, Rapoport B 2009 A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist ant TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain. Endocrinology 150:3401-3408
-
(2009)
Endocrinology
, vol.150
, pp. 3401-3408
-
-
Chen, C.R.1
McLachlan, S.M.2
Rapoport, B.3
-
44
-
-
0025743387
-
Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding
-
Nagayama Y, Russo D, Wadsworth HL, Chazenbalk GD, Rapoport B 1991 Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J Biol Chem 266:14926-14930
-
(1991)
J Biol Chem
, vol.266
, pp. 14926-14930
-
-
Nagayama, Y.1
Russo, D.2
Wadsworth, H.L.3
Chazenbalk, G.D.4
Rapoport, B.5
-
45
-
-
0034457935
-
The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: Implications for hormone-receptor interaction and antagonist design
-
Zhang M, Tong KP, Fremont V, Chen J, Narayan P, Puett D, Weintraub BD, Szkudlinski MW 2000 The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 141:3514-3517
-
(2000)
Endocrinology
, vol.141
, pp. 3514-3517
-
-
Zhang, M.1
Tong, K.P.2
Fremont, V.3
Chen, J.4
Narayan, P.5
Puett, D.6
Weintraub, B.D.7
Szkudlinski, M.W.8
|