Engineering the human thyrotropin receptor ectodomain from a non- secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera

Journal of Biological Chemistry

Volumn 272, Issue 30, 1997, Pages 18959-18965

  Chazenbalk, Gregorio D ^a   Jaume, Juan Carlos ^a   McLachlan, Sandra M ^a   Rapoport, Basil ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CARBOHYDRATE; GLYCOPROTEIN; THYROTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; GENETIC ENGINEERING; GRAVES DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION;

ADSORPTION; ANIMALS; AUTOANTIBODIES; CHO CELLS; CRICETINAE; CULTURE MEDIA; GLYCOPROTEINS; GRAVES DISEASE; HUMANS; LECTINS; MODELS, MOLECULAR; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS; PROTEIN ENGINEERING; RECEPTORS, THYROTROPIN;

ANIMALIA; MAMMALIA;

EID: 0030752377     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.30.18959     Document Type: Article

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