Development of new and selective Trypanosoma cruzi trans-sialidase inhibitors from sulfonamide chalcones and their derivatives

ChemBioChem

Volumn 10, Issue 15, 2009, Pages 2475-2479

  Kim, Jin Hyo ^a,c   Ryu, Hyung Won ^b   Shim, Jae Hoon ^a   Park, Ki Hun ^b   Withers, Stephen G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Gyeongsang National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Chagas disease; Chalcones; Enzymes; Inhibitors; Quinolinones; Trans sialidase

Indexed keywords

2' N (4 TOLUENESULFONYL)AMINOACETOPHENONE; 2,3 DIHYDRO 2 (3',4' HYDROXYPHENYL) 3 (3'',4'' HYDROXYBENZYLIDENE) 1 (4 TOLUENESULFONYL) 4(1H) QUINOLINONE; 2,3 DIHYDRO 2 (4' HYDROXYPHENYL) 3 (4'' HYDROXYBENZYLIDENE) 1 (4 TOLUENESULFONYL) 4(1H) QUINOLINONE; 3' N (4 TOLUENESULFONYL)AMINOACETOPHENONE; 4' N (4 TOLUENESULFONYL)AMINOACETOPHENONE; CATECHOL DERIVATIVE; CHALCONE DERIVATIVE; LACTOSE; QUINOLINE DERIVATIVE; SIALIDASE; SIALIDASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLYCOSYLATION; HYDROLYSIS; IC 50; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRYPANOSOMA CRUZI; X RAY CRYSTALLOGRAPHY;

CHALCONES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GLYCOPROTEINS; HUMANS; KINETICS; NEURAMINIDASE; SUBSTRATE SPECIFICITY; SULFONAMIDES; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 70350557049     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900108     Document Type: Article

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