Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo

Glycobiology

Volumn 14, Issue 7, 2004, Pages 659-670

  Agustí, Rosalía ^a   París, Gastón ^b   Ratier, Laura ^b   Frasch, Alberto C C ^b   de Lederkremer, Rosa M ^a  

^a DEPARTAMENTO DE QUÍMICA ORGÁNICA   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

Author keywords

Alternative substrates; HPAEC; Inhibitors; Trans sialidase; Trypanosoma cruzi

Indexed keywords

3 O BETA DEXTRO GALACTOPYRANOSYLARABINITOL; 3 O BETA DEXTRO GALACTOPYRANOSYLARABINOFURANONE; 3 O BETA DEXTRO GALACTOPYRANOSYLARABINOPYRANOSE; 5 (3' O BETA DEXTRO GALACTOPYRANOSYLGLUCOPENTITOL 1' YL)TETRAZOLE; AMINOSUGAR; CARBOHYDRATE DERIVATIVE; ENZYME INHIBITOR; LACTITOL; LACTOBIONIC ACID; LACTOSE; LACTOSE DERIVATIVE; N ACETYLLACTOSAMINE; SIALIDASE; UNCLASSIFIED DRUG;

ALKALINITY; AMPEROMETRY; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BINDING SITE; CARBOHYDRATE ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PARASITE VIRULENCE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; VERO CELL;

ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; ENZYME INHIBITORS; GLYCOPROTEINS; NEURAMINIDASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIALIC ACIDS; SUBSTRATE SPECIFICITY; SUGAR ALCOHOLS; TRYPANOSOMA CRUZI; VERO CELLS; VIRULENCE;

MAMMALIA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 3142733631     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/cwh079     Document Type: Article

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