Nitric oxide donor trans-[RuCl([15]aneN 4)NO] 2+ as a possible therapeutic approach for Chagas' disease

British Journal of Pharmacology

Volumn 160, Issue 2, 2010, Pages 270-282

  Guedes, Paulo Mm ^a   Oliveira, Fabiana S ^b   Gutierrez, Fredy Rs ^a   Da Silva, Grace Kelly ^a   Rodrigues, Gerson Jhonatan ^a   Bendhack, Lusiane Maria ^a   Franco, Douglas W ^a   Do Valle Matta, Maria A ^c   Zamboni, Dario S ^a   Da Silva, Roberto Santana ^b   Silva, João Santana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Department of Chemistry   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Benznidazole; Chagas' disease; NO donors; Trans RuCl( 15 aneN 4)NO 2+; Trypanosoma cruzi

Indexed keywords

BENZNIDAZOLE; NITRIC OXIDE DONOR; RUTHENIUM COMPLEX;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMASTIGOTE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; DRUG SYNERGISM; FEMALE; HUMANS; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROIMIDAZOLES; ORGANOMETALLIC COMPOUNDS; PARASITEMIA; SURVIVAL RATE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 77951683558     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00576.x     Document Type: Article

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