Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs

Molecular and Cellular Biochemistry

Volumn 337, Issue 1-2, 2010, Pages 133-143

  Nannelli, Annalisa ^a   Rossignolo, Francesco ^b   Tolando, Roberto ^b   Rossato, Paolo ^b   Pellegatti, Mario ^b   Longo, Vincenzo ^c   Giovanni Gervasi, P ^a  

^a CNR   (Italy)

^b GSK   (Italy)

^c Institute of Agricultural Biology and Biotechnology   (Italy)

Author keywords

Brain CYPs and transporters; Pig CYPs; Pig transporters; Rifampicin induction

Indexed keywords

7 BENZYLOXYQUINOLINE O DEBENZYLASE; ANTHRALDEHYDE OXIDASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2B22; CYTOCHROME P450 3A; CYTOCHROME P450 3A22; CYTOCHROME P450 3A29; CYTOCHROME P450 3A46; LUNG RESISTANCE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; OXIDOREDUCTASE; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CAPILLARY; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; ENZYME ANALYSIS; HIPPOCAMPUS; IN VIVO STUDY; LIVER PARENCHYMA; MALE; MENINX; MESENCEPHALON; MICROSOME; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; SWINE;

ANIMALS; ANTIBIOTICS, ANTITUBERCULAR; BRAIN; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; RIFAMPIN; STEROID HYDROXYLASES; SWINE; TISSUE DISTRIBUTION;

ANIMALIA; SUIDAE;

EID: 77949659019     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0292-1     Document Type: Article

References (60)

1. Guengerich FP (2005) Human cytochrome P450 enzymes. In: Ortiz de Montellano R (ed) Cytochrome P450, structure, mechanism and biochemistry, 3rd edn. Kluwer Academic, New York, pp 377-463
2. V Ravindranath MR Boyd 1995 Xenobiotic metabolism in brain Drug Metab Rev 27 419 448 10.3109/03602539508998330 1:CAS:528:DyaK2MXotlynt7Y%3D 8521749
3. E Hedlund JA Gustafsson M Warner 2001 Cytochrome P450 in the rat brain: a review Curr Drug Metab 2 245 263 10.2174/1389200013338513 1:CAS:528: DC%2BD3MXlvFeqtrs%3D 11513329 (Pubitemid 32785272)
4. HW Strobel CM Thompson L Antonovic 2001 Cytochrome P450 in brain: function and significance Curr Drug Metab 2 199 214 10.2174/1389200013338577 1:CAS:528:DC%2BD3MXktlOgsLg%3D 11469726 (Pubitemid 32544554)
5. RP Meyer M Gehlhaus R Knoth B Volk 2007 Expression and function of cytochrome P450 in brain metabolism Curr Drug Metab 8 297 306 10.2174/138920007780655478 1:CAS:528:DC%2BD2sXmsFehu74%3D 17504219 (Pubitemid 46780059)
6. SL Miksys RF Tyndale 2002 Drug-metabolizing cytochrome P450s in the brain J Psychiatry Neurosci 27 406 415 12491573
7. C Voodland TT Huang E Gryz R Bendayan JP Fawcett 2008 Expression activity and regulation of CYP3A in human and rodent brain Drug Metab Rev 40 149 168 10.1080/03602530701836712
8. CE Hagemeyer H Rosenbrock M Ditter R Koth B Volk 2003 Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain Neuroscience 117 521 529 10.1016/S0306-4522(02)00955-7 1:CAS:528:DC%2BD3sXhs1Kiu78%3D 12617959 (Pubitemid 36263148)
9. H Rosenbrock CE Hagemeyer I Singec R Knoth B Volk 1999 Testosterone metabolism in brain rat is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms J Neuroendocrinol 11 597 604 10.1046/j.1365-2826.1999. 00371.x 1:CAS:528:DyaK1MXltFCgtL0%3D 10447797 (Pubitemid 29338675)
10. H Wang HW Strobel 1997 Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P4503A9 expressed in Escherichia coli Arch Biochem Biophys 344 365 372 10.1006/abbi.1997.0230 1:CAS:528: DyaK2sXlsVGqsbg%3D 9264551 (Pubitemid 27344074)
11. B Schilter CJ Omiecinski 1993 Regional distribution and expression modulation of cytochrome P450 and epoxide hydrolase mRNA in the rat brain Mol Pharmacol 44 990 996 1:CAS:528:DyaK2cXltVOmsg%3D%3D 8246922
12. SC Upadhya SJ Chinta HV Pai MR Boyd V Ravindranath 2002 Toxicological consequences of differential regulation of cytochrome P450 isoforms in rat brain regions by phenobarbital Arch Biochem Biophys 399 56 65 10.1006/abbi.2001.2727 1:CAS:528:DC%2BD38Xhs1yktr0%3D 11883903
13. S Yadav A Dhawan PK Seth RL Singh D Parmar 2006 Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain Mol Cell Biochem 287 91 99 10.1007/s11010-005-9080-8 1:CAS:528:DC%2BD28XmvVaqs7k%3D 16673044 (Pubitemid 44057396)
14. S Marini A Nannelli D Sodini S Dragoni M Valoti V Longo PG Gervasi 2007 Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits Life Sci 80 910 917 10.1016/j.lfs.2006.11.022 1:CAS:528:DC%2BD2sXhtlehtrk%3D 17161434 (Pubitemid 46186419)
15. MC McFadyen WT Melvin GI Murray 1998 Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain Biochem Pharmacol 55 825 830 10.1016/S0006-2952(97)00516-9 1:CAS:528:DyaK1cXitVKgsr8%3D (Pubitemid 28319646)
16. V Lamba K Yasuda JK Lamba M Assem J Davila S Strom EG Schuetz 2004 PXR (NR112): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators Toxicol Appl Pharmacol 199 251 265 10.1016/j.taap.2003.12.027 1:CAS:528:DC%2BD2cXnsFGgurw%3D 15364541 (Pubitemid 39208725)
17. SA Kliewer B Goodwin TM Willson 2002 The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism Endocr Rev 23 687 702 10.1210/er.2001-0038 1:CAS:528:DC%2BD38XosVejtr4%3D 12372848 (Pubitemid 35191629)
18. GG Gibson NJ Plant KE Swales A Ayrton W El-Sankary 2002 Receptor-dependent transcription activation of cytochrome P4503A genes: induction mechanism, species differences and interindividual variation in man Xenobiotica 32 165 206 10.1080/00498250110102674 1:CAS:528:DC%2BD38XivFGhtL0%3D 11958559 (Pubitemid 34267348)
19. B Goodwin LB Moore CM Stoltz DD McKee SA Kliewer 2001 Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor Mol Pharmacol 60 427 431 1:CAS:528:DC%2BD3MXmtFantbs%3D 11502872
20. TW Synold L Dussault BM Forman 2001 The orphan nuclear receptor SXR co-ordinately regulates drug metabolism and efflux Nat Med 7 584 590 10.1038/87912 1:CAS:528:DC%2BD3MXjsVaku74%3D 11329060 (Pubitemid 32448326)
21. A Geick M Eichelbaum O Burk 2001 Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin J Biol Chem 276 14587 14591 10.1074/jbc.M010173200
22. W Xie MF Yeuh A Radominska-Pandya SP Saini Y Negishi BS Bottruff GY Cabrera RH Tukey RM Evans 2003 Control of steroid, heme and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor Proc Natl Acad Sci USA 100 4150 4155 10.1073/pnas.0438010100 1:CAS:528:DC%2BD3sXivFWjsrs%3D 12644700 (Pubitemid 36418172)
23. DR Johnson CD Klaassen 2002 Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways Toxicol Sci 67 182 189 10.1093/toxsci/67.2.182 1:CAS:528:DC%2BD38Xkt1Sltbc%3D 12011477 (Pubitemid 34746471)
24. JM Maher AL Slitt NJ Cherrington X Cheng CD Klaassen 2005 Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (MRP) family in mice Drug Metab Dispos 33 947 955 10.1124/dmd.105.003780 1:CAS:528:DC%2BD2MXlslWqs7Y%3D 15802388 (Pubitemid 41002776)
25. M Nishimura S Naito T Yokoy 2004 Tissue-specific mRNA expression profiles of human nuclear receptor subfamily Drug Metab Pharmacokinet 19 135 149 10.2133/dmpk.19.135 1:CAS:528:DC%2BD2cXlsFKjs7Y%3D 15499180
26. S Dallas DS Miller R Bendayan 2006 Multidrug resistance-associated proteins: expression and function in the central nervous system Pharmacol Rev 58 140 161 10.1124/pr.58.2.3 1:CAS:528:DC%2BD28XlvVelsL0%3D 16714484 (Pubitemid 43752631)
27. CL Aquilante SP Letrent GM Pollack KLR Brower 2000 Increased brain p-glycoprotein in morphine tolerant rats Life Sci 66 47 51
28. CJ Matheny RY Ali X Yang GM Pollack 2004 Effect of prototypical inducing agents on p-glycoprotein and CYP3A expression in mouse tissues Drug Metab Dispos 32 1008 1014 1:CAS:528:DC%2BD2cXnsVegtb0%3D 15319343
29. B Bauer AMS Hartz G Fricker DS Miller 2004 Pregnane X receptor up-regulation of p-glycoprotein expression and transport function at the blood-brain barrier Mol Pharmacol 66 413 419 1:CAS:528:DC%2BD2cXntlCksrc%3D 15322232
30. Q Mei K Richards K Strong-Basalyga SE Fauty A Taylor M Yamazaki T Prueksaritanont JH Lin J Hochman 2004 Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat p-glycoproteins mdr1a/1b and cytochrome P4503A1/2 J Pharm Sci 93 2488 2496 10.1002/jps.20102 1:CAS:528:DC%2BD2cXotl2gtrY%3D 15349958 (Pubitemid 39319432)
31. MM Swindle AC Smith 1998 Comparative anatomy and physiology of the pig Scand J Lab Anim Sci 25 Suppl 1 11 22
32. V Longo A Mazzaccaro F Naldi PG Gervasi 1991 Drug metabolizing enzymes in liver, olfactory and respiratory epithelium of cattle J Biochem Toxicol 6 123 128 10.1002/jbt.2570060206 1:CAS:528:DyaK3MXlslCjsL8%3D 1941898
33. BB Mrsulja BJ Mrsulja T Fujimoto L Klatzo M Spetz 1976 Isolation of brain capillaries: a simplified technique Brain Res 110 361 365 10.1016/0006-8993(76) 90408-X 1:CAS:528:DyaE28XkslCmtL4%3D 938949
34. NR Sims 1990 Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation J Neurochem 55 698 707 10.1111/j.1471-4159.1990.tb04189.x 1:CAS:528: DyaK3cXltFWrt7c%3D 2164576
35. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
36. DM Stresser AP Blanchard SD Turner JCL Erve AA Dandeneau VP Miller LC Crespi 2000 Substrate-dependent modulation of CYP3A catalytic activity: analysis of 27 test compounds with four fluorimetric substrates Drug Metab Dispos 28 1440 1448 1:CAS:528:DC%2BD3cXos1Srsrk%3D 11095581
37. S Marini E Grasso V Longo P Puccini B Riccardi PG Gervasi 2003 4-Biphenylaldehyde and 9-anthraldehyde. Two fluorescent substrates for determining P450 enzyme activities in rat and human Xenobiotica 33 1 11 10.1080/0049825021000017894 1:CAS:528:DC%2BD3sXit1CnsA%3D%3D 12519690 (Pubitemid 36071759)
38. G Amato V Longo A Mazzaccaro PG Gervasi 1996 Microsomal oxidation of N,N-diethylformamide and its effect on P450-dependent monooxygenases in rat liver Chem Res Toxicol 9 882 890 10.1021/tx950201u 1:CAS:528:DyaK28Xjs1Oktbc%3D 8828925 (Pubitemid 26250583)
39. A Ghosal N Hapangama Y Yuan LV Favreau JR Palamanda JE Partick MN Cayen S Zbaida 2000 Microtiter plate-based assay for rapid determination of enzyme activities of 13 P-450 supersomes and human liver microsomes Drug Metab Rev 32 Suppl 2 188 197
40. A Nannelli V Chirulli V Longo PG Giovanni 2008 Expression and induction by rifampicin of CAR- and PXR- regulated CYP2B and CYP3As in liver kidney and airways of pig Toxicology 252 105 112 10.1016/j.tox.2008.08.004 1:CAS:528:DC%2BD1cXht1ens7bI 18786598
41. A Messina V Chirulli PG Gervasi V Longo 2008 Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2 Xenobiotica 38 1453 1470 10.1080/00498250802474437 1:CAS:528:DC%2BD1cXhsVWmur%2FJ 18949657
42. M Liu PD Hurn NJ Alkayed 2004 Cytochrome P450 in neurological disease Curr Drug Metab 5 225 234 10.2174/1389200043335540 1:CAS:528: DC%2BD2cXktlKksrY%3D 15180492 (Pubitemid 38735777)
43. M Nishimura H Yaguti H Yoshitsugu S Naito T Satoh 2003 Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR Yakugaku Zasshi 123 369 375 10.1248/yakushi.123.369 1:CAS:528:DC%2BD3sXktF2qurc%3D 12772594
44. RP Meyer CE Hagemeyer R Knoth MR Kaufmann B Volk 2006 Anti-epilectic drug phenytoin enhances androgen metabolism and androgen receptor expression in murine hippocampus J Neurochem 96 460 472 10.1111/j.1471-4159.2005.03555.x 1:CAS:528:DC%2BD28XntVSitw%3D%3D 16336225
45. J Fleming 2001 Cytochrome P450 enzymes in vascular homeostasis Circ Res 89 753 762 10.1161/hh2101.099268 1:CAS:528:DC%2BD3MXot1ynu78%3D 11679404
46. B Schilter MR Andersen C Acharya CJ Omiecinski 2000 Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers J Pharmacol Exp Ther 294 916 922 1:CAS:528:DC%2BD3cXmtFCntr8%3D 10945841
47. T Mindermann W Zimmerli O Gratzl 1998 Rifampin concentrations in various compartments of the human brain: a novel method for determining drug levels in the cerebral extracellular space Antimicrob Agents Chemother 42 2626 2629 1:CAS:528:DyaK1cXms1Gjsro%3D 9756766
48. JK Lamba V Lamba K Yasuda YS Lin M Assem E Thompson S Strom EG Schuetz 2004 Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences J Pharmacol Exp Ther 311 811 821 10.1124/jpet.104.069310 1:CAS:528:DC%2BD2cXptVKqsr8%3D 15194709 (Pubitemid 39391571)
49. RG Tirona W Lee BF Leake LB Lan CB Cline V Lamba F Parviz SA Ducan Y Inoue FJ Gonzalez E Schuetz RB Kim 2003 The orphan nuclear receptor HNF4α determines PXR-and CAR-mediated xenobiotic induction of CYP3A4 Nat Med 9 220 224 10.1038/nm815 1:CAS:528:DC%2BD3sXotlShtA%3D%3D 12514743 (Pubitemid 36227725)
50. M Nishimura A Koeda E Suzuki Y Kawano M Nakayama T Satoh S Narimatsu S Naito 2006 Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsome enzyme inducers in primary cultures of human and rat hepatocytes Drug Metab Pharmacokinect 21 297 307 10.2133/dmpk.21.297 1:CAS:528:DC%2BD28XhtVOmtb%2FM
51. G Jedlitschky I Leier U Buchholz J Hummel-Eisenheiss B Burchell D Keppler 1997 ATP-dependent transport of bilirubin glucuronides by the multidrug resistant protein MRP1 and its hepatocyte canalicular isoform MRP2 Biochem J 327 Pt 1 305 310 1:CAS:528:DyaK2sXmvVGru7g%3D 9355767
52. HR Kast B Goodwin PT Tarr SA Jones AM Anisfeld CM Stolz P Tontonoz S Kliewer TM Willson PA Edwards 2002 Regulation of multidrug regulated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor and constitutive androstane receptor J Biol Chem 277 2908 2915 10.1074/jbc.M109326200 1:CAS:528:DC%2BD38XhtVSgt7c%3D 11706036
53. L Salphati LZ Benet 1998 Modulation of p-glycoprotein expression by cytochrome P4503A inducers in male and female rat livers Biochem Pharmacol 55 387 395 10.1016/S0006-2952(97)00436-X 1:CAS:528:DyaK1cXmsVyrtQ%3D%3D 9514072 (Pubitemid 28070142)
54. VJ Wacher CY Wu LZ Benet 1995 Overlapping substrate specificity and tissue distribution of cytochrome P4503A and p-glycoprotein: implications from drug delivery and activity in cancer chemotherapy Mol Carcinog 13 129 134 10.1002/mc.2940130302 1:CAS:528:DyaK2MXnt1ams7k%3D 7619215
55. RB Kim C Wandel B Laeke M Cvetkovic MF Fromm PJ Demsey MM Roden F Belas AK Chaudhary DM Roden AJJ Wood GR Wilkinson 1999 Interrelationship between substrates and inhibitors of human CYP3A and p-glycoprotein Pharmacol Res 16 408 414 10.1023/A:1018877803319 1:CAS:528:DyaK1MXisFWntLo%3D
56. EM Leslie RG Deeley SPC Cole 2005 Multidrug resistance proteins: role of p-glycoprotein, MRP1, MRP2 and BCRP (ABCG2) in tissue defence Toxicol Appl Pharmacol 204 216 237 10.1016/j.taap.2004.10.012 1:CAS:528:DC%2BD2MXjsFGqtrY%3D 15845415 (Pubitemid 40552845)
57. Y Zhang CSW Li Y Ye K Johnson J Poe S Johnson W Bobrowski R Garrido C Madhu 2006 Porcine brain microvessel endothelial cells as an in vitro model to predict in vivo blood-brain barrier permeability Drug Metab Dispos 34 1935 1943 10.1124/dmd.105.006437 1:CAS:528:DC%2BD28XhtFGqt7nE 16896068
58. B Bauer AMS Hartz JR Lucking X Yang GM Pollack DS Miller 2008 Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolising enzyme, GSTπ, at the blood-brain barrier J Cereb Blood Flow Metab 28 1222 1234 10.1038/jcbfm.2008.16 1:CAS:528:DC%2BD1cXmt1SgsLY%3D 18349876
59. S Labialle L Gayet R Marthinet D Rigal LG Baggetto 2002 Transcriptional regulators of the human multidrug resistance 1 gene: recent views Biochem Pharmacol 64 943 948 10.1016/S0006-2952(02)01156-5 1:CAS:528: DC%2BD38Xms1yms7c%3D 12213590 (Pubitemid 35232268)
60. W Seul HS Choi DD Moore 1996 An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors Science 272 1336 1339 10.1126/science.272.5266.1336