Basic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. I. The PI3K/AKT pathway and induction of phosphorylation of BAD

Radiation Research

Volumn 161, Issue 6, 2004, Pages 692-702

  Gu, Qingyang ^a   Wang, Dewen ^a   Wang, Xiaodan ^a,b   Peng, Ruiyun ^a   Liu, Jie ^a   Jiang, Tao ^a   Wang, Zhaohai ^a,c   Wang, Shuiming ^a   Deng, Hua ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c Beijing 307 Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; CASPASE 9; COBALT 60; FIBROBLAST GROWTH FACTOR RECEPTOR 1; I KAPPA B KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN BAD; PROTEIN KINASE B; VASCULOTROPIN; WORTMANNIN; AKT1 PROTEIN, HUMAN; BAD PROTEIN, HUMAN; CARRIER PROTEIN; FIBROBLAST GROWTH FACTOR 2; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL SURVIVAL; ENDOTHELIUM CELL; ENZYME ACTIVATION; GAMMA IRRADIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RADIATION EXPOSURE; RADIATION INJURY; RECEPTOR AFFINITY; SKIN ULCER; ULCER HEALING; UMBILICAL VEIN; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GAMMA RADIATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RADIATION DOSE; RADIATION RESPONSE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; GAMMA RAYS; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; UMBILICAL VEINS;

EID: 3042679663     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3158     Document Type: Article

References (49)

1. H. S. Chang, D. B. Hom and R. P. Agarwal, Effects of basic fibroblast growth factor on irradiated porcine skin flaps. Arch. Otolaryngol. Head Neck Surg. 124, 307-312 (1998).
2. F. Paris, Z. Fuks, A. Kang, P. Capodieci, G. Juan, D. Ehleiter, A. Haimovitz-Friedman, C. Cordon-Cardo and R. Kolesnick, Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293, 293-297 (2001).
3. Z. Fuks, A. Alfieri, A. Haimovitz-Friedman, A. Seddon and C. Cordon-Cardo, Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo. Cancer J. Sci. Am. 1, 62-72 (1995).
4. A. Baird and M. A. Klagsburn, The fibroblast growth factor family. An overview. Ann. NY Acad. Sci. 638, 11-16 (1991).
5. D. Gospodarowicz, N. Ferrara, L. Schweigerer and G. Neufeld, Structural characterization and biological functions of fibroblast growth factor. Endocr. Rev. 8, 95-114 (1987).
6. C. Basilico and D. Moscatelli, The bFGF family of growth factors and oncogenes. Adv. Cancer Res. 59, 115-165 (1992).
7. C. S. Nicoll, L. Liu, E. Alaird and S. M. Russell, The role of basic fibroblast growth factor in prenatal development in the rat. Ann. NY Acad. Sci. 68, 283-289 (1991).
8. J. Folkman and Y. Hing, Angiogenesis. J. Biol. Chem. 267, 10931-10934 (1992).
9. J. M. Davidson and K. N. Broadley, Manipulation of the wound healing process with basic fibroblast growth factor. Ann. NY Acad. Sci. 68, 306-315 (1991).
10. R. E. Langley, E. A. Bump, S. G. Quartuccio, D. Medeiros and S. J. Braunhut, Radiation-induced apoptosis in microvascular endotheliocytes. Br. J. Cancer 75, 666-672 (1997).
11. L. A. Pena, Z. Fuks and R. N. Kolesnick, Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res. 60, 321-327 (2000).
12. E. S. Kandel and N. Hay, The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229 (1999).
13. H. P. Gerber, A. McMurtrey and J. Kowalski, Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway. J. Biol. Chem. 273, 30336-30343 (1998).
14. Y. Fujio and K. Walsh, Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J. Biol. Chem. 274, 16349-16354 (1999).
15. B. H. Jiang, J. Z. Zheng and M. Aoki, Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA. 97, 1749-1753 (2000).
16. B. Vanhaesebroeck and D. R. Alessi, The PI3K-PDK1 connection: More than just a road to PKB. Biochem. J. 346, 561-576 (2000).
17. A. Nakashio, N. Fujita and S. Rokudai, Prevention of phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis. Cancer Res. 60, 5303-5309 (2000).
18. A. Nakashio, N. Fujita and T. Tsuruo, Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway. Int. J. Cancer 98, 36-41 (2002).
19. S. Wennstrom, A. Siegbahn, K. Yokote, A. K. Arvidsson, C. H. Heldin, S. Mori and L. Claesson-Welsh, Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene 9, 651-660 (1994).
20. H. P. Gerber, A. McMurtrey, J. Kowalski, M. Yan, B. A. Keyt, V. Dixit and N. Ferrara, Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: requirement for Flk-1/KDR activation. J. Biol. Chem. 273, 30336-30343 (1998).
21. R. Okayasu, K. Suetomi and R. Ullrich, Wortmannin inhibits repair of DNA double-strand breaks. Radiat. Res. 149, 440-445 (1998).
22. S. Chernikova, R. Wells and M. Elkind, Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat. Res. 151, 159-166 (1999).
23. K. Savitsky, A. Bar-Shira, S. Gilod, G. Rotman, Y. Ziv, L. Vanagaite, D. A. Tagle, S. Smith, T. Uziel and S. Sfez, A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753 (1995).
24. J. Sarkaria, R. Tibbetts, E. Busby, A. Kennedy, D. Hill and R. Abraham, Inhibition of phosphoinositide 3-kinase related kinases ty the radiosensitizing agent wortmannin. Cancer Res. 58, 4375-4382 (1998).
25. K. Hartley, D. Gell, G. Smith, H. Zhang, N. Divecha, M. A. Connelly, A. Admon, S. P. Lees-Miller, C. W. Anderson and S. P. Jackson, DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856 (1995).
26. R. Izzard, S. Jackson and G. Smith, Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res. 59, 2581-2586 (1999).
27. L. Cell 87, 619-628 (1996).
28. S. R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M. E. Greenberg, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
29. L. del Peso, M. Gonzalez-Garcia, C. Page, R. Herrera and G. Nunez, Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689 (1997).
30. A. Bonni, A. Brunet, A. E. West, S. R. Datta, M. A. Takasu and M. E. Greenberg, Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358-1362 (1999).
31. T. J. McMillan, Residual DNA damage: What is left over and how does this determine cell fate. Eur. J. Cancer 28, 267-269 (1992).
32. 1/S checkpoint activation in response to DNA damage. Proc. Natl. Acad. Sci. USA 98, 13102-13107 (2001).
33. R. Maya, M. Balass, S. Kim, D. Shkedy, J. Leal, O. Shifman, M. Moas, T. Buschmann, Z. Ronai and M. Oren, ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage. Genes Dev. 15, 1067-1077 (2001).
34. N. Li, S. Banin, H. Ouyang, G. Li, G. Courtois, Y. Shiloh, M. Karin and G. Rotman, ATM is required for IκB kinase (IKKk) activation in response to DNA double strand breaks. J. Biol. Chem. 276, 8898-8903 (2001).
35. S. Bao, R. Tibbetts, K. Brumbaugh, Y. Fang, D. Richardson, A. Ali, S. Chen, R. Abraham and X. Wang, ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411, 969-974 (2001).
36. J. Chen, Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 60, 5037-5039 (2000).
37. 2-terminal kinase through MKK7 in human thyroid cells. Oncogene 20, 989-996 (2001).
38. K. Suzuki, S. Kodama and M. Watanabe, Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Res. 61, 5396-5401 (2001).
39. E. Edwards, L. Geng, J. Tan, H. Onishko, E. Donnelly and D. E. Hallahan, Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 62, 4671-4677 (2002).
40. L. A. Pena, Z. Fuks and R. N. Kolesnick, Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res. 60, 321-327 (2000).
41. Z. Fuks, R. S. Persaud, A. Alfieri, M. McLoughlin, D. Ehleiter, J. L. Schwartz, A. P. Seddon, C. Cordon-Cardo and A. Haimovitz-Friedman, Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res. 54, 2582-2590 (1994).
42. W. Fantl, D. Jonson and L. Williams, Signaling by receptor tyrosine kinases. Annu. Rev. Biochem. 62, 453-481 (1993).
43. S. Datta, A. Brunet and M. Greenberg, Cellular survival: A play in three Akts. Genes Dev. 13, 2905-2927 (1999).
44. M. Wymann and L. Pirola, Structure and function of phosphoinositide 3-kinases. Biochem. Biophys. Acta 1436, 127-150 (1998).
45. E. Tang, G. Nunez, F. Barr and K. Guan, Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274, 16741-16746 (1999).
46. S. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M. Greenberg, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
47. M. Cardone, N. Roy, H. R. Stennicke, G. S. Salvesen, T. F. Franke, E. Stanbridge, S. Frisch and J. C. Reed, Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321 (1998).
48. S. Kennedy, E. Kandel, T. Cross and N. Hay, Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell Biol. 19, 5800-5810 (1999).
49. J. Brognard, A. Clark, Y. Ni and P. Dennis, Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res. 61, 3986-3997 (2001).