메뉴 건너뛰기




Volumn 29, Issue 11, 2010, Pages 1672-1680

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

Author keywords

Crtc1; LKB1; Lung cancer; Mect1 Torc1; NR4A2

Indexed keywords

NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN CRTC2; PROTEIN KINASE LKB1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 77949654290     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.453     Document Type: Article
Times cited : (41)

References (48)
  • 1
    • 67349263518 scopus 로고    scopus 로고
    • Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma
    • Achcar RD, Nikiforova MN, Dacic S, Nicholson AG, Yousem SA. (2009). Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol 40: 854-860.
    • (2009) Hum Pathol , vol.40 , pp. 854-860
    • Achcar, R.D.1    Nikiforova, M.N.2    Dacic, S.3    Nicholson, A.G.4    Yousem, S.A.5
  • 3
    • 10344262616 scopus 로고    scopus 로고
    • Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins
    • Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, et al. (2004). Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr Biol 14: 2156-2161.
    • (2004) Curr Biol , vol.14 , pp. 2156-2161
    • Bittinger, M.A.1    McWhinnie, E.2    Meltzer, J.3    Iourgenko, V.4    Latario, B.5    Liu, X.6
  • 4
    • 67349096949 scopus 로고    scopus 로고
    • Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: A case report with molecular analysis and review of the literature
    • Camelo-Piragua SI, Habib C, Kanumuri P, Lago CE, Mason HS, Otis CN. (2009). Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature. Hum Pathol 40: 887-892.
    • (2009) Hum Pathol , vol.40 , pp. 887-892
    • Camelo-Piragua, S.I.1    Habib, C.2    Kanumuri, P.3    Lago, C.E.4    Mason, H.S.5    Otis, C.N.6
  • 5
    • 33646020680 scopus 로고    scopus 로고
    • LKB1: A sweet side to Peutz-Jeghers syndrome?
    • Carling D. (2006). LKB1: a sweet side to Peutz-Jeghers syndrome? Trends Mol Med 12: 144-147.
    • (2006) Trends Mol Med , vol.12 , pp. 144-147
    • Carling, D.1
  • 8
    • 23844523415 scopus 로고    scopus 로고
    • Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes
    • Coxon A, Rozenblum E, Park YS, Joshi N, Tsurutani J, Dennis PA, et al. (2005). Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res 65: 7137-7144.
    • (2005) Cancer Res , vol.65 , pp. 7137-7144
    • Coxon, A.1    Rozenblum, E.2    Park, Y.S.3    Joshi, N.4    Tsurutani, J.5    Dennis, P.A.6
  • 9
    • 34548831102 scopus 로고    scopus 로고
    • Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
    • Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, et al. (2007). Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449: 366-369.
    • (2007) Nature , vol.449 , pp. 366-369
    • Dentin, R.1    Liu, Y.2    Koo, S.H.3    Hedrick, S.4    Vargas, T.5    Heredia, J.6
  • 10
    • 0346725846 scopus 로고    scopus 로고
    • Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors
    • Enlund F, Behboudi A, Andren Y, Oberg C, Lendahl U, Mark J, et al. (2004). Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res 292: 21-28.
    • (2004) Exp Cell Res , vol.292 , pp. 21-28
    • Enlund, F.1    Behboudi, A.2    Andren, Y.3    Oberg, C.4    Lendahl, U.5    Mark, J.6
  • 11
    • 58049217333 scopus 로고    scopus 로고
    • Using kinomics to delineate signaling pathways: Control of CRTC2/TORC2 by the AMPK family
    • Fu A, Screaton RA. (2008). Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family. Cell Cycle 7: 3823-3828.
    • (2008) Cell Cycle , vol.7 , pp. 3823-3828
    • Fu, A.1    Screaton, R.A.2
  • 12
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, et al. (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28.
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6
  • 13
    • 56749176442 scopus 로고    scopus 로고
    • LKB1; Linking cell structure and tumor suppression
    • Hezel AF, Bardeesy N. (2008). LKB1; linking cell structure and tumor suppression. Oncogene 27: 6908-6919.
    • (2008) Oncogene , vol.27 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 14
    • 33646348742 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer
    • Holla VR, Mann JR, Shi Q, DuBois RN. (2006). Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J Biol Chem 281: 2676-2682.
    • (2006) J Biol Chem , vol.281 , pp. 2676-2682
    • Holla, V.R.1    Mann, J.R.2    Shi, Q.3    Dubois, R.N.4
  • 15
    • 0041305909 scopus 로고    scopus 로고
    • Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
    • Hong SP, Leiper FC, Woods A, Carling D, Carlson M. (2003). Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci USA 100: 8839-8843.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8839-8843
    • Hong, S.P.1    Leiper, F.C.2    Woods, A.3    Carling, D.4    Carlson, M.5
  • 16
    • 44449103256 scopus 로고    scopus 로고
    • Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    • Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, et al. (2008). Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 412: 211-221.
    • (2008) Biochem J , vol.412 , pp. 211-221
    • Huang, X.1    Wullschleger, S.2    Shpiro, N.3    McGuire, V.A.4    Sakamoto, K.5    Woods, Y.L.6
  • 17
    • 0142091390 scopus 로고    scopus 로고
    • Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
    • Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (2003). Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci USA 100: 12147-12152.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12147-12152
    • Iourgenko, V.1    Zhang, W.2    Mickanin, C.3    Daly, I.4    Jiang, C.5    Hexham, J.M.6
  • 20
    • 33745286771 scopus 로고    scopus 로고
    • Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade
    • Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, et al. (2006). Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. FEBS J 273: 2730-2748.
    • (2006) FEBS J , vol.273 , pp. 2730-2748
    • Katoh, Y.1    Takemori, H.2    Lin, X.Z.3    Tamura, M.4    Muraoka, M.5    Satoh, T.6
  • 21
    • 33746095020 scopus 로고    scopus 로고
    • Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer
    • Kaye FJ. (2006). Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer. Clin Cancer Res 12: 3878-3881.
    • (2006) Clin Cancer Res , vol.12 , pp. 3878-3881
    • Kaye, F.J.1
  • 22
    • 67649342915 scopus 로고    scopus 로고
    • Mutation-associated fusion cancer genes in solid tumors
    • Kaye FJ. (2009). Mutation-associated fusion cancer genes in solid tumors. Mol Cancer Ther 8: 1399-1408.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1399-1408
    • Kaye, F.J.1
  • 24
    • 8544281699 scopus 로고    scopus 로고
    • Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis
    • Ke N, Claassen G, Yu DH, Albers A, Fan W, Tan P, et al. (2004). Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis. Cancer Res 64: 8208-8212.
    • (2004) Cancer Res , vol.64 , pp. 8208-8212
    • Ke, N.1    Claassen, G.2    Yu, D.H.3    Albers, A.4    Fan, W.5    Tan, P.6
  • 25
    • 33749854559 scopus 로고    scopus 로고
    • Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation
    • Komiya T, Park Y, Modi S, Coxon A, Oh H, Kaye FJ. (2006). Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. Oncogene 25: 6128-6132.
    • (2006) Oncogene , vol.25 , pp. 6128-6132
    • Komiya, T.1    Park, Y.2    Modi, S.3    Coxon, A.4    Oh, H.5    Kaye, F.J.6
  • 26
    • 34248388957 scopus 로고    scopus 로고
    • TORC1 is a calcium-and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity
    • Kovacs KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, et al. (2007). TORC1 is a calcium-and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc Natl Acad Sci USA 104: 4700-4705.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4700-4705
    • Kovacs, K.A.1    Steullet, P.2    Steinmann, M.3    Do, K.Q.4    Magistretti, P.J.5    Halfon, O.6
  • 27
    • 67549102534 scopus 로고    scopus 로고
    • Mucoepidermoid Carcinoma of the Cervix: Another Tumor with the t(11;19)-associated CRTC1-MAML2 Gene Fusion
    • Lennerz JK, Perry A, Mills JC, Huettner PC, Pfeifer JD. (2009). Mucoepidermoid Carcinoma of the Cervix: Another Tumor With the t(11;19)-associated CRTC1-MAML2 Gene Fusion. Am J Surg Pathol 33: 835-843
    • (2009) Am J Surg Pathol , vol.33 , pp. 835-843
    • Lennerz, J.K.1    Perry, A.2    Mills, J.C.3    Huettner, P.C.4    Pfeifer, J.D.5
  • 28
    • 33645566549 scopus 로고    scopus 로고
    • NR4A1, 2, 3-an orphan nuclear hormone receptor family involved in cell apoptosis and carcinogenesis
    • Li QX, Ke N, Sundaram R, Wong-Staal F. (2006). NR4A1, 2, 3-an orphan nuclear hormone receptor family involved in cell apoptosis and carcinogenesis. Histol Histopathol 21: 533-540.
    • (2006) Histol Histopathol , vol.21 , pp. 533-540
    • Li, Q.X.1    Ke, N.2    Sundaram, R.3    Wong-Staal, F.4
  • 29
    • 61449218839 scopus 로고    scopus 로고
    • TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons
    • Li S, Zhang C, Takemori H, Zhou Y, Xiong ZQ. (2009). TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J Neurosci 29: 2334-2343.
    • (2009) J Neurosci , vol.29 , pp. 2334-2343
    • Li, S.1    Zhang, C.2    Takemori, H.3    Zhou, Y.4    Xiong, Z.Q.5
  • 30
    • 70249146228 scopus 로고    scopus 로고
    • Activation of Thromboxane A2 Receptors Induces Orphan Nuclear Receptor Nurr1 Expression and Stimulates Cell Proliferation in Human Lung Cancer Cells
    • Li X, Tai HH. (2009). Activation of Thromboxane A2 Receptors Induces Orphan Nuclear Receptor Nurr1 Expression and Stimulates Cell Proliferation in Human Lung Cancer Cells. Carcinogenesis 30: 1606-1613.
    • (2009) Carcinogenesis , vol.30 , pp. 1606-1613
    • Li, X.1    Tai, H.H.2
  • 31
    • 12144287284 scopus 로고    scopus 로고
    • LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    • Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J, et al. (2004). LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23: 833-843.
    • (2004) EMBO J , vol.23 , pp. 833-843
    • Lizcano, J.M.1    Goransson, O.2    Toth, R.3    Deak, M.4    Morrice, N.A.5    Boudeau, J.6
  • 32
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
    • Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. (2002). Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 16: 948-958.
    • (2002) Genes Dev , vol.16 , pp. 948-958
    • Paddison, P.J.1    Caudy, A.A.2    Bernstein, E.3    Hannon, G.J.4    Conklin, D.S.5
  • 33
    • 33748463364 scopus 로고    scopus 로고
    • NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
    • Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. (2006). NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med 12: 1048-1055.
    • (2006) Nat Med , vol.12 , pp. 1048-1055
    • Pei, L.1    Waki, H.2    Vaitheesvaran, B.3    Wilpitz, D.C.4    Kurland, I.J.5    Tontonoz, P.6
  • 34
    • 34250814515 scopus 로고    scopus 로고
    • Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
    • Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates 3rd JR, et al. (2007). Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J 26: 2880-2889.
    • (2007) EMBO J , vol.26 , pp. 2880-2889
    • Ravnskjaer, K.1    Kester, H.2    Liu, Y.3    Zhang, X.4    Lee, D.5    Yates III, J.R.6
  • 35
    • 37149042642 scopus 로고    scopus 로고
    • A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
    • Sanchez-Cespedes M. (2007). A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome. Oncogene 26: 7825-7832.
    • (2007) Oncogene , vol.26 , pp. 7825-7832
    • Sanchez-Cespedes, M.1
  • 37
    • 5344228270 scopus 로고    scopus 로고
    • The CREB coactivator TORC2 functions as a calcium-and cAMP-sensitive coincidence detector
    • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (2004). The CREB coactivator TORC2 functions as a calcium-and cAMP-sensitive coincidence detector. Cell 119: 61-74.
    • (2004) Cell , vol.119 , pp. 61-74
    • Screaton, R.A.1    Conkright, M.D.2    Katoh, Y.3    Best, J.L.4    Canettieri, G.5    Jeffries, S.6
  • 38
    • 45549086246 scopus 로고    scopus 로고
    • LKB1 and lung cancer: More than the usual suspects
    • Shah U, Sharpless NE, Hayes DN. (2008). LKB1 and lung cancer: more than the usual suspects. Cancer Res 68: 3562-3565.
    • (2008) Cancer Res , vol.68 , pp. 3562-3565
    • Shah, U.1    Sharpless, N.E.2    Hayes, D.N.3
  • 39
    • 73949111049 scopus 로고    scopus 로고
    • Tumor suppression by LKB1: SIK-ness prevents metastasis
    • Shaw RJ. (2009). Tumor suppression by LKB1: SIK-ness prevents metastasis. Sci Signal 2: pe55.
    • (2009) Sci Signal , vol.2
    • Shaw, R.J.1
  • 41
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. (2005). The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646.
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 42
    • 0033529838 scopus 로고    scopus 로고
    • Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
    • Tiainen M, Ylikorkala A, Makela TP. (1999). Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96: 9248-9251.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9248-9251
    • Tiainen, M.1    Ylikorkala, A.2    Makela, T.P.3
  • 43
    • 34249081691 scopus 로고    scopus 로고
    • CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: Implications for histogenesis and biologic behavior
    • Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. (2007). CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer 46: 708-715.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 708-715
    • Tirado, Y.1    Williams, M.D.2    Hanna, E.Y.3    Kaye, F.J.4    Batsakis, J.G.5    El-Naggar, A.K.6
  • 44
    • 0037313331 scopus 로고    scopus 로고
    • T(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
    • Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, et al. (2003). t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 33: 208-213.
    • (2003) Nat Genet , vol.33 , pp. 208-213
    • Tonon, G.1    Modi, S.2    Wu, L.3    Kubo, A.4    Coxon, A.B.5    Komiya, T.6
  • 46
    • 42649140573 scopus 로고    scopus 로고
    • The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila
    • Wang B, Goode J, Best J, Meltzer J, Schilman PE, Chen J, et al. (2008). The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab 7: 434-444.
    • (2008) Cell Metab , vol.7 , pp. 434-444
    • Wang, B.1    Goode, J.2    Best, J.3    Meltzer, J.4    Schilman, P.E.5    Chen, J.6
  • 47
    • 22744458562 scopus 로고    scopus 로고
    • Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation
    • Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, et al. (2005). Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J 24: 2391-2402.
    • (2005) EMBO J , vol.24 , pp. 2391-2402
    • Wu, L.1    Liu, J.2    Gao, P.3    Nakamura, M.4    Cao, Y.5    Shen, H.6
  • 48
    • 55149088605 scopus 로고    scopus 로고
    • Requirement of TORC1 for late-phase long-term potentiation in the hippocampus
    • Zhou Y, Wu H, Li S, Chen Q, Cheng XW, Zheng J, et al. (2006). Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS ONE 1: e16.
    • (2006) PLoS ONE , vol.1
    • Zhou, Y.1    Wu, H.2    Li, S.3    Chen, Q.4    Cheng, X.W.5    Zheng, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.