Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes

Cancer Research

Volumn 65, Issue 16, 2005, Pages 7137-7144

  Coxon, Amy ^a   Rozenblum, Ester ^a   Park, Yoon Soo ^a   Joshi, Nina ^a   Tsurutani, Junji ^a   Dennis, Phillip A ^a   Kirsch, Ilan R ^a   Kaye, Frederic J ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOXYCYCLINE; GEFITINIB; ILOMASTAT; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NOTCH RECEPTOR;

ADENOSQUAMOUS CARCINOMA; ARTICLE; CARCINOGENESIS; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 19; CONTROLLED STUDY; EPITHELIUM CELL; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUSION; GENE TARGETING; GENETIC LINKAGE; HUMAN; HUMAN CELL; LUNG TUMOR; MALIGNANT TRANSFORMATION; MAML2 GENE; MECT1 GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND TUMOR; TRANSCRIPTION REGULATION; TREATMENT OUTCOME; VALIDATION PROCESS;

CARCINOMA, MUCOEPIDERMOID; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOXYCYCLINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; LUNG NEOPLASMS; ONCOGENE PROTEINS, FUSION; PROTEIN STRUCTURE, TERTIARY; SALIVARY GLAND NEOPLASMS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 23844523415     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1125     Document Type: Article

References (50)

1. Tonon G, Modi S, Wu L, et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 2003;33:208-13.
2. Enlund F, Behboudi A, Andren Y, et al. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res 2004;292: 21-8.
3. Mitelman F. Recurrent chromosome aberrations in cancer. Mutat Res 2000;462:247-53.
4. Mitelman F, Johansson B, Mertens F. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet 2004;36:331-4.
5. Speight PM, Barrett AW. Salivary gland tumours. Oral Dis 2002;8:229-40.
6. Zheng T, Holford TR, Chen Y, et al. Are cancers of the salivary gland increasing? Experience from Connecticut, USA. Int J Epidemiol 1997;26:264-71.
7. Behboudi A, Winnes M, Gorunova L, et al. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer 2005;43:202-5.
8. Shrestha P, Huang JW, Tsuji T, et al. Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: an immunohistochemical study. J Oral Pathol Med 1992;21: 477-80.
9. Sugano S, Mukai K, Tsuda H, et al. Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness. Laryngoscope 1992;102:923-7.
10. Soini Y, Kamel D, Nuorva K, Lane DP, Vahakangas K, Paakko P. Low p53 protein expression in salivary gland tumours compared with lung carcinomas. Virchows Arch A Pathol Anat Histopathol 1992;421:415-20.
11. Yoo J, Robinson RA. H-ras gene mutations in salivary gland mucoepidermoid carcinomas. Cancer 2000;88: 518-23.
12. Martins C, Cavaco B, Tonon G, Kaye FJ, Soares J, Fonseca I. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. J Mol Diagn 2004;6:205-10.
13. Conkright MD, Canettieri G, Screaton R, et al. TORCs: transducers of regulated CREB activity. Mol Cell 2003;12: 413-23.
14. Iourgenko V, Zhang W, Mickanin C, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A 2003;100:12147-52.
15. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 2000;26:484-9.
16. Cho-Chung YS. CRE-enhancer DNA decoy, a tumor target-based genetic tool. Ann N Y Acad Sci 2003;1002: 124-33.
17. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268:1766-9.
18. Shimizu E, Coxon A, Otterson GA, et al. RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 1994;9:2441-8.
19. Wright GW, Simon RM. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 2003;19:2448-55.
20. Simon R, Korn E, McShane L, Radmacher M, Wright G, Zhao Y. Design and analysis of DNA microarray investigations. New York: Springer-Verlag; 2003.
21. Bittinger MA, McWhinnie E, Meltzer J, et al. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr Biol 2004;14:2156-61.
22. Impey S, McCorkle SR, Cha-Molstad H, et al. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 2004;119:1041-54.
23. Conkright MD, Guzman E, Flechner L, Su AI, Hogenesch JB, Montminy M. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell 2003;11:1101-8.
24. Johansson CC, Yndestad A, Enserink JM, Ree AH, Aukrust P, Tasken K. The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3′,5′-monophosphate pathway in various cell types. Endocrinology 2004;145:5177-84.
25. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001;2:599-609.
26. Ringler GE, Strauss JF III. In vitro systems for the study of human placental endocrine function. Endocr Rev 1990;11:105-23.
27. Hershko DD, Robb BW, Luo G, Hasselgren PO. Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells. Am J Physiol Regul Integr Comp Physiol 2002;283: R1140-8.
28. Sassone-Corsi P. Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation. Proc Natl Acad Sci U S A 1988;85: 7192-6.
29. Janknecht R, Cahill MA, Nordheim A. Signal integration at the c-fos promoter. Carcinogenesis 1995;16:443-50.
30. Van Themsche C, Alain T, Kossakowska AE, Urbanski S, Potworowski EF, St-Pierre Y. Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo. J Immunol 2004;173:3605-11.
31. Voronova AF, Lee F. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by 1d proteins during interleukin 6-induced myeloid differentiation. Proc Natl Acad Sci U S A 1994;91:5952-6.
32. Zhang X, Odom DT, Koo SH, et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A 2005;102: 4459-64.
33. Asahara H, Santoso B, Guzman E, et al. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Mol Cell Biol 2001;21:7892-900.
34. Clark J, Benjamin H, Gill S, et al. Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene 1996;12:229-35.
35. Gill JH, Kirwan IG, Seargent JM, et al. MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas. Neoplasia 2004;6:777-85.
36. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4:891-9.
37. Trikha M, Corringham R, Klein B, Rossi JF. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 2003;9:4653-65.
38. Rosel M, Claas C, Seiter S, Herlevsen M, Zoller M. Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Oncogene 1998;17: 1989-2002.
39. Berquin IM, Dziubinski ML, Nolan GP, Ethier SP. A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene 2001;20: 4019-28.
40. Polosa R, Prosperini G, Leir SH, Holgate ST, Lackie PM, Davies DE. Expression of c-erbB receptors and ligands in human bronchial mucosa. Am J Respir Cell Mol Biol 1999;20:914-23.
41. Richter A, O'Donnell RA, Powell RM, et al. Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke. Am J Respir Cell Mol Biol 2002;27:85-90.
42. Engelman JA, Janne PA, Mermel C, et al. ErbB-3 mediates phosphoinositide 3 kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A 2005;102:3788-93.
43. Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
44. Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
45. Deshmukh HS, Case LM, Wesselkamper SC, et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med 2005;171:305-14.
46. Stenman G, Petursdottir V, Mellgren G, Mark J. A child with a t(11;19)(q14-21;p12) in a pulmonary mucoepidermoid carcinoma. Virchows Arch 1998;433: 579-81.
47. El-Naggar AK, Lovell M, Killary AM, Clayman GL, Batsakis JG. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet 1996;87:29-33.
48. Nagashima AC, Giacomini D, Castro CP, et al. Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells. Mol Cell Endocrinol 2003;201:47-56.
49. Yang YL, Chuang LY, Guh JY, et al. Thrombospondin-1 mediates distal tubule hypertrophy induced by glycated albumin. Biochem J 2004;379:89-97.
50. Chandra G, Cogswell JP, Miller LR, et al. Cyclic AMP signaling pathways are important in IL-1 β transcriptional regulation. J Immunol 1995;155:4535-43.