Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma

Human Pathology

Volumn 40, Issue 6, 2009, Pages 854-860

  Achcar, Rosane De Oliveira Duarte ^a   Nikiforova, Marina N ^a   Dacic, Sanja ^a   Nicholson, Andrew G ^b   Yousem, Samuel A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Gene rearrangement; Molecular changes; Mucoepidermoid carcinoma

Indexed keywords

GENE PRODUCT; MAMMALIAN MASTERMIND LIKE 2; UNCLASSIFIED DRUG;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; BRONCHOPULMONARY MUCOEPIDERMOID CARCINOMA; CHROMOSOME 11Q; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE FUSION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MALE; MAML3 GENE; MECT1 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSARCOMA; ADULT; AGED; AGED, 80 AND OVER; BRONCHIAL NEOPLASMS; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, MUCOEPIDERMOID; CARCINOMA, SQUAMOUS CELL; DNA-BINDING PROTEINS; FEMALE; GENE FUSION; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 67349263518     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2008.11.007     Document Type: Article

References (23)

1. In: Travis W., Brambilla E., Muller-Hermlink H., and Harris C. (Eds). World Health Organization classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart (2004), IARC Press, Lyon 63-64
2. Heitmiller R.F., Mathisen D.J., Ferry J.A., Mark E.J., and Grillo H.C. Mucoepidermoid lung tumors. Ann Thorac Surg 47 (1989) 394-399
3. Vadasz P., and Egervary M. Mucoepidermoid bronchial tumors: a review of 34 operated cases. Eur J Cardiothorac Surg 17 (2000) 566-569
4. Yousem S.A., and Hochholzer L. Mucoepidermoid tumors of the lung. Cancer 60 (1987) 1346-1352
5. Enlund F., Behboudi A., Andren Y., et al. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res 292 (2004) 21-28
6. Tonon G., Modi S., Wu L., et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 33 (2003) 208-213
7. Coxon A., Rozenblum E., Park Y.S., et al. Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res 65 (2005) 7137-7144
8. Wu L., Liu J., Gao P., et al. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J 24 (2005) 2391-2402
9. Aspden L, Seethala R, Dipaola D, Mantha G, Nikiforova M. A novel assay for detection of MECT1/MAML2 translocation in mucoepidermoid carcinomas of the salivary glands. J Mol Diagn 2008;10(6):ST52,610.
10. Conkright M.D., Canettieri G., Screaton R., et al. TORCs: transducers of regulated CREB activity. Mol Cell 12 (2003) 413-423
11. Iourgenko V., Zhang W., Mickanin C., et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A 100 (2003) 12147-12152
12. Shrestha P., Huang J.W., Tsuji T., et al. Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: an immunohistochemical study. J Oral Pathol Med 21 (1992) 477-480
13. Sugano S., Mukai K., Tsuda H., et al. Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness. Laryngoscope 102 (1992) 923-927
14. Soini Y., Kamel D., Nuorva K., et al. Low p53 protein expression in salivary gland tumours compared with lung carcinomas. Virchows Arch A Pathol Anat Histopathol 421 (1992) 415-420
15. Yoo J., and Robinson R.A. H-ras gene mutations in salivary gland mucoepidermoid carcinomas. Cancer 88 (2000) 518-523
16. Martins C., Cavaco B., Tonon G., et al. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. J Mol Diagn 6 (2004) 205-210
17. Serra A., Schackert H.K., Mohr B., et al. t(11;19)(q21;p12∼p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma. J Pediatr Surg 42 (2007) E23-E29
18. Ross D.A., Huaman J.A., and Barsky S.H. A study of the heterogeneity of the mucoepidermoid tumor and the implication for future therapies. Arch Otolaryngol Head Neck Surg 118 (1992) 1172-1178
19. Behboudi A., Enlund F., Winnes M., et al. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer 45 (2006) 470-481
20. Fehr A., Roser K., Heidorn K., et al. A new type of MAML2 fusion in mucoepidermoid carcinoma. Genes Chromosomes Cancer 47 (2008) 203-206
21. Nemoto N., Suzukawa K., Shimizu S., et al. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer 46 (2007) 813-819
22. Okabe M., Miyabe S., Nagatsuka H., et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res 12 (2006) 3902-3907
23. Tirado Y., Williams M.D., Hanna E.Y., et al. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer 46 (2007) 708-715