-
1
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
Rerks-Ngarm, S. et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N. Engl. J. Med. 361, 2209-2220 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
-
2
-
-
56649105122
-
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial
-
Buchbinder, S. P. et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 372, 1881-1893 (2008).
-
(2008)
Lancet
, vol.372
, pp. 1881-1893
-
-
Buchbinder, S.P.1
-
3
-
-
56649114351
-
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: A case-cohort analysis
-
McElrath, M. J. et al. HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet 372, 1894-1905 (2008).
-
(2008)
Lancet
, vol.372
, pp. 1894-1905
-
-
McElrath, M.J.1
-
4
-
-
13944250922
-
Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
-
Gilbert, P. B. et al. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J. Infect. Dis. 191, 666-677 (2005).
-
(2005)
J. Infect. Dis.
, vol.191
, pp. 666-677
-
-
Gilbert, P.B.1
-
5
-
-
18744363385
-
1 T-cell responses containing replication of the primary virus
-
1 T-cell responses containing replication of the primary virus. Nature 420, 434-439 (2002).
-
(2002)
Nature
, vol.420
, pp. 434-439
-
-
Altfeld, M.1
-
6
-
-
77949409948
-
Targeting early infection to prevent HIV-1 mucosal transmission
-
doi:10.1038/nature08757 this issue
-
Haase, A. T. Targeting early infection to prevent HIV-1 mucosal transmission. Nature doi:10.1038/nature08757 (this issue).
-
Nature
-
-
Haase, A.T.1
-
7
-
-
58149267963
-
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
-
Liu, J. et al. Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature 457, 87-91 (2009).
-
(2009)
Nature
, vol.457
, pp. 87-91
-
-
Liu, J.1
-
8
-
-
67449101823
-
Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge
-
Wilson, N. A. et al. Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge. J. Virol. 83, 6508-6521 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 6508-6521
-
-
Wilson, N.A.1
-
9
-
-
61949216736
-
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
-
Hansen, S. G. et al. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nature Med. 15, 293-299 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 293-299
-
-
Hansen, S.G.1
-
10
-
-
77949347809
-
-
Persistent effector memory CD4 and CD8 T-cell responses were induced in monkeys by CMV vectors expressing SIV Gag, Rev-Tat-Nef and Env, and after repeated low-dose intrarectal challenge with SIV, 4 out of 12 immunized monkeys were protected from systemic spread of infection
-
Persistent effector memory CD4 and CD8 T-cell responses were induced in monkeys by CMV vectors expressing SIV Gag, Rev-Tat-Nef and Env, and after repeated low-dose intrarectal challenge with SIV, 4 out of 12 immunized monkeys were protected from systemic spread of infection.
-
-
-
-
11
-
-
41849127131
-
The spread, treatment, and prevention of HIV-1: Evolution of a global pandemic
-
Cohen, M. S., Hellmann, N., Levy, J. A., DeCock, K. & Lange, J. The spread, treatment, and prevention of HIV-1: evolution of a global pandemic. J. Clin. Invest. 118, 1244-1254 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1244-1254
-
-
Cohen, M.S.1
Hellmann, N.2
Levy, J.A.3
Decock, K.4
Lange, J.5
-
12
-
-
0028181261
-
HIV-1 infection incidence among persons with hemophilia in the United States and western Europe, 1978-1990. Multicenter Hemophilia Cohort Study
-
Kroner, B. L., Rosenberg, P. S., Aledort, L. M., Alvord, W. G. & Goedert, J. J. HIV-1 infection incidence among persons with hemophilia in the United States and western Europe, 1978-1990. Multicenter Hemophilia Cohort Study. J. Acquir. Immune Defic. Syndr. 7, 279-286 (1994).
-
(1994)
J. Acquir. Immune Defic. Syndr.
, vol.7
, pp. 279-286
-
-
Kroner, B.L.1
Rosenberg, P.S.2
Aledort, L.M.3
Alvord, W.G.4
Goedert, J.J.5
-
13
-
-
0030590749
-
Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi Kenya
-
Fowke, K. R. et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 348, 1347-1351 (1996).
-
(1996)
Lancet
, vol.348
, pp. 1347-1351
-
-
Fowke, K.R.1
-
14
-
-
66049139947
-
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection
-
Salazar-Gonzalez, J. F. et al. Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J. Exp. Med. 206, 1273-1289 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1273-1289
-
-
Salazar-Gonzalez, J.F.1
-
15
-
-
34548689151
-
Human immunodeficiency virus controllers: Mechanisms of durable virus control in the absence of antiretroviral therapy
-
Deeks, S. G. & Walker, B. D. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 27, 406-416 (2007).
-
(2007)
Immunity
, vol.27
, pp. 406-416
-
-
Deeks, S.G.1
Walker, B.D.2
-
16
-
-
33646869319
-
1 T cell help distinguishes HIV-2 from HIV-1 infection
-
1 T cell help distinguishes HIV-2 from HIV-1 infection. J. Immunol. 176, 6973-6981 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 6973-6981
-
-
Duvall, M.G.1
-
17
-
-
68349157582
-
Toward an AIDS vaccine: Lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts
-
Sodora, D. L. et al. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nature Med. 15, 861-865 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 861-865
-
-
Sodora, D.L.1
-
18
-
-
34249802335
-
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
-
Martin, M. P. et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nature Genet. 39, 733-740 (2007).
-
(2007)
Nature Genet.
, vol.39
, pp. 733-740
-
-
Martin, M.P.1
-
19
-
-
70849099812
-
1 T-cell help
-
1 T-cell help. Nature 462, 510-513 (2009). In a murine HSV-2 infection model, it is shown that CD4 T-helper cells control migration of CD8 T cells to the mucosa through secretion of IFN-c and induction of local secretion of chemokines.
-
(2009)
Nature
, vol.462
, pp. 510-513
-
-
Nakanishi, Y.1
Lu, B.2
Gerard, C.3
Iwasaki, A.4
-
20
-
-
0037007670
-
1 T cells
-
1 T cells. Nature 417, 95-98 (2002).
-
(2002)
Nature
, vol.417
, pp. 95-98
-
-
Douek, D.C.1
-
21
-
-
45749156336
-
1 T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys
-
1 T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. J. Clin. Invest. 118, 2039-2049 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2039-2049
-
-
Klatt, N.R.1
-
22
-
-
0031927204
-
1 T cells in controlling retrovirus replication and spread in persistently infected mice
-
1 T cells in controlling retrovirus replication and spread in persistently infected mice. J. Virol. 72, 6559-6564 (1998).
-
(1998)
J. Virol.
, vol.72
, pp. 6559-6564
-
-
Hasenkrug, K.J.1
Brooks, D.M.2
Dittmer, U.3
-
23
-
-
67649660551
-
Redefining chronic viral infection
-
Virgin, H. W., Wherry, E. J. & Ahmed, R. Redefining chronic viral infection. Cell 138, 30-50 (2009).
-
(2009)
Cell
, vol.138
, pp. 30-50
-
-
Virgin, H.W.1
Wherry, E.J.2
Ahmed, R.3
-
25
-
-
70350316079
-
1 T-cell response determines the outcome of acute friend virus infection
-
1 T-cell response determines the outcome of acute friend virus infection. J. Virol. 83 11211-11222 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 11211-11222
-
-
Pike, R.1
-
26
-
-
67650457719
-
1 lymphocyte depletion but does not account for accelerated SIV pathogenesis
-
1 lymphocyte depletion but does not account for accelerated SIV pathogenesis. J. Exp. Med. 206, 1575-1588 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1575-1588
-
-
Okoye, A.1
-
27
-
-
63849131879
-
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
-
Scheid, J. F. et al. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature 458, 636-640 (2009).
-
(2009)
Nature
, vol.458
, pp. 636-640
-
-
Scheid, J.F.1
-
28
-
-
63449126562
-
Quantitative 3D video microscopy of HIV transfer across T cell virological synapses
-
Hübner, W. et al. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science 323, 1743-1747 (2009).
-
(2009)
Science
, vol.323
, pp. 1743-1747
-
-
Hübner, W.1
-
29
-
-
70349887757
-
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
-
Walker, L. M. et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 326, 285-289 (2009). Using a high-throughput screening method, two potent and broadly cross-reactive neutralizing antibodies were isolated that target a novel broadly neutralizing epitope expressed on trimeric envelope protein and spanning conserved regions of variable loops of the gp120 subunit.
-
(2009)
Science
, vol.326
, pp. 285-289
-
-
Walker, L.M.1
-
30
-
-
12144289425
-
Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission
-
Derdeyn, C. A. et al. Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission. Science 303, 2019-2022 (2004).
-
(2004)
Science
, vol.303
, pp. 2019-2022
-
-
Derdeyn, C.A.1
-
31
-
-
70450182950
-
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120
-
Chen, L. et al. Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. Science 326, 1123-1127 (2009).
-
(2009)
Science
, vol.326
, pp. 1123-1127
-
-
Chen, L.1
-
32
-
-
68349160853
-
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
-
Hessell, A. J. et al. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nature Med. 15, 951-954 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 951-954
-
-
Hessell, A.J.1
-
33
-
-
67249131966
-
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
-
Hessell, A. J. et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. 5, e1000433 (2009).
-
(2009)
PLoS Pathog.
, vol.5
-
-
Hessell, A.J.1
-
34
-
-
68349150945
-
Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
-
Johnson, P. R. et al. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nature Med. 15, 901-906 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 901-906
-
-
Johnson, P.R.1
-
35
-
-
44449143037
-
Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization
-
Nelson, S. et al. Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization. PLoS Pathog. 4, e1000060 (2008).
-
(2008)
PLoS Pathog.
, vol.4
-
-
Nelson, S.1
-
36
-
-
65749107719
-
HIV-1 and influenza antibodies: Seeing antigens in new ways
-
Kwong, P. D. & Wilson, I. A. HIV-1 and influenza antibodies: seeing antigens in new ways. Nature Immunol. 10, 573-578 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 573-578
-
-
Kwong, P.D.1
Wilson, I.A.2
-
37
-
-
34548496893
-
Fc receptor but not complement binding is important in antibody protection against HIV
-
Hessell, A. J. et al. Fc receptor but not complement binding is important in antibody protection against HIV. Nature 449, 101-104 (2007).
-
(2007)
Nature
, vol.449
, pp. 101-104
-
-
Hessell, A.J.1
-
38
-
-
4344685877
-
Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection
-
Messer, R. J., Dittmer, U., Peterson, K. E. & Hasenkrug, K. J. Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection. Proc. Natl Acad. Sci. USA 101, 12260-12265 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 12260-12265
-
-
Messer, R.J.1
Dittmer, U.2
Peterson, K.E.3
Hasenkrug, K.J.4
-
39
-
-
0027151892
-
Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis
-
Tyler, K. L., Mann, M. A., Fields, B. N. & Virgin, H. W. Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis. J. Virol. 67, 3446-3453 (1993).
-
(1993)
J. Virol.
, vol.67
, pp. 3446-3453
-
-
Tyler, K.L.1
Mann, M.A.2
Fields, B.N.3
Virgin, H.W.4
-
40
-
-
19944405462
-
Complement activation is required for induction of a protective antibody response against West Nile virus infection
-
Mehlhop, E. et al. Complement activation is required for induction of a protective antibody response against West Nile virus infection. J.Virol.79, 7466-7477 (2005).
-
(2005)
J.Virol.
, vol.79
, pp. 7466-7477
-
-
Mehlhop, E.1
-
41
-
-
33746617565
-
Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses
-
McClellan, K. B., Gangappa, S., Speck, S. H. & Virgin, H. W. Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses. PLoS Pathog. 2, e58 (2006).
-
(2006)
PLoS Pathog.
, vol.2
-
-
McClellan, K.B.1
Gangappa, S.2
Speck, S.H.3
Virgin, H.W.4
-
42
-
-
0028785569
-
Passive immunotherapy for retroviral disease: Influence of major histocompatibility complex type and T-cell responsiveness
-
Hasenkrug, K. J., Brooks, D. M. & Chesebro, B. Passive immunotherapy for retroviral disease: influence of major histocompatibility complex type and T-cell responsiveness. Proc. Natl Acad. Sci. USA 92, 10492-10495 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 10492-10495
-
-
Hasenkrug, K.J.1
Brooks, D.M.2
Chesebro, B.3
-
43
-
-
33846101731
-
1 T-cell responses to different HIV proteins have discordant associations with viral load
-
1 T-cell responses to different HIV proteins have discordant associations with viral load. Nature Med. 13, 46-53 (2007).
-
(2007)
Nature Med.
, vol.13
, pp. 46-53
-
-
Kiepiela, P.1
-
44
-
-
33846497834
-
1 T cells suppress simian immunodeficiency virus replication
-
1 T cells suppress simian immunodeficiency virus replication. J. Virol. 81, 1517-1523 (2007).
-
(2007)
J. Virol.
, vol.81
, pp. 1517-1523
-
-
Chung, C.1
-
45
-
-
63149194225
-
Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes
-
Chen, H. et al. Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes. J. Virol. 83, 3138-3149 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 3138-3149
-
-
Chen, H.1
-
46
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
Day, C. L. et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443, 350-354 (2006).
-
(2006)
Nature
, vol.443
, pp. 350-354
-
-
Day, C.L.1
-
47
-
-
33749338938
-
1 T cell survival in HIV infection
-
1 T cell survival in HIV infection. J. Exp. Med. 203, 2281-2292 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2281-2292
-
-
Petrovas, C.1
-
48
-
-
33749009709
-
1 T cells leads to reversible immune dysfunction
-
1 T cells leads to reversible immune dysfunction. Nature Med. 12, 1198-1202 (2006).
-
(2006)
Nature Med.
, vol.12
, pp. 1198-1202
-
-
Trautmann, L.1
-
49
-
-
34548680261
-
1 T cells correlates with disease progression and defines a reversible immune dysfunction
-
1 T cells correlates with disease progression and defines a reversible immune dysfunction. Nature Immunol. 8, 1246-1254 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 1246-1254
-
-
Kaufmann, D.E.1
-
50
-
-
57849085182
-
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
-
Querec, T. D. et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nature Immunol. 10, 116-125 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 116-125
-
-
Querec, T.D.1
-
51
-
-
46049112339
-
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
-
Moir, S. et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J. Exp. Med. 205, 1797-1805 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1797-1805
-
-
Moir, S.1
-
52
-
-
63149142646
-
B cells in HIV infection and disease
-
Moir, S. & Fauci, A. S. B cells in HIV infection and disease. Nature Rev. Immunol. 9, 235-245 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 235-245
-
-
Moir, S.1
Fauci, A.S.2
-
53
-
-
41149130734
-
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
-
Brooks, D. G., Lee, A. M., Elsaesser, H., McGavern, D. B. & Oldstone, M. B. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J. Exp. Med. 205, 533-541 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 533-541
-
-
Brooks, D.G.1
Lee, A.M.2
Elsaesser, H.3
McGavern, D.B.4
Oldstone, M.B.5
-
54
-
-
58149484842
-
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
-
Brooks, D. G. et al. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc. Natl Acad. Sci. USA 105, 20428-20433 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 20428-20433
-
-
Brooks, D.G.1
-
56
-
-
67649234772
-
IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
-
Fröhlich, A. et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324, 1576-1580 (2009).
-
(2009)
Science
, vol.324
, pp. 1576-1580
-
-
Fröhlich, A.1
-
57
-
-
67649217469
-
IL-21 is required to control chronic viral infection
-
Elsaesser, H., Sauer, K. & Brooks, D. G. IL-21 is required to control chronic viral infection. Science 324, 1569-1572 (2009).
-
(2009)
Science
, vol.324
, pp. 1569-1572
-
-
Elsaesser, H.1
Sauer, K.2
Brooks, D.G.3
-
58
-
-
67649203681
-
A vital role for interleukin-21 in the control of a chronic viral infection
-
Yi, J. S., Du, M. & Zajac, A. J. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324, 1572-1576 (2009).
-
(2009)
Science
, vol.324
, pp. 1572-1576
-
-
Yi, J.S.1
Du, M.2
Zajac, A.J.3
-
59
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber, D. L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
-
(2006)
Nature
, vol.439
, pp. 682-687
-
-
Barber, D.L.1
-
60
-
-
62249172189
-
Enhancing SIV-specific immunity in vivo by PD-1 blockade
-
Velu, V. et al. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458, 206-210 (2008).
-
(2008)
Nature
, vol.458
, pp. 206-210
-
-
Velu, V.1
-
61
-
-
41149112957
-
Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection
-
Ha, S. J. et al. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J. Exp. Med. 205, 543-555 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 543-555
-
-
Ha, S.J.1
-
62
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009).
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
-
63
-
-
11144283687
-
Therapeutic dendritic-cell vaccine for chronic HIV-1 infection
-
Lu, W., Arraes, L. C., Ferreira, W. T. & Andrieu, J. M. Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nature Med. 10, 1359-1365 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 1359-1365
-
-
Lu, W.1
Arraes, L.C.2
Ferreira, W.T.3
Andrieu, J.M.4
-
64
-
-
45849153869
-
Coordination of early protective immunity to viral infection by regulatory T cells
-
Lund, J. M., Hsing, L., Pham, T. T. & Rudensky, A. Y. Coordination of early protective immunity to viral infection by regulatory T cells. Science 320, 1220-1224 (2008).
-
(2008)
Science
, vol.320
, pp. 1220-1224
-
-
Lund, J.M.1
Hsing, L.2
Pham, T.T.3
Rudensky, A.Y.4
-
65
-
-
33947424353
-
1 T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
-
1 T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J. Exp. Med. 204, 595-603 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 595-603
-
-
Zhu, J.1
-
66
-
-
65249134069
-
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
-
Gebhardt, T. et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nature Immunol. 10, 524-530 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 524-530
-
-
Gebhardt, T.1
-
67
-
-
58149229682
-
Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection
-
Chachu, K. A., LoBue, A. D., Strong, D. W., Baric, R. S. & Virgin, H. W. Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection. PLoS Pathog. 4, e1000236 (2008).
-
(2008)
PLoS Pathog.
, vol.4
-
-
Chachu, K.A.1
Lobue, A.D.2
Strong, D.W.3
Baric, R.S.4
Virgin, H.W.5
-
68
-
-
67651049056
-
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): Final analysis of a double-blind, randomised study in young women
-
Paavonen, J. et al. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet 374, 301-314 (2009).
-
(2009)
Lancet
, vol.374
, pp. 301-314
-
-
Paavonen, J.1
-
69
-
-
56149112944
-
1 T lymphocytes to mucosal surfaces following intramuscular vaccination
-
1 T lymphocytes to mucosal surfaces following intramuscular vaccination. J. Immunol. 181, 4188-4198 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 4188-4198
-
-
Kaufman, D.R.1
-
70
-
-
34249005003
-
Herpesvirus latency confers symbiotic protection from bacterial infection
-
Barton, E. S. et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447, 326-329 (2007).
-
(2007)
Nature
, vol.447
, pp. 326-329
-
-
Barton, E.S.1
-
71
-
-
0032849066
-
Protection by live, attenuated simian immunodeficiency virus against heterologous challenge
-
Wyand, M. S. et al. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. J. Virol. 73, 8356-8363 (1999).
-
(1999)
J. Virol.
, vol.73
, pp. 8356-8363
-
-
Wyand, M.S.1
-
72
-
-
33845532053
-
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
-
Brenchley, J. M. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Med. 12, 1365-1371 (2006).
-
(2006)
Nature Med.
, vol.12
, pp. 1365-1371
-
-
Brenchley, J.M.1
-
73
-
-
68149091349
-
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
-
Slack, E. et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325, 617-620 (2009).
-
(2009)
Science
, vol.325
, pp. 617-620
-
-
Slack, E.1
-
74
-
-
53649088464
-
Identification of enteroviruses in naturally infected captive primates
-
Nix, W. A., Jiang, B., Maher, K., Strobert, E. & Oberste, M. S. Identification of enteroviruses in naturally infected captive primates. J. Clin. Microbiol. 46, 2874-2878 (2008).
-
(2008)
J. Clin. Microbiol.
, vol.46
, pp. 2874-2878
-
-
Nix, W.A.1
Jiang, B.2
Maher, K.3
Strobert, E.4
Oberste, M.S.5
-
75
-
-
40349087269
-
Metagenomic analysis of human diarrhea: Viral detection and discovery
-
Finkbeiner, S. R. et al. Metagenomic analysis of human diarrhea: viral detection and discovery. PLoS Pathog. 4, e1000011 (2008).
-
(2008)
PLoS Pathog.
, vol.4
-
-
Finkbeiner, S.R.1
-
76
-
-
40349113425
-
The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis
-
McKenna, P. et al. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS Pathog. 4, e20 (2008).
-
(2008)
PLoS Pathog.
, vol.4
-
-
McKenna, P.1
-
77
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
-
78
-
-
69249211230
-
T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces
-
Korber, B. T., Letvin, N. L. & Haynes, B. F. T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces. J. Virol. 83, 8300-8314 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 8300-8314
-
-
Korber, B.T.1
Letvin, N.L.2
Haynes, B.F.3
-
79
-
-
44649102135
-
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
-
Keele, B. F. et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc. Natl Acad. Sci. USA 105, 7552-7557 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 7552-7557
-
-
Keele, B.F.1
-
80
-
-
31144465690
-
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
-
Vignuzzi, M., Stone, J. K., Arnold, J. J., Cameron, C. E. & Andino, R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 439, 344-348 (2006).
-
(2006)
Nature
, vol.439
, pp. 344-348
-
-
Vignuzzi, M.1
Stone, J.K.2
Arnold, J.J.3
Cameron, C.E.4
Andino, R.5
-
81
-
-
33645086391
-
Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
-
Draenert, R. et al. Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus. J. Exp. Med. 203, 529-539 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 529-539
-
-
Draenert, R.1
-
82
-
-
0037165969
-
Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
-
Moore, C. B. et al. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296, 1439-1443 (2002).
-
(2002)
Science
, vol.296
, pp. 1439-1443
-
-
Moore, C.B.1
-
83
-
-
68949209789
-
HLA-associated immune escape pathways in HIV-1 subtype B Gag
-
Brumme, Z. L. et al. HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. PLoS One 4, e6687 (2009).
-
(2009)
Pol and Nef Proteins. PLoS One
, vol.4
-
-
Brumme, Z.L.1
-
84
-
-
62749177486
-
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition
-
Miura, T. et al. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition. J. Virol. 83, 2743-2755 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 2743-2755
-
-
Miura, T.1
-
85
-
-
84857959077
-
Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response
-
Troyer, R. M. et al. Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response. PLoS Pathog. 5, e1000365 (2009).
-
(2009)
PLoS Pathog.
, vol.5
-
-
Troyer, R.M.1
-
86
-
-
43949094512
-
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
-
Schneidewind, A. et al. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J. Virol. 82, 5594-5605 (2008).
-
(2008)
J. Virol.
, vol.82
, pp. 5594-5605
-
-
Schneidewind, A.1
-
88
-
-
2942672080
-
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection
-
Allen, T. M. et al. Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J. Virol. 78, 7069-7078 (2004).
-
(2004)
J. Virol.
, vol.78
, pp. 7069-7078
-
-
Allen, T.M.1
-
89
-
-
67449147145
-
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
-
Goonetilleke, N. et al. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med. 206, 1253-1272 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1253-1272
-
-
Goonetilleke, N.1
-
90
-
-
64049111619
-
Transmission and long-term stability of compensated CD8 escape mutations
-
Schneidewind, A. et al. Transmission and long-term stability of compensated CD8 escape mutations. J. Virol. 83, 3993-3997 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 3993-3997
-
-
Schneidewind, A.1
-
91
-
-
33846111016
-
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
-
Fischer, W. et al. Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature Med. 13, 100-106 (2007).
-
(2007)
Nature Med.
, vol.13
, pp. 100-106
-
-
Fischer, W.1
-
92
-
-
70349235715
-
Restriction factors, and interferon
-
Neil, S. & Bieniasz, P. HIV, restriction factors, and interferon. J Interferon. Cytokine. Res. 29, 569-580 (2009).
-
(2009)
J Interferon. Cytokine. Res.
, vol.29
, pp. 569-580
-
-
Neil, S.1
Hiv, B.P.2
-
93
-
-
67249143012
-
Host cell factors in HIV replication: Meta-analysis of genome-wide studies
-
Bushman, F. D. et al. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog. 5, e1000437 (2009).
-
(2009)
PLoS Pathog.
, vol.5
-
-
Bushman, F.D.1
-
94
-
-
51149120614
-
Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection
-
Santiago, M. L. et al. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321, 1343-1346 (2008).
-
(2008)
Science
, vol.321
, pp. 1343-1346
-
-
Santiago, M.L.1
-
95
-
-
0037043699
-
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
-
Sheehy, A. M., Gaddis, N. C., Choi, J. D. & Malim, M. H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418, 646-650 (2002).
-
(2002)
Nature
, vol.418
, pp. 646-650
-
-
Sheehy, A.M.1
Gaddis, N.C.2
Choi, J.D.3
Malim, M.H.4
-
96
-
-
0344413641
-
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
-
Sheehy, A. M., Gaddis, N. C. & Malim, M. H. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Nature Med. 9, 1404-1407 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1404-1407
-
-
Sheehy, A.M.1
Gaddis, N.C.2
Malim, M.H.3
-
97
-
-
69449083091
-
A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
-
Dinoso, J. B. et al. A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J. Virol. 83, 9247-9257 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 9247-9257
-
-
Dinoso, J.B.1
-
98
-
-
70049090006
-
CpG methylation controls reactivation of HIV from latency
-
Blazkova, J. et al. CpG methylation controls reactivation of HIV from latency. PLoS Pathog. 5, e1000554 (2009).
-
(2009)
PLoS Pathog.
, vol.5
-
-
Blazkova, J.1
-
99
-
-
44349103540
-
Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells
-
Zhang, J. X., Diehl, G. E. & Littman, D. R. Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells. PLoS One 3, e2035 (2008).
-
(2008)
PLoS One
, vol.3
-
-
Zhang, J.X.1
Diehl, G.E.2
Littman, D.R.3
-
100
-
-
63149135737
-
A macaque model of HIV-1 infection
-
Hatziioannou, T. et al. A macaque model of HIV-1 infection. Proc. Natl Acad. Sci. USA 106, 4425-4429 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4425-4429
-
-
Hatziioannou, T.1
-
101
-
-
0036635343
-
Immune control of the number and reactivation phenotype of cells latently infected with a gamma-herpesvirus
-
Tibbetts, S. A., Van Dyk, L., Speck, S. H. & Virgin, H. W. Immune control of the number and reactivation phenotype of cells latently infected with a gamma-herpesvirus. J. Virol. 76, 7125-7132 (2002).
-
(2002)
J. Virol.
, vol.76
, pp. 7125-7132
-
-
Tibbetts, S.A.1
Van Dyk, L.2
Speck, S.H.3
Virgin, H.W.4
-
102
-
-
0028275735
-
AIDS: Time to turn to basic science
-
Fields, B. N. AIDS: time to turn to basic science. Nature 369, 95-96 (1994).
-
(1994)
Nature
, vol.369
, pp. 95-96
-
-
Fields, B.N.1
-
103
-
-
48249134364
-
HIV vaccine research: The way forward
-
Fauci, A.S.et al. HIV vaccine research: the way forward. Science 321 530-532 (2008).
-
(2008)
Science
, vol.321
, pp. 530-532
-
-
Fauci, A.S.1
|