Conference report: building a biologic pacemaker

Journal of Electrocardiology

Volumn 40, Issue 6 SUPPL. 1, 2007, Pages

  Rosen, Michael R ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Gene therapy; HCN channels; Mesenchymal stem cells

Indexed keywords

VIRUS VECTOR;

ARTICLE; CELL LINEAGE; ELECTRODE; EMBRYONIC STEM CELL; ENGINEERING; GAP JUNCTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; INDWELLING CATHETER; MESENCHYMAL STEM CELL; MONITORING; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; SINUS NODE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BIOLOGICAL CLOCKS; GENETIC ENGINEERING; HEART CONDUCTION SYSTEM; HUMANS; MYOCYTES, CARDIAC; TISSUE ENGINEERING;

EID: 35748955208     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2007.05.028     Document Type: Article

References (14)

1. Biel M., Schneider A., and Wahl C. Cardiac HCN channels: structure, function, and modulation. Trends Cardiovasc Med 12 (2002) 202
2. Rosen M.R., Brink P.R., Cohen I.S., and Robinson R.B. Genes, stem cells and biological pacemakers. Cardiovasc Res 64 (2004) 12
3. Edelberg J.M., Aird W.C., and Rosenberg R.D. Enhancement of murine cardiac chronotropy by the molecular transfer of the human β2-adrenergic receptor cDNA. J Clin Invest 101 (1998) 337
4. Edelberg J.M., Huang D.T., Josephson M.E., and Rosenberg R.D. Molecular enhancement of porcine cardiac chronotropy. Heart 86 (2001) 559
5. Miake J., Marbán E., and Nuss H.B. Gene therapy: biological pacemaker created by gene transfer. Nature 419 (2002) 132
6. Qu J., Plotnikov A.N., Danilo Jr. P., et al. Expression and function of a biological pacemaker in canine heart. Circulation 107 (2003) 1106
7. Plotnikov A.N., Sosunov E.A., Qu J., et al. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation 109 (2004) 506
8. Kehat I., Khimovich L., Caspi O., et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22 (2004) 1282
9. Potapova I., Plotnikov A., Lu Z., et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res 94 (2004) 952
10. Bucchi A., Plotnikov A.N., Shlapakova I., et al. Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker. Circulation 114 (2006) 992
11. Tse H.F., Xue T., Lau C.P., et al. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation 114 (2006) 1000
12. Kashiwakura Y., Cho H.C., Barth A.S., Azene E., and Marban E. Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation 114 (2006) 1682
13. Plotnikov A.N., Shlapakova I.N., Szabolcs M.J., et al. Adult human mesenchymal stem cells carrying HCN2 gene perform biological pacemaker function with no overt rejection for 6 weeks in canine heart. Circulation 112 (2005) II-221
14. f blockade with ivabradine. Circulation 114 (2006) II-123