Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: Heterogeneity of role and control

Journal of Physiology

Volumn 556, Issue 2, 2004, Pages 481-494

  Lancaster, Matthew K ^a   Jones, Sandra A ^a   Harrison, Simon M ^a   Boyett, Mark R ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); REGULATOR PROTEIN; RYANODINE; SODIUM CALCIUM EXCHANGE PROTEIN; ANILINE DERIVATIVE; BUFFER; CALCIUM; FLUO 3; FLUORESCENT DYE; XANTHENE DERIVATIVE; ADENOSINE TRIPHOSPHATASE; CALCIUM ION;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL SIZE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DIASTOLE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; REGULATORY MECHANISM; SARCOLEMMA; SARCOPLASMIC RETICULUM; SINOATRIAL CONDUCTION; SINUS NODE; SYSTOLE; ANIMAL; BIOLOGICAL RHYTHM; CYTOLOGY; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; CELL ACTIVITY; CELL ASSAY; CELL HETEROGENEITY; ENZYME ASSAY; MEASUREMENT; MOLECULAR DYNAMICS; PROTEIN LOCALIZATION; SINUS NODE MEMBRANE POTENTIAL; SODIUM CALCIUM EXCHANGE;

ANILINE COMPOUNDS; ANIMALS; BIOLOGICAL CLOCKS; BUFFERS; CALCIUM; CELL SIZE; CYTOSOL; FLUORESCENT DYES; RABBITS; RYANODINE; SARCOPLASMIC RETICULUM; SINOATRIAL NODE; XANTHENES;

EID: 2342617480     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.057372     Document Type: Article

References (28)

1. Bassani JW, Bassani RA & Bers DM (1994). Relaxation in rabbit and rat cardiac cells: species-dcpendent differences in cellular mechanisms. J Physiol 476, 279-293.
2. i in intact rabbit cardiac myocytes. Biophys J 68, 1453-1460.
3. Bassani RA, Bassani JW, Lipsius SL & Bers DM (1997). Diastolic SR Ca efflux in atrial pacemaker cells and Ca-overloaded myocytes. Am J Physiol 273, H886-H892.
4. Bassani JW, Godoy CM & Bassani RA (1999). Effect of ryanodine on sinus node recovery time determined in vitro. Braz J Med Biol Res 32, 1039-1043.
5. Bleeker WK, Mackaay AJ, Masson-Pevet M, Bouman LN & Becker AE (1980). Functional and morphological organization of the rabbit sinus node. Circ Res 46, 11-22.
6. 2+ exchanger: molecular partners in pacemaker regulation. Circ Res 88, 1254-1258.
7. Boyett MR, Honjo H & Kodama I (2000). The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res 47, 658-687.
8. Boyett MR, Honjo H, Yamamoto M, Nikmaram MR, Niwa R & Kodama I (1998). Regional differences in effects of 4-aminopyridine within the sinoatrial node. Am J Physiol 275, H1158-H1168.
9. DiFrancesco D & Robinson RB (2002). Beta-modulation of pacemaker rate: novel mechanism or novel mechanics of an old one? Circ Res 90, E69.
10. 2+ release from sarcoplasmic reticulum in the regulation of sinoatrial node automaticity. Heart Vessels 11, 234-241.
11. Honjo H, Boyett MR, Kodama I & Toyama J (1996). Correlation between electrical activity and the size of rabbit sino-atrial node cells. J Physiol 496, 795-808.
12. 2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ Res 92, e41-e44.
13. Honjo H, Lei M, Boyett MR & Kodama I (1999). Heterogeneity of 4-aminopyridine-sensitive current in rabbit sinoatrial node cells. Am J Physiol 276, H1295-H1304.
14. 2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol 524, 415-422.
15. Kirchhof CJ, Bonke FI & Allessie MA (1988). Evidence for the presence of electrotonic depression of pacemakers in the rabbit atrioventricular node. The effects of uncoupling from the surrounding myocardium. Basic Res Cardiol 83, 190-201.
16. Lakatta EG, Maltsev VA, Bogdanov KY, Stern MD & Vinogradova TM (2003). Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance. Circ Res 92, E45-E50.
17. + current in rabbit sinoatrial node cells. Cardiovasc Res 46, 433-441.
18. Li J, Qu J & Nathan RD (1997). Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node. Am J Physiol 273, H2481-H2489.
19. Lipsius SL (1989). Mechanisms of atrial subsidiary pacemaker function. In Cellular Pathophysiology, ed. Sayeed MM, pp. 1-39. CRC Press, Boca Raton, Florida.
20. Masson-Pevet MA, Bleeker WK, Besselsen E, Treytel BW, Jongsma HJ & Bouman LN (1984). Pacemaker cell types in the rabbit sinus node: a correlative ultrastructural and electrophysiological study. J Mol Cell Cardiol 16, 53-63.
21. 2+. Biochem J 269, 513-519.
22. 2+ handling proteins in rabbit sinoatrial node. J Histochem Cytochem 50, 311-324.
23. Opthof T (1988). The mammalian sinoatrial node. Cardiovasc Drugs Ther 1, 573-597.
24. Rigg L & Terrar DA (1996). Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node. Exp Physiol 81, 877-880.
25. Trafford AW, Diaz ME & Eisner DA (1999). A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes. Pflügers Arch 437, 501-503.
26. 2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res 90, 73-79.
27. Vinogradova TM, Bogdanov KY & Lakatta EG (2002b). Novel perspectives on the beating rate of the heart. Circ Res 91, e3.
28. Watanabe EI, Honjo H, Anno T, Boyett MR, Kodama I & Toyama J (1995). Modulation of pacemaker activity of sinoatrial node cells by electrical load imposed by an atrial cell model. Am J Physiol 269, H1735-H1742.