Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 273, Issue 5 42-5, 1997, Pages

  Li, Jin ^a   Qu, Jihong ^a   Nathan, Richard D ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

1,2 bis(2 aminophenoxy)ethane N,N,N',N' tetraacetic acid; Indo 1; L type calcium current; Perforated patch voltage clamp technique; Sodium calcium exchange current; T type calcium current

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; RYANODINE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL MEMBRANE POTENTIAL; CHRONOTROPISM; CONTROLLED STUDY; MALE; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; RABBIT; SARCOPLASMIC RETICULUM; SINUS NODE;

EID: 0030725925     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.273.5.h2481     Document Type: Article

References (14)

1. 2+ is buffered. Circ. Res. 68: 897-902, 1991.
2. si, in the rabbit sinoatrial node investigated by voltage clamp and computer simulation. Proc. R. Soc. Lond. B Biol. Sci. 222: 305-328, 1984.
3. Cohen, N. M., and W. J. Lederer. Changes in the calcium current of rat heart ventricular myocytes during development. J. Physiol. (Lond.) 406: 115-146, 1988.
4. Cohen, C. J., S. Spires, and D. Van Skiver. Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J. Gen. Physiol. 100: 703-728, 1992.
5. Doerr, T., R. Denger, and W. Trautwein. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. P flügers Arch. 413: 599-603, 1989.
6. Earm, Y. E, W. K. Ho, and I. S. So. Inward current generated by Na-Ca exchange during the action potential in single atrial cells of the rabbit. Proc. R. Soc. Land. B Biol. Sci. 240: 61-81, 1990.
7. Escande, D., E. Coraboeuf, and C. Planche. Abnormal pace-making is modulated by sarcoplasmic reticulum in partiallydepolarized myocardium from dilated right atria in humans. J. Mol. Cell. Cardiol. 19: 231-241, 1987.
8. Fermini, B., and R. D. Nathan. Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H735-H743, 1991.
9. Giles, W., and Y. Shimoni. Slow inward tail currents in rabbit cardiac cells. J. Physiol. (Lond.) 417: 447-463, 1989.
10. Guo, J., K. Ono, and, A. Noma. A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells. J. Physiol. (Lond.) 483: 1-13, 1995.
11. Hagiwara, N., and H. Irisawa. Na-Ca exchange current in sinoatrial node cell of rabbit (Abstract). Circulation 78, Suppl. 2: 123, 1988.
12. 2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells. J. Physiol. (Lond.) 409: 121-141, 1989.
13. Hagiwara, N., H. Irisawa, and M. Kameyama. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J. Physiol. (Lond.) 395: 233-253, 1988.
14. Hagiwara, N., H. Irisawa, H. Kasanuki, and B. Hosoda. Background currents in sino-atrial node cells of the rabbit heart. J. Physiol. (Lond.) 448: 53-72, 1992.