Bridged β3-Peptide Inhibitors of p53-hDM2 complexation: Correlation between affinity and cell permeability

Journal of the American Chemical Society

Volumn 132, Issue 9, 2010, Pages 2904-2906

  Bautista, Arjel D ^a   Appelbaum, Jacob S ^b   Craig, Cody J ^a   Michel, Julien ^a   Schepartz, Alanna ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

14-HELIX STRUCTURE; CELL PERMEABILITY; CELL UPTAKE; CELL-PERMEABLE; DIETHERS; HYDROCARBON BRIDGES; PEPTIDE INHIBITORS; PEPTIDOMIMETICS; RESEARCH TOOLS; SECONDARY STRUCTURES;

COMPLEXATION; HYDROCARBONS; LIGANDS; SYNTHESIS (CHEMICAL);

PEPTIDES;

BETA 3 PEPTIDE INHIBITOR; CATION; ETHER DERIVATIVE; HYDROCARBON; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CIRCULAR DICHROISM; COMPLEX FORMATION; COMPUTER MODEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RING CLOSING METATHESIS; X RAY CRYSTALLOGRAPHY;

CELL MEMBRANE PERMEABILITY; COMPUTER SIMULATION; HELA CELLS; HUMANS; PEPTIDES; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77949376261     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja910715u     Document Type: Article

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