Solution structure of a β-peptide ligand for hDM2

Journal of the American Chemical Society

Volumn 127, Issue 12, 2005, Pages 4118-4119

  Kritzer, Joshua A ^a   Hodsdon, Michael E ^b   Schepartz, Alanna ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA PEPTIDE; EPITOPE; LIGAND; ONCOPROTEIN; PEPTIDE; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR PROTEINS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SOLUTIONS;

EID: 16244416846     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja042933r     Document Type: Article

References (25)

1. Kritzer, J. A.; Lear, J. D.; Hodsdon, M. E.; Schepartz, A. J. Am. Chem. Soc. 2004, 126, 9468.
2. Raguse, T. L.; Lai, J. R.; LePlae, P. R.; Gellman, S. H. Org. Lett. 2001, 3, 3963.
3. Cheng, R. P.; DeGrado, W. F. J. Am. Chem. Soc. 2002, 124, 11564.
4. Seebach, D.; Beck, A. K.; Bierbaum, D. J. Chem. Biodiversity 2004, 1, 1111.
5. Cheng, R. P.; Gellman, S. H.; DeGrado, W. F. Chem. Rev. 2001, 101, 3219.
6. Please see Supporting Information for details.
7. ROE intensities were linear in this range.
8. Arvidsson, P. I.; Rueping, M.; Seebach, D. Chem. Commun. 2001, 649.
9. Etezady-Esfarjani, T.; Hilty, C.; Wuthrich, K.; Rueping, M.; Schreiber, J.; Seebach, D. Helv. Chim. Acta 2002, 55, 1197.
10. Goddard, T. D.; Kneller, D. G. SPARKY 3; University of California: San Francisco, CA, 2004.
11. Guntert, P.; Mumenthaler, C.; Wuthrich, K. J. Mol. Biol. 1997, 273, 283.
12. Rueping, M.; Mahajan, Y. R.; Jaun, B.; Seebach, D. Chem.-Eur. J. 2004, 10, 1607.
13. Cheng, R. P.; DeGrado, W. F. J. Am. Chem. Soc. 2001, 123, 5162.
14. Hart, S. A.; Bahadoor, A. B. F.; Matthews, E. E.; Qiu, X. Y. J.; Schepartz, A. J. Am. Chem. Soc. 2003, 125, 4022.
15. Kritzer, J. A.; Tirado-Rives, J.; Hart, S. A.; Lear, J. D.; Jorgensen, W. L.; Schepartz, A. J. Am. Chem. Soc. 2005, 127, 167.
16. Raguse, T. L.; Lai, J. R.; Gellman, S. H. Helv. Chim. Acta 2002, 85, 4154.
17. Hamuro, Y.; Schneider, J. P.; DeGrado, W. F. J. Am. Chem. Soc 1999, 121, 12200.
18. Gung, B. W.; Zou, D.; Stalcup, A. M.; Cottrell, C. E. J. Org. Chem. 1999, 64, 2176.
19. Chakrabartty, A.; Baldwin, R. L. Adv. Protein Chem. 1995, 46, 141.
20. Creighton, T. E. Proteins; W. H. Freeman and Co.: New York, 1993; Vol. p.
21. Martinek, T. A.; Fulop, F. Eur. J. Biochem. 2003, 270, 3657.
22. Glattli, A.; Seebach, D.; van Gunsteren, W. F. Helv. Chim. Acta 2004, 87, 2487.
23. Nooren, I. M. A.; Thornton, J. M. J. Mol. Biol. 2003, 325, 991.
24. Kussie, P. H.; Gorina, S.; Marechal, V.; Elenbaas, B.; Moreau, J.; Levine, A. J.; Pavletich, N. P. Science 1996, 274, 948.
25. Retroinverso peptides are another promising class of metabolically stable mimics for α-helical peptides. For a recent related example, see: Sakurai, K.; Chung, H. S.; Kahne, D. J. Am. Chem. Soc. 2004, 126, 16288.