The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention

Diabetologia

Volumn 53, Issue 3, 2010, Pages 504-509

  Mussig K ^a   Heni, M ^a   Thamer, C ^a   Kantartzis, K ^a   MacHicao, F ^a   Stefan, N ^a   Fritsche, A ^a   Haring, H U ^a   Staiger, H ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1; ENPP1; PC1; Plasma cell membrane glycoprotein 1; SNP; Type 2 diabetes mellitus

Indexed keywords

INSULIN; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; INORGANIC PYROPHOSPHATASE; PHOSPHODIESTERASE;

ADULT; ANTHROPOMETRY; ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN SENSITIVITY; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; FEMALE; GENETIC PREDISPOSITION; GENETICS; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; INTERVENTION STUDY; LIFESTYLE; MALE; MIDDLE AGED; PATHOLOGY; PROCEDURES;

ADULT; ANTHROPOMETRY; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INTERVENTION STUDIES; LIFE STYLE; MALE; MIDDLE AGED; PHOSPHORIC DIESTER HYDROLASES; POLYMORPHISM, GENETIC; PYROPHOSPHATASES;

EID: 77949262297     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1612-4     Document Type: Article

References (33)

1. SE Kahn 2003 The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes Diabetologia 46 3 19 10.1007/s00125-003-1190-9 1:CAS:528:DC%2BD3sXhtVKkt74%3D 12637977
2. S Wild G Roglic A Green R Sicree H King 2004 Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 1047 1053 10.2337/diacare.27.5.1047 15111519 (Pubitemid 38579764)
3. LS Lieberman 2003 Dietary, evolutionary, and modernizing influences on the prevalence of type 2 diabetes Annu Rev Nutr 23 345 377 10.1146/annurev.nutr. 23.011702.073212 1:CAS:528:DC%2BD3sXntFSju7s%3D 12651966 (Pubitemid 37059728)
4. MB Schulze FB Hu 2005 Primary prevention of diabetes: what can be done and how much can be prevented? Annu Rev Public Health 26 445 467 10.1146/annurev.publhealth.26.021304.144532 15760297 (Pubitemid 40547392)
5. P Weyrich N Stefan HU Häring M Laakso A Fritsche 2007 Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes J Mol Med 85 107 117 10.1007/s00109-006-0134-5 17165091 (Pubitemid 46183610)
6. N Stefan C Thamer H Staiger, et al. 2007 Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention J Clin Endocrinol Metab 92 1827 1833 10.1210/jc.2006-1785 1:CAS:528:DC%2BD2sXlt1Oktb8%3D 17327385 (Pubitemid 46997196)
7. R Sladek G Rocheleau J Rung, et al. 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885 10.1038/nature05616 1:CAS:528:DC%2BD2sXhvFGiurw%3D 17293876 (Pubitemid 46309843)
8. E Zeggini MN Weedon CM Lindgren, et al. 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341 10.1126/science.1142364 1:CAS:528:DC%2BD2sXmtVymtb0%3D 17463249 (Pubitemid 46871654)
9. R Saxena BF Voight V Lyssenko, et al. 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 10.1126/science.1142358 1:CAS:528:DC%2BD2sXmtVyitrk%3D 17463246 (Pubitemid 46871653)
10. H Unoki A Takahashi T Kawaguchi, et al. 2008 SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations Nat Genet 40 1098 1102 10.1038/ng.208 1:CAS:528:DC%2BD1cXhtVGgt77E 18711366
11. K Yasuda K Miyake Y Horikawa, et al. 2008 Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat Genet 40 1092 1097 10.1038/ng.207 1:CAS:528:DC%2BD1cXhtVGgt77M 18711367
12. JB McAteer S Prudente S Bacci, et al. 2008 The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42, 042 subjects Diabetes 57 1125 1130 10.2337/db07-1336 1:CAS:528:DC%2BD1cXksVGrsrg%3D 18071025
13. BA Maddux ID Goldfine 2000 Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit Diabetes 49 13 19 10.2337/diabetes.49.1.13 1:CAS:528: DC%2BD3cXkt1yhsg%3D%3D 10615944
14. BV Costanzo V Trischitta R Di Paola, et al. 2001 The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121) Diabetes 50 831 836 10.2337/diabetes.50.4.831 1:CAS:528: DC%2BD3MXisFOjtLw%3D 11289049
15. A Kubaszek J Pihlajamaki P Karhapaa I Vauhkonen M Laakso 2003 The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia Diabetes Care 26 464 467 10.2337/diacare.26.2.464 1:CAS:528:DC%2BD3sXhs1ynu7o%3D 12547881 (Pubitemid 36929074)
16. A Pizzuti L Frittitta A Argiolas, et al. 1999 A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance Diabetes 48 1881 1884 10.2337/diabetes.48.9.1881 1:CAS:528:DyaK1MXmtVaiur8%3D 10480624 (Pubitemid 29415213)
17. N Abate L Carulli A Cabo-Chan Jr M Chandalia PG Snell SM Grundy 2003 Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance J Clin Endocrinol Metab 88 5927 5934 10.1210/jc.2003-030453 1:CAS:528: DC%2BD3sXhtVSgsrvP 14671192 (Pubitemid 38033074)
18. N Abate M Chandalia P Satija, et al. 2005 ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes Diabetes 54 1207 1213 10.2337/diabetes.54.4.1207 1:CAS:528:DC%2BD2MXjtFWnur0%3D 15793263 (Pubitemid 40446338)
19. HF Gu P Almgren E Lindholm, et al. 2000 Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis Diabetes 49 1601 1603 10.2337/diabetes.49.9.1601 1:CAS:528:DC%2BD3cXmsVOrtro%3D 10969847
20. A Kubaszek A Markkanen JG Eriksson, et al. 2004 The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth J Clin Endocrinol Metab 89 2044 2047 10.1210/jc.2003-031350 1:CAS:528:DC%2BD2cXjvFyrsLc%3D 15126519 (Pubitemid 38619831)
21. D Meyre N Bouatia-Naji A Tounian, et al. 2005 Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes Nat Genet 37 863 867 10.1038/ng1604 1:CAS:528:DC%2BD2MXmsFKls74%3D 16025115 (Pubitemid 41077112)
22. N Grarup SA Urhammer J Ek, et al. 2006 Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7, 333 Danish white subjects Diabetologia 49 2097 2104 10.1007/s00125-006-0353-x 1:CAS:528:DC%2BD28XnslSiu78%3D 16865358 (Pubitemid 44168477)
23. AF Moore KA Jablonski CC Mason, et al. 2009 The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program J Clin Endocrinol Metab 94 449 455 10.1210/jc.2008-1583 1:CAS:528:DC%2BD1MXhvFCqsLs%3D 19017751
24. SK Rasmussen SA Urhammer A Pizzuti, et al. 2000 The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians Diabetes 49 1608 1611 10.2337/diabetes.49.9.1608 1:CAS:528:DC%2BD3cXmsVOrtrg%3D 10969849
25. MN Weedon B Shields G Hitman, et al. 2006 No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8, 089 U.K. Caucasians Diabetes 55 3175 3179 10.2337/db06-0410 1:CAS:528: DC%2BD28XhtF2rtr%2FE 17065358 (Pubitemid 44923658)
26. HN Lyon JC Florez T Bersaglieri, et al. 2006 Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity Diabetes 55 3180 3184 10.2337/db06-0407 1:CAS:528:DC%2BD28XhtF2rtr%2FF 17065359 (Pubitemid 44923659)
27. N Stefan F Machicao H Staiger, et al. 2005 Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat Diabetologia 48 2282 2291 10.1007/s00125-005-1948-3 1:CAS:528:DC%2BD2MXht1Skt7vI 16205883 (Pubitemid 41618919)
28. J Tuomilehto J Lindstrom JG Eriksson, et al. 2001 Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance N Engl J Med 344 1343 1350 10.1056/NEJM200105033441801 1:STN:280:DC%2BD3M3kvFejsA%3D%3D 11333990 (Pubitemid 32378388)
29. S Schäfer K Kantartzis J Machann, et al. 2007 Lifestyle intervention in individuals with normal versus impaired glucose tolerance Eur J Clin Invest 37 535 543 10.1111/j.1365-2362.2007.01820.x 17576204 (Pubitemid 46920190)
30. M Matsuda RA DeFronzo 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 22 1462 1470 10.2337/diacare.22.9.1462 1:STN:280: DyaK1MvgvVertQ%3D%3D 10480510 (Pubitemid 29418240)
31. X Ma D Becker VC Arena P Vicini C Greenbaum 2009 The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysis J Clin Endocrinol Metab 94 2446 2451 10.1210/jc.2008-2687 1:CAS:528:DC%2BD1MXosl2ks74%3D 19401372
32. U Masharani ID Goldfine JF Youngren 2009 Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects Metabolism 58 1602 1608 10.1016/j.metabol.2009.05.012 1:CAS:528:DC%2BD1MXht1OnsrjM 19604524
33. R Baratta R Di Paola D Spampinato, et al. 2003 Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms J Mol Med 81 718 723 10.1007/s00109-003-0466-3 1:CAS:528:DC%2BD3sXovVOgsbo%3D 14574455 (Pubitemid 37491597)