The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: A population analysis

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 7, 2009, Pages 2446-2451

  Ma, Xiaosu ^a   Becker, Dorothy ^b   Arena, Vincent C ^c   Vicini, Paolo ^a,e   Greenbaum, Carla ^d  

^a University of Washington   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d BENAROYA RESEARCH INSTITUTE   (United States)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUCOSE; INSULIN;

ADOLESCENT; ADULT; ADULTHOOD; AGE DISTRIBUTION; AGED; ARTICLE; CELL FUNCTION; CHILD; CLINICAL ASSESSMENT; CROSS-SECTIONAL STUDY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GROUPS BY AGE; HEREDITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KINETICS; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; POPULATION BASED CASE CONTROL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RELATIVE; SCHOOL CHILD; UNIVERSITY HOSPITAL;

EID: 67650227510     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2687     Document Type: Article

References (33)

1. Achenbach P, Bonifacio E, Koczwara K, Ziegler AG 2005 Natural history of type 1 diabetes. Diabetes 54(Suppl 2):S25-S31
2. Haller MJ, Atkinson MA, Schatz D 2005 Type 1 diabetes mellitus: etiology, presentation, and management. Pediatr Clin North Am 52:1553-1578
3. Kimpimäki T, Kulmala P, Savola K, Vähäsalo P, Reijonen H, Ilonen J, Akerblom HK, Knip M 2000 Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group. J Clin Endocrinol Metab 85:1126-1132
4. Eisenbarth GS, Gianani R, Yu L, Pietropaolo M, Verge CF, Chase HP, Redondo MJ, Colman P, Harrison L, Jackson R 1998 Dual-parameter model for prediction of type I diabetes mellitus. Proc Assoc Am Physicians 110:126-135
5. Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte M, Bottazzo GF, Gale EA 1994 Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody positive relatives. Diabetes 43:1304-1310
6. Sosenko JM, Palmer JP, Greenbaum CJ, Mahon J, Cowie C, Krischer JP, Chase HP, White NH, Buckingham B, Herold KC, Cuthbertson D, Skyler JS 2006 Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 29:643-649
7. Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC 2004 Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia 47:1661-1667
8. Xu P, Cuthbertson D, Greenbaum C, Palmer JP, Krischer JP 2007 Role of insulin resistance in predicting progression to type 1 diabetes. Diabetes Care 30:2314-2320
9. Bingley PJ, Mahon JL, Gale EA 2008 Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care 31:146-150
10. Pilcher CC, Elliott RB 1990 A sensitive and reproducible method for the assay of human islet cell antibodies. J Immunol Methods 129:111-117
11. Pietropaolo M, Becker DJ, LaPorte RE, Dorman JS, Riboni S, Rudert WA, Mazumdar S, Trucco M 2002 Progression to insulin-requiring diabetes in seronegative prediabetic subjects. the role of two HLA-DQ high risk haplotype2. Diabetologia 45:66-76
12. Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, Karlsen AE, Boel E, Michelsen B, Lernmark A 1994 A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37:344-350
13. Pietropaolo M, Peakman M, Pietropaolo SL, Zanone MM, Foley Jr TP, Becker DJ, Trucco M 1998 Combined analysis of GAD65 and ICA512 (IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus. J Autoimmun 11:1-10
14. Dalla Man C, Caumo A, Cobelli C 2002 The oral glucose minimal model: estimation of insulin sensitivity from a meal test. IEEE Trans Biomed Eng 49:419-429
15. Dalla Man C, Caumo A, Basu R, Rizza R, Toffolo G, Cobelli C 2004 Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method. Am J Physiol Endocrinol Metab 287:E637-E643
16. Phillips DI, Clark PM, Hales CN, Osmond C 1994 Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med 11:286-292
17. Dalla Man C, Yarasheski KE, Caumo A, Robertson H, Toffolo G, Polonsky KS, Cobelli C 2005 Insulin sensitivity by oral glucose minimal models: validation against clamp. Am J Physiol Endocrinol Metab 289:E954-E959
18. Stumvoll M, Tataranni PA, Bogardus C 2005 The hyperbolic law - a 25-year perspective. Diabetologia 48:207-209
19. Basu R, Breda E, Oberg AL, Powell CC, Dalla Man C, Basu A, Vittone JL, Klee GG, Arora P, Jensen MD, Toffolo G, Cobelli C, Rizza RA 2003 Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes 52:1738-1748
20. Basu R, Dalla Man C, Campioni M, Basu A, Klee G, Toffolo G, Cobelli C, Rizza RA 2006 Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction. Diabetes 55:2001-2014
21. Pacini G, Beccaro F, Valerio A, Nosadini R, Crepaldi G 1990 Reduced β-cell secretion and insulin hepatic extraction in healthy elderly subjects. J Am Geriatr Soc 38:1283-1289
22. Hannon TS, Janosky J, Arslanian SA 2006 Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Pediatr Res 60:759-763
23. Fritsche A, Madaus A, Stefan N, Tschritter O, Maerker E, Teigeler A, Haring H, Stumvoll M 2002 Relationships among age, proinsulin conversion, and β-cell function in nondiabetic humans. Diabetes 51(Suppl 1):S234-S239
24. Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E 2005 Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial-Type 1. Diabetes Care 28:1068-1076
25. Diabetes Prevention Trial Study Group 2002 Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346:1685-1691
26. Goran MI, Gower BA 2001 Longitudinal study on pubertal insulin resistance. Diabetes 50:2444-2450
27. Ball GD, Huang TT, Gower BA, Cruz ML, Shaibi GQ, Weigensberg MJ, Goran MI 2006 Longitudinal changes in insulin sensitivity, insulin secretion, and β-cell function during puberty. J Pediatr 148:16-22
28. Leslie RD, Taylor R, Pozzilli P 1997 The role of insulin resistance in the natural history of type 1 diabetes. Diabet Med 14:327-331
29. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M 1989 A comparison of childhood and adult type I diabetes mellitus. N Engl J Med 320:881-886
30. Beyan H, Ola T, David R, Leslie G 2006 Progression of autoimmune diabetes: slowly progressive insulin-dependent diabetes mellitus or latent autoimmune diabetes of adult. Ann NY Acad Sci 1079:81-89
31. Greenbaum CJ 2002 Insulin resistance in type 1 diabetes. Diabetes Metab Res Rev 18:192-200
32. Chiu KC, Lee NP, Cohan P, Chuang LM 2000 β-Cell function declines with age in glucose tolerant Caucasians. Clin Endocrinol (Oxf) 53:569-575
33. Chiu KC, Martinez DS, Chu A 2005 Comparison of the relationship of age and β cell function in three ethnic groups. Clin Endocrinol (Oxf) 62:296-302