Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist

European Journal of Pharmacology

Volumn 135, Issue 2, 1987, Pages 193-201

  Hall, Ronald A ^a   Gillard, John ^a   Guindon, Yvan ^a   Letts, Gordon ^a   Champion, Eric ^a   Ethier, Diane ^a   Evans, Jillian ^a   Ford Hutchinson, Anthony W ^a   Fortin, Réjean ^a   Jones, Thomas R ^a   Lord, Anne ^a   Morton, Howard E ^a   Rokach, Joshua ^a   Yoakim, Christiane ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Platelet aggregation; Prostaglandin endoperoxides; Thromboxane A2; Thromboxane antagonist

Indexed keywords

15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 [1 (4 CHLOROBENZYL) 5 FLUORO 3 METHYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ACETYLCHOLINE; HISTAMINE; INDOMETACIN; LEUKOTRIENE D4; PROSTAGLANDIN D2; PROSTAGLANDIN ENDOPEROXIDE; PROSTAGLANDIN F2 ALPHA; SEROTONIN; THROMBOXANE A2;

ANIMAL CELL; AORTA; BLOOD AND HEMOPOIETIC SYSTEM; GREAT BLOOD VESSEL; GUINEA PIG; HUMAN; LUNG ARTERY; MONKEY; MUSCLE; NONHUMAN; PHARMACOLOGY; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SMOOTH MUSCLE CONTRACTILITY; THROMBOCYTE AGGREGATION; TRACHEA;

ANIMALS; GUINEA PIGS; HUMANS; INDOLES; MACACA MULATTA; MALE; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; PLATELET AGGREGATION; PROSTAGLANDIN ENDOPEROXIDES; THROMBOXANES;

EID: 0023129137     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(87)90611-X     Document Type: Article

References (18)

1. The physiologic and pharmacologic characteristics of the tracheal muscle
2. Prostaglandin endoperoxide analogues which are both thromboxane receptors antagonists and prostacyclin mimetics
3. Some quantitative uses of drug antagonists
4. 2
5. 2
6. Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung
7. Inhibition of prostanoid-mediated platelet aggregation in vivo and in vitro by 3-hydroxymethyl-dibenzo (b,f)thiepin 5,5-dioxide (L-640,035)
8. 2-mediated bronchoconstriction in the anesthetized guinea-pig
9. Thromboxane receptor antagonist properties of SQ 27,427 in the anesthetized guinea-pig
10. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides
11. Antagonism of the thromboxane-sensitive contractile systems of the rabbit aorta, dog saphenous vein and guinea-pig trachea
12. Studies on the characterisation of prostanoid receptors: a proposed classification
13. 2 receptors in platelets and blood vessels: evidence for different receptors
14. Human arterial and venous tissue generate prostacyclin (prostaglandin X) a potent inhibitor of platelet aggregation
15. 2 and prostacyclin
16. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist
17. Investigations on a selective non-prostanoic thromboxane anatagonist, BM 13.177, in muman platelets
18. 2 in vitro