Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function

British Journal of Pharmacology

Volumn 138, Issue 3, 2003, Pages 435-444

  Altmann, Christoph ^a   Meyer Zu Heringdorf, Dagmar ^a   Böyükbas, Dilek ^a   Haude, Michael ^a   Jakobs, Karl H ^a   Michel, Martin C ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Phospholipase C; Platelet activation; Protein kinase A; Protein kinase C; Sphingosylphosphorylcholine

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CALCIUM ION; CD63 ANTIGEN; CELL SURFACE RECEPTOR; COLLAGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEXTRO ERYTHRO SPHINGOSYLPHOSPHORYLCHOLINE; FIBRINOGEN; FIBRINOGEN RECEPTOR; LIPID; NATURAL PRODUCT; PADGEM PROTEIN; PROTEIN PAC 1; SPHINGOSYLPHOSPHORYLCHOLINE; THREO SPHINGOSYLPHOSPHORYLCHOLINE; THROMBIN RECEPTOR ACTIVATING PEPTIDE; THROMBOXANE A2; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STEREOISOMERISM; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE MEMBRANE;

BLOOD PLATELETS; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; PHOSPHOLIPASE C; PHOSPHORYLCHOLINE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASE C; SPHINGOSINE; TIME FACTORS;

EID: 0037331175     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705063     Document Type: Article

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