New tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1381-1386

  Cimetière, Bernard ^a   Dubuffet, Thierry ^a   Landras, Caroline ^a   Descombes, Jean Jacques ^a   Simonet, Serge ^a   Verbeuren, Tony J ^a   Lavielle, Gilbert ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; PROSTAGLANDIN H2; TETRALIN DERIVATIVE; THROMBOXANE A2; THROMBOXANE RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA PROTEIN BINDING; RABBIT; RAT; RECEPTOR BLOCKING; SAPHENOUS VEIN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ENZYME INHIBITORS; GUINEA PIGS; HUMANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PLATELET AGGREGATION INHIBITORS; PRESSURE; RABBITS; RECEPTORS, THROMBOXANE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TETRAHYDRONAPHTHALENES; THROMBOXANE-A SYNTHASE; TRACHEA;

EID: 0032474559     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00221-2     Document Type: Article

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