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Volumn 13, Issue 1, 2009, Pages 194-203

Kruppel like factor 4 (KLF4): A transcription factor with diverse context-dependent functions

Author keywords

Induced pluripotent stem cells (iPS cells); KLF4; Notch signaling; Oncogene; Tumor suppressor

Indexed keywords

IPS;

EID: 77649323253     PISSN: 15299120     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (122)
  • 1
    • 0034532401 scopus 로고    scopus 로고
    • Positiveand negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo
    • Adam PJ, Regan CP, Hautmann MB, and Owens GK (2000) Positiveand negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. J Biol Chem. 275, 37798-37806
    • (2000) J Biol Chem , vol.275 , pp. 37798-37806
    • Adam, P.J.1    Regan, C.P.2    Hautmann, M.B.3    Owens, G.K.4
  • 3
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, and Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science. 284, 770-776
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 4
    • 2442692762 scopus 로고    scopus 로고
    • Stem cell bioengineering for regenerative medicine
    • Audet J (2004) Stem cell bioengineering for regenerative medicine. Expert Opin Biol Ther. 4, 631-644
    • (2004) Expert Opin Biol Ther , vol.4 , pp. 631-644
    • Audet, J.1
  • 5
    • 0037376416 scopus 로고    scopus 로고
    • An overview of the Notch signalling pathway
    • Baron M (2003) An overview of the Notch signalling pathway. Semin Cell Dev Biol. 14, 113-119
    • (2003) Semin Cell Dev Biol , vol.14 , pp. 113-119
    • Baron, M.1
  • 6
    • 0036272521 scopus 로고    scopus 로고
    • Developmental and cell typespecific expression of the zinc finger transcription factor Kruppel-like factor 4 (Klf4) in postnatal mouse testis
    • Behr R, and Kaestner KH (2002) Developmental and cell typespecific expression of the zinc finger transcription factor Kruppel-like factor 4 (Klf4) in postnatal mouse testis. Mech Dev. 115, 167-169
    • (2002) Mech Dev , vol.115 , pp. 167-169
    • Behr, R.1    Kaestner, K.H.2
  • 8
    • 0035860820 scopus 로고    scopus 로고
    • Kruppel-like factors: three fingers in many pies
    • Bieker JJ (2001) Kruppel-like factors: three fingers in many pies. J Biol Chem. 276, 34355-34358
    • (2001) J Biol Chem , vol.276 , pp. 34355-34358
    • Bieker, J.J.1
  • 9
    • 0034623068 scopus 로고    scopus 로고
    • The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1
    • Brembeck FH, and Rustgi AK (2000) The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1. J Biol Chem. 275, 28230-28239
    • (2000) J Biol Chem , vol.275 , pp. 28230-28239
    • Brembeck, F.H.1    Rustgi, A.K.2
  • 12
    • 0035839554 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (gutenriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle
    • Chen X, Johns DC, Geiman DE, Marban E, Dang DT, Hamlin G, Sun R, and Yang VW (2001a) Kruppel-like factor 4 (gutenriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J Biol Chem. 276, 30423-30428
    • (2001) J Biol Chem , vol.276 , pp. 30423-30428
    • Chen, X.1    Johns, D.C.2    Geiman, D.E.3    Marban, E.4    Dang, D.T.5    Hamlin, G.6    Sun, R.7    Yang, V.W.8
  • 13
    • 0037607309 scopus 로고    scopus 로고
    • [Effect of ginsenosides in inducing proliferation and transcription factor of erythrocytic, granulo-monocytic and megakarocytic cell lines]
    • Chen XH, Gao RL, and Xu WH (2001b) [Effect of ginsenosides in inducing proliferation and transcription factor of erythrocytic, granulo-monocytic and megakarocytic cell lines]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 21, 40-42
    • (2001) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.21 , pp. 40-42
    • Chen, X.H.1    Gao, R.L.2    Xu, W.H.3
  • 14
    • 63549141307 scopus 로고    scopus 로고
    • Spatial and temporal expression of KLF4 and KLF5 during murine tooth development
    • Chen Z, Couble ML, Mouterfi N, Magloire H, and Bleicher F (2009) Spatial and temporal expression of KLF4 and KLF5 during murine tooth development. Arch Oral Biol. 54, 403-411
    • (2009) Arch Oral Biol , vol.54 , pp. 403-411
    • Chen, Z.1    Couble, M.L.2    Mouterfi, N.3    Magloire, H.4    Bleicher, F.5
  • 15
    • 1842582972 scopus 로고    scopus 로고
    • Kruppel-like factor 4 is transactivated by butyrate in colon cancer cells
    • Chen ZY, Rex S, and Tseng CC (2004) Kruppel-like factor 4 is transactivated by butyrate in colon cancer cells. J Nutr. 134, 792-798
    • (2004) J Nutr , vol.134 , pp. 792-798
    • Chen, Z.Y.1    Rex, S.2    Tseng, C.C.3
  • 16
    • 0037195422 scopus 로고    scopus 로고
    • Gut-enriched Kruppellike factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells
    • Chen ZY, Shie JL, and Tseng CC (2002) Gut-enriched Kruppellike factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells. J Biol Chem. 277, 46831-46839
    • (2002) J Biol Chem , vol.277 , pp. 46831-46839
    • Chen, Z.Y.1    Shie, J.L.2    Tseng, C.C.3
  • 17
    • 16644366016 scopus 로고    scopus 로고
    • Cell and tissue specific expression of human Kruppel-like transcription factors in human ocular surface
    • Chiambaretta F, De Graeve F, Turet G, Marceau G, Gain P, Dastugue B, Rigal D, and Sapin V (2004) Cell and tissue specific expression of human Kruppel-like transcription factors in human ocular surface. Mol Vis. 10, 901-909
    • (2004) Mol Vis , vol.10 , pp. 901-909
    • Chiambaretta, F.1    De Graeve, F.2    Turet, G.3    Marceau, G.4    Gain, P.5    Dastugue, B.6    Rigal, D.7    Sapin, V.8
  • 19
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    • Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, and Ma X (2007) Interleukin10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity. 27, 952-964
    • (2007) Immunity , vol.27 , pp. 952-964
    • Chung, E.Y.1    Liu, J.2    Homma, Y.3    Zhang, Y.4    Brendolan, A.5    Saggese, M.6    Han, J.7    Silverstein, R.8    Selleri, L.9    Ma, X.10
  • 20
    • 0141687002 scopus 로고    scopus 로고
    • Stemness, fusion and renewal of hematopoietic and embryonic stem cells
    • Constantinescu S (2003) Stemness, fusion and renewal of hematopoietic and embryonic stem cells. J Cell Mol Med. 7, 103-112
    • (2003) J Cell Mol Med , vol.7 , pp. 103-112
    • Constantinescu, S.1
  • 21
    • 43549107895 scopus 로고    scopus 로고
    • Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines
    • Cullingford TE, Butler MJ, Marshall AK, Tham el L, Sugden PH, and Clerk A (2008) Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochim Biophys Acta. 1783, 1229-1236
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 1229-1236
    • Cullingford, T.E.1    Butler, M.J.2    Marshall, A.K.3    Tham el, L.4    Sugden, P.H.5    Clerk, A.6
  • 22
    • 0034617495 scopus 로고    scopus 로고
    • Decreased expression of the gutenriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients
    • Dang DT, Bachman KE, Mahatan CS, Dang LH, Giardiello FM, and Yang VW (2000a) Decreased expression of the gutenriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. FEBS Lett. 476, 203-207
    • (2000) FEBS Lett , vol.476 , pp. 203-207
    • Dang, D.T.1    Bachman, K.E.2    Mahatan, C.S.3    Dang, L.H.4    Giardiello, F.M.5    Yang, V.W.6
  • 23
    • 0037780740 scopus 로고    scopus 로고
    • Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    • Dang DT, Chen X, Feng J, Torbenson M, Dang LH, and Yang VW (2003) Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene. 22, 3424-3430
    • (2003) Oncogene , vol.22 , pp. 3424-3430
    • Dang, D.T.1    Chen, X.2    Feng, J.3    Torbenson, M.4    Dang, L.H.5    Yang, V.W.6
  • 24
    • 0034532675 scopus 로고    scopus 로고
    • The biology of the mammalian Kruppel-like family of transcription factors
    • Dang DT, Pevsner J, and Yang VW (2000b) The biology of the mammalian Kruppel-like family of transcription factors. Int J Biochem Cell Biol. 32, 1103-1121
    • (2000) Int J Biochem Cell Biol , vol.32 , pp. 1103-1121
    • Dang, D.T.1    Pevsner, J.2    Yang, V.W.3
  • 27
    • 47549096256 scopus 로고    scopus 로고
    • Roles of Krupel-like factor 4 in normal homeostasis, cancer and stem cells
    • Evans PM, and Liu C (2008) Roles of Krupel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin (Shanghai). 40, 554-564
    • (2008) Acta Biochim Biophys Sin (Shanghai) , vol.40 , pp. 554-564
    • Evans, P.M.1    Liu, C.2
  • 30
    • 56249119515 scopus 로고    scopus 로고
    • KLF4 regulation in intestinal epithelial cell maturation
    • Flandez M, Guilmeau S, Blache P, and Augenlicht LH (2008) KLF4 regulation in intestinal epithelial cell maturation. Exp Cell Res. 314, 3712-3723
    • (2008) Exp Cell Res , vol.314 , pp. 3712-3723
    • Flandez, M.1    Guilmeau, S.2    Blache, P.3    Augenlicht, L.H.4
  • 32
    • 0033057439 scopus 로고    scopus 로고
    • Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF
    • Foster KW, Ren S, Louro ID, Lobo-Ruppert SM, McKie-Bell P, Grizzle W, Hayes MR, Broker TR, Chow LT, and Ruppert JM (1999) Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF. Cell Growth Differ. 10, 423-434
    • (1999) Cell Growth Differ , vol.10 , pp. 423-434
    • Foster, K.W.1    Ren, S.2    Louro, I.D.3    Lobo-Ruppert, S.M.4    McKie-Bell, P.5    Grizzle, W.6    Hayes, M.R.7    Broker, T.R.8    Chow, L.T.9    Ruppert, J.M.10
  • 34
    • 0029969727 scopus 로고    scopus 로고
    • A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
    • Garrett-Sinha LA, Eberspaecher H, Seldin MF, and de Crombrugghe B (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem. 271, 31384-31390
    • (1996) J Biol Chem , vol.271 , pp. 31384-31390
    • Garrett-Sinha, L.A.1    Eberspaecher, H.2    Seldin, M.F.3    de Crombrugghe, B.4
  • 35
    • 0034160164 scopus 로고    scopus 로고
    • Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction
    • Geiman DE, Ton-That H, Johnson JM, and Yang VW (2000) Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res. 28, 1106-1113
    • (2000) Nucleic Acids Res , vol.28 , pp. 1106-1113
    • Geiman, D.E.1    Ton-That, H.2    Johnson, J.M.3    Yang, V.W.4
  • 36
    • 57749110620 scopus 로고    scopus 로고
    • Notch inhibits expression of the Kruppellike factor 4 tumor suppressor in the intestinal epithelium
    • Ghaleb AM, Aggarwal G, Bialkowska AB, Nandan MO, and Yang VW (2008) Notch inhibits expression of the Kruppellike factor 4 tumor suppressor in the intestinal epithelium. Mol Cancer Res. 6, 1920-1927
    • (2008) Mol Cancer Res , vol.6 , pp. 1920-1927
    • Ghaleb, A.M.1    Aggarwal, G.2    Bialkowska, A.B.3    Nandan, M.O.4    Yang, V.W.5
  • 37
    • 34147108779 scopus 로고    scopus 로고
    • Kruppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage
    • Ghaleb AM, Katz JP, Kaestner KH, Du JX, and Yang VW (2007) Kruppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. Oncogene. 26, 2365-2373
    • (2007) Oncogene , vol.26 , pp. 2365-2373
    • Ghaleb, A.M.1    Katz, J.P.2    Kaestner, K.H.3    Du, J.X.4    Yang, V.W.5
  • 38
  • 39
    • 27144463658 scopus 로고    scopus 로고
    • The mouse Kruppel-like Factor 4 (Klf4) gene: four functional polyadenylation sites which are used in a cell-specific manner as revealed by testicular transcript analysis and multiple processed pseudogenes
    • Godmann M, Kromberg I, Mayer J, and Behr R (2005) The mouse Kruppel-like Factor 4 (Klf4) gene: four functional polyadenylation sites which are used in a cell-specific manner as revealed by testicular transcript analysis and multiple processed pseudogenes. Gene. 361, 149-156
    • (2005) Gene , vol.361 , pp. 149-156
    • Godmann, M.1    Kromberg, I.2    Mayer, J.3    Behr, R.4
  • 40
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu Y, Turck CW, and Morgan DO (1993) Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 366, 707-710
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 41
    • 1642433000 scopus 로고    scopus 로고
    • Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation
    • Hansen D, Wilson-Berry L, Dang T, and Schedl T (2004) Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development. 131, 93-104
    • (2004) Development , vol.131 , pp. 93-104
    • Hansen, D.1    Wilson-Berry, L.2    Dang, T.3    Schedl, T.4
  • 42
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K, and Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75, 805-816
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 43
    • 0031240003 scopus 로고    scopus 로고
    • Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina
    • Henrique D, Hirsinger E, Adam J, Le Roux I, Pourquie O, IshHorowicz D, and Lewis J (1997) Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr Biol. 7, 661-670
    • (1997) Curr Biol , vol.7 , pp. 661-670
    • Henrique, D.1    Hirsinger, E.2    Adam, J.3    Le Roux, I.4    Pourquie, O.5    IshHorowicz, D.6    Lewis, J.7
  • 44
    • 0036606463 scopus 로고    scopus 로고
    • Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1
    • Higaki Y, Schullery D, Kawata Y, Shnyreva M, Abrass C, and Bomsztyk K (2002) Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Nucleic Acids Res. 30, 2270-2279
    • (2002) Nucleic Acids Res , vol.30 , pp. 2270-2279
    • Higaki, Y.1    Schullery, D.2    Kawata, Y.3    Shnyreva, M.4    Abrass, C.5    Bomsztyk, K.6
  • 47
    • 0037218919 scopus 로고    scopus 로고
    • Sp1and Kruppellike transcription factors
    • Kaczynski J, Cook T, and Urrutia R (2003) Sp1and Kruppellike transcription factors. Genome Biol. 4, 206
    • (2003) Genome Biol , vol.4 , pp. 206
    • Kaczynski, J.1    Cook, T.2    Urrutia, R.3
  • 48
    • 64749111225 scopus 로고    scopus 로고
    • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    • Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, and Woltjen K (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458, 771-775
    • (2009) Nature , vol.458 , pp. 771-775
    • Kaji, K.1    Norrby, K.2    Paca, A.3    Mileikovsky, M.4    Mohseni, P.5    Woltjen, K.6
  • 50
    • 0036340041 scopus 로고    scopus 로고
    • The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    • Katz JP, Perreault N, Goldstein BG, Lee CS, Labosky PA, Yang VW, and Kaestner KH (2002) The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 129, 2619-2628
    • (2002) Development , vol.129 , pp. 2619-2628
    • Katz, J.P.1    Perreault, N.2    Goldstein, B.G.3    Lee, C.S.4    Labosky, P.A.5    Yang, V.W.6    Kaestner, K.H.7
  • 54
    • 11244281579 scopus 로고    scopus 로고
    • Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
    • Li Y, McClintick J, Zhong L, Edenberg HJ, Yoder MC, and Chan RJ (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood. 105, 635-637
    • (2005) Blood , vol.105 , pp. 635-637
    • Li Y1    McClintick, J.2    Zhong, L.3    Edenberg, H.J.4    Yoder, M.C.5    Chan, R.J.6
  • 55
    • 52649086692 scopus 로고    scopus 로고
    • KLF4 promotes the expression, translocation, and releas eof HMGB1 in RAW264.7 macrophages in response to LPS
    • Liu J, Liu Y, Zhang H, Chen G, Wang K, and Xiao X (2008a) KLF4 promotes the expression, translocation, and releas eof HMGB1 in RAW264.7 macrophages in response to LPS. Shock. 30, 260-266
    • (2008) Shock , vol.30 , pp. 260-266
    • Liu, J.1    Liu, Y.2    Zhang, H.3    Chen, G.4    Wang, K.5    Xiao, X.6
  • 57
    • 40349102090 scopus 로고    scopus 로고
    • Kruppellike factor 4 is a novel mediator of selenium in growth inhibition
    • Liu S, Zhang H, Zhu L, Zhao L, and Dong Y (2008b) Kruppellike factor 4 is a novel mediator of selenium in growth inhibition. Mol Cancer Res. 6, 306-313
    • (2008) Mol Cancer Res , vol.6 , pp. 306-313
    • Liu, S.1    Zhang, H.2    Zhu, L.3    Zhao, L.4    Dong, Y.5
  • 58
    • 15744367559 scopus 로고    scopus 로고
    • Kruppel-like factor 4 abrogates myocardininduced activation of smooth muscle gene expression
    • Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH, and Owens GK (2005) Kruppel-like factor 4 abrogates myocardininduced activation of smooth muscle gene expression. J Biol Chem. 280, 9719-9727
    • (2005) J Biol Chem , vol.280 , pp. 9719-9727
    • Liu, Y.1    Sinha, S.2    McDonald, O.G.3    Shang, Y.4    Hoofnagle, M.H.5    Owens, G.K.6
  • 59
    • 1442351994 scopus 로고    scopus 로고
    • Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray
    • Luo A, Kong J, Hu G, Liew CC, Xiong M, Wang X, Ji J, Wang T, Zhi H, Wu M, and Liu Z (2004) Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene. 23, 1291-1299
    • (2004) Oncogene , vol.23 , pp. 1291-1299
    • Luo, A.1    Kong, J.2    Hu, G.3    Liew, C.C.4    Xiong, M.5    Wang, X.6    Ji, J.7    Wang, T.8    Zhi, H.9    Wu, M.10    Liu, Z.11
  • 60
    • 0037093815 scopus 로고    scopus 로고
    • Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis
    • Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, and Isaacs W (2002) Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis. Prostate. 51, 189-200
    • (2002) Prostate , vol.51 , pp. 189-200
    • Luo, J.1    Dunn, T.2    Ewing, C.3    Sauvageot, J.4    Chen, Y.5    Trent, J.6    Isaacs, W.7
  • 63
    • 0028988159 scopus 로고
    • p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
    • Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, and Elledge SJ (1995) p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9, 650-662
    • (1995) Genes Dev , vol.9 , pp. 650-662
    • Matsuoka, S.1    Edwards, M.C.2    Bai, C.3    Parker, S.4    Zhang, P.5    Baldini, A.6    Harper, J.W.7    Elledge, S.J.8
  • 64
    • 34250216304 scopus 로고    scopus 로고
    • The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology
    • McConnell BB, Ghaleb AM, Nandan MO, and Yang VW (2007) The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays. 29, 549-557
    • (2007) Bioessays , vol.29 , pp. 549-557
    • McConnell, B.B.1    Ghaleb, A.M.2    Nandan, M.O.3    Yang, V.W.4
  • 67
  • 69
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser AR, Pitot HC, and Dove WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science. 247, 322-324
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 71
    • 34648814084 scopus 로고    scopus 로고
    • Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision
    • Nakamura T, Tsuchiya K, and Watanabe M (2007) Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J Gastroenterol. 42, 705-710
    • (2007) J Gastroenterol , vol.42 , pp. 705-710
    • Nakamura, T.1    Tsuchiya, K.2    Watanabe, M.3
  • 73
    • 2442686555 scopus 로고    scopus 로고
    • Kruppel-like factor 5 mediates the transforming activity of oncogenic H-Ras
    • Nandan MO, Yoon HS, Zhao W, Ouko LA, Chanchevalap S, and Yang VW (2004) Kruppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene. 23, 3404-3413
    • (2004) Oncogene , vol.23 , pp. 3404-3413
    • Nandan, M.O.1    Yoon, H.S.2    Zhao, W.3    Ouko, L.A.4    Chanchevalap, S.5    Yang, V.W.6
  • 74
    • 0032776157 scopus 로고    scopus 로고
    • The adenomatous polyposis coli protein
    • Nathke IS (1999) The adenomatous polyposis coli protein. Mol Pathol. 52, 169-173
    • (1999) Mol Pathol , vol.52 , pp. 169-173
    • Nathke, I.S.1
  • 76
    • 0034031381 scopus 로고    scopus 로고
    • Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5
    • Ohnishi S, Laub F, Matsumoto N, Asaka M, Ramirez F, Yoshida T, and Terada M (2000) Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5. Dev Dyn. 217, 421-429
    • (2000) Dev Dyn , vol.217 , pp. 421-429
    • Ohnishi, S.1    Laub, F.2    Matsumoto, N.3    Asaka, M.4    Ramirez, F.5    Yoshida, T.6    Terada, M.7
  • 78
    • 0034603864 scopus 로고    scopus 로고
    • The Kruppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact
    • Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman SL, and Rustgi AK (2000) The Kruppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. FEBS Lett. 473, 95-100
    • (2000) FEBS Lett , vol.473 , pp. 95-100
    • Okano, J.1    Opitz, O.G.2    Nakagawa, H.3    Jenkins, T.D.4    Friedman, S.L.5    Rustgi, A.K.6
  • 79
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita K, Ichisaka T, and Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature. 448, 313-317
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 80
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors
    • Okita K, Nakagawa M, Hyenjong H, Ichisaka T, and Yamanaka S (2008) Generation of mouse induced pluripotent stem cells without viral vectors. Science. 322, 949-953
    • (2008) Science , vol.322 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 83
    • 0033178330 scopus 로고    scopus 로고
    • A tale of three fingers: the family of mammalian Sp/XKLF transcription factors
    • Philipsen S, and Suske G (1999) A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 27, 2991-3000
    • (1999) Nucleic Acids Res , vol.27 , pp. 2991-3000
    • Philipsen, S.1    Suske, G.2
  • 84
    • 30144440248 scopus 로고    scopus 로고
    • The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
    • Rowland BD, Bernards R, and Peeper DS (2005) The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol. 7, 1074-1082
    • (2005) Nat Cell Biol , vol.7 , pp. 1074-1082
    • Rowland, B.D.1    Bernards, R.2    Peeper, D.S.3
  • 85
    • 30144442965 scopus 로고    scopus 로고
    • KLF4, p21 and contextdependent opposing forces in cancer
    • Rowland BD, and Peeper DS (2006) KLF4, p21 and contextdependent opposing forces in cancer. Nat Rev Cancer. 6, 11-23
    • (2006) Nat Rev Cancer , vol.6 , pp. 11-23
    • Rowland, B.D.1    Peeper, D.S.2
  • 87
    • 0032813661 scopus 로고    scopus 로고
    • Klf4 is a transcription factor required for establishing the barrier function of the skin
    • Segre JA, Bauer C, and Fuchs E (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet. 22, 356-360
    • (1999) Nat Genet , vol.22 , pp. 356-360
    • Segre, J.A.1    Bauer, C.2    Fuchs, E.3
  • 88
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: positive and negative regulators of G1-phase progression
    • Sherr CJ, and Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 89
    • 0034238112 scopus 로고    scopus 로고
    • Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif
    • Shie JL, Chen ZY, Fu M, Pestell RG, and Tseng CC (2000a) Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res. 28, 2969-2976
    • (2000) Nucleic Acids Res , vol.28 , pp. 2969-2976
    • Shie, J.L.1    Chen, Z.Y.2    Fu, M.3    Pestell, R.G.4    Tseng, C.C.5
  • 91
    • 0029829236 scopus 로고    scopus 로고
    • Identification and characterization of a gene encoding a gut-enriched Kruppellike factor expressed during growth arrest
    • Shields JM, Christy RJ, and Yang VW (1996) Identification and characterization of a gene encoding a gut-enriched Kruppellike factor expressed during growth arrest. J Biol Chem. 271, 20009-20017
    • (1996) J Biol Chem , vol.271 , pp. 20009-20017
    • Shields, J.M.1    Christy, R.J.2    Yang, V.W.3
  • 92
    • 49049120141 scopus 로고    scopus 로고
    • Identification of candidate Klf4 target genes reveals themolecular basis of the diverse regulatory roles of Klf4 in the mouse cornea
    • Swamynathan SK, Davis J, and Piatigorsky J (2008) Identification of candidate Klf4 target genes reveals themolecular basis of the diverse regulatory roles of Klf4 in the mouse cornea. Invest Ophthalmol Vis Sci. 49, 3360-3370
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 3360-3370
    • Swamynathan, S.K.1    Davis, J.2    Piatigorsky, J.3
  • 93
    • 33845790551 scopus 로고    scopus 로고
    • Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
    • Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, and Piatigorsky J (2007) Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol. 27, 182-194
    • (2007) Mol Cell Biol , vol.27 , pp. 182-194
    • Swamynathan, S.K.1    Katz, J.P.2    Kaestner, K.H.3    Ashery-Padan, R.4    Crawford, M.A.5    Piatigorsky, J.6
  • 94
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, and Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 131, 861-872
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 95
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, and Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126, 663-676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 97
    • 0031451645 scopus 로고    scopus 로고
    • Expression of the gut-enriched Kruppel-like factor gene during development and intestinal tumorigenesis
    • Ton-That H, Kaestner KH, Shields JM, Mahatanankoon CS, and Yang VW (1997) Expression of the gut-enriched Kruppel-like factor gene during development and intestinal tumorigenesis. FEBS Lett. 419, 239-243
    • (1997) FEBS Lett , vol.419 , pp. 239-243
    • Ton-That, H.1    Kaestner, K.H.2    Shields, J.M.3    Mahatanankoon, C.S.4    Yang, V.W.5
  • 98
    • 0033137330 scopus 로고    scopus 로고
    • Mammalian Kruppel-like transcription factors: more than just a pretty finger
    • Turner J, and Crossley M (1999) Mammalian Kruppel-like transcription factors: more than just a pretty finger. Trends Biochem Sci. 24, 236-240
    • (1999) Trends Biochem Sci , vol.24 , pp. 236-240
    • Turner, J.1    Crossley, M.2
  • 99
    • 0034682037 scopus 로고    scopus 로고
    • Cell-cycle inhibitors: three families united by a common cause
    • Vidal A, and Koff A (2000) Cell-cycle inhibitors: three families united by a common cause. Gene. 247, 1-15
    • (2000) Gene , vol.247 , pp. 1-15
    • Vidal, A.1    Koff, A.2
  • 100
    • 0036901023 scopus 로고    scopus 로고
    • Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer
    • Wang N, Liu ZH, Ding F, Wang XQ, Zhou CN, and Wu M (2002) Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. World J Gastroenterol. 8, 966-970
    • (2002) World J Gastroenterol , vol.8 , pp. 966-970
    • Wang, N.1    Liu, Z.H.2    Ding, F.3    Wang, X.Q.4    Zhou, C.N.5    Wu, M.6
  • 101
    • 16844386207 scopus 로고    scopus 로고
    • Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression
    • Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S, and Xie K (2005) Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res. 65, 2746-2754
    • (2005) Cancer Res , vol.65 , pp. 2746-2754
    • Wei, D.1    Gong, W.2    Kanai, M.3    Schlunk, C.4    Wang, L.5    Yao, J.C.6    Wu, T.T.7    Huang, S.8    Xie, K.9
  • 102
    • 29844454865 scopus 로고    scopus 로고
    • Emerging role of KLF4 in human gastrointestinal cancer
    • Wei D, Kanai M, Huang S, and Xie K (2006) Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis. 27, 23-31
    • (2006) Carcinogenesis , vol.27 , pp. 23-31
    • Wei, D.1    Kanai, M.2    Huang, S.3    Xie, K.4
  • 103
    • 0021464779 scopus 로고
    • Kruppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation
    • Wieschaus E, Nusslein-Volhard C, and Kluding H (1984) Kruppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation. Dev Biol. 104, 172-186
    • (1984) Dev Biol , vol.104 , pp. 172-186
    • Wieschaus, E.1    Nusslein-Volhard, C.2    Kluding, H.3
  • 105
    • 44749090831 scopus 로고    scopus 로고
    • Dynamic down-regulation of Kruppel-like factor 4 in colorectal adenoma-carcinoma sequence
    • Xu J, Lu B, Xu F, Gu H, Fang Y, Huang Q, and Lai M (2008) Dynamic down-regulation of Kruppel-like factor 4 in colorectal adenoma-carcinoma sequence. J Cancer Res Clin Oncol. 134, 891-898
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 891-898
    • Xu, J.1    Lu, B.2    Xu, F.3    Gu, H.4    Fang, Y.5    Huang, Q.6    Lai, M.7
  • 106
    • 67349101678 scopus 로고    scopus 로고
    • Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2
    • Yamada T, Park CS, Mamonkin M, and Lacorazza HD (2009) Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2. Nat Immunol. 10, 618-626
    • (2009) Nat Immunol , vol.10 , pp. 618-626
    • Yamada, T.1    Park, C.S.2    Mamonkin, M.3    Lacorazza, H.D.4
  • 107
    • 37349040710 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors
    • Yamanaka S (2008) Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors. Cell Prolif. 41 Suppl 1, 51-56
    • (2008) Cell Prolif. 41 Suppl , vol.1 , pp. 51-56
    • Yamanaka, S.1
  • 108
    • 39049174827 scopus 로고    scopus 로고
    • A fresh look at iPS cells. Cell. 137, 13-17 Yamanaka S, and Takahashi K (2006) [Induction of pluripotent stem cells from mouse fibroblast cultures]
    • Yamanaka S (2009) A fresh look at iPS cells. Cell. 137, 13-17 Yamanaka S, and Takahashi K (2006) [Induction of pluripotent stem cells from mouse fibroblast cultures]. Tanpakushitsu Kakusan Koso. 51, 2346-2351
    • (2009) Tanpakushitsu Kakusan Koso , vol.51 , pp. 2346-2351
    • Yamanaka, S.1
  • 109
    • 40149101438 scopus 로고    scopus 로고
    • KLF4: a novel target for the treatment of atherosclerosis
    • Yan FF, Liu YF, Liu Y, and Zhao YX (2008) KLF4: a novel target for the treatment of atherosclerosis. Med Hypotheses. 70, 845-847
    • (2008) Med Hypotheses , vol.70 , pp. 845-847
    • Yan, F.F.1    Liu, Y.F.2    Liu, Y.3    Zhao, Y.X.4
  • 112
    • 0037462796 scopus 로고    scopus 로고
    • Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage
    • Yoon HS, Chen X, and Yang VW (2003) Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem. 278, 2101-2105
    • (2003) J Biol Chem , vol.278 , pp. 2101-2105
    • Yoon, H.S.1    Chen, X.2    Yang, V.W.3
  • 113
    • 1042301369 scopus 로고    scopus 로고
    • Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage
    • Yoon HS, and Yang VW (2004) Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem. 279, 5035-5041
    • (2004) J Biol Chem , vol.279 , pp. 5035-5041
    • Yoon, H.S.1    Yang, V.W.2
  • 117
    • 0034674712 scopus 로고    scopus 로고
    • The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
    • Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, Biggs JR, Kraft AS, and Yang VW (2000) The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem. 275, 18391-18398
    • (2000) J Biol Chem , vol.275 , pp. 18391-18398
    • Zhang, W.1    Geiman, D.E.2    Shields, J.M.3    Dang, D.T.4    Mahatan, C.S.5    Kaestner, K.H.6    Biggs, J.R.7    Kraft, A.S.8    Yang, V.W.9
  • 118
    • 0032503693 scopus 로고    scopus 로고
    • The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion
    • Zhang W, Shields JM, Sogawa K, Fujii-Kuriyama Y, and Yang VW (1998) The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. J Biol Chem. 273, 17917-17925
    • (1998) J Biol Chem , vol.273 , pp. 17917-17925
    • Zhang, W.1    Shields, J.M.2    Sogawa, K.3    Fujii-Kuriyama, Y.4    Yang, V.W.5
  • 119
    • 54949092372 scopus 로고    scopus 로고
    • From fibroblasts to iPS cells: induced pluripotency by defined factors
    • Zhao R, and Daley GQ (2008) From fibroblasts to iPS cells: induced pluripotency by defined factors. J Cell Biochem. 105, 949-955
    • (2008) J Cell Biochem , vol.105 , pp. 949-955
    • Zhao, R.1    Daley, G.Q.2
  • 120
    • 0842329848 scopus 로고    scopus 로고
    • Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
    • Zhao W, Hisamuddin IM, Nandan MO, Babbin BA, Lamb NE, and Yang VW (2004) Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene. 23, 395-402
    • (2004) Oncogene , vol.23 , pp. 395-402
    • Zhao, W.1    Hisamuddin, I.M.2    Nandan, M.O.3    Babbin, B.A.4    Lamb, N.E.5    Yang, V.W.6
  • 121
    • 65349189620 scopus 로고    scopus 로고
    • KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract
    • Zheng H, Pritchard DM, Yang X, Bennett E, Liu G, Liu C, and Ai W (2009) KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 296, G490-498
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Zheng, H.1    Pritchard, D.M.2    Yang, X.3    Bennett, E.4    Liu, G.5    Liu, C.6    Ai, W.7
  • 122
    • 58149302692 scopus 로고    scopus 로고
    • Glutamatergic stimulation triggers rapid Krupple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity
    • Zhu S, Tai C, MacVicar BA, Jia W, and Cynader MS (2009) Glutamatergic stimulation triggers rapid Krupple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity. Brain Res. 1250, 49-62
    • (2009) Brain Res , vol.1250 , pp. 49-62
    • Zhu, S.1    Tai, C.2    MacVicar, B.A.3    Jia, W.4    Cynader, M.S.5


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