Stemness, fusion and renewal of hematopoietic and embryonic stem cells

Journal of Cellular and Molecular Medicine

Volumn 7, Issue 2, 2003, Pages 103-112

  Constantinescu, Stefan ^a,b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

Author keywords

Hematopoietic reconstitution; Interleukin 3; LIF (Leukemia Inhibitory Factor); Multiploid cells; Nanog; Nuclear reprogramming; Oct4; Pluripotency; STAT3; Wnt

Indexed keywords

CYTOKINE; GROWTH FACTOR; HOMEODOMAIN PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCT4 PROTEIN; PROTEIN; PROTEIN NANOG; STAT3 PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ADOPTIVE IMMUNOTHERAPY; BIOENGINEERING; CELL DIFFERENTIATION; CELL FATE; CELL FUSION; CELL RENEWAL; EMBRYO CELL; HEMATOPOIETIC STEM CELL; HUMAN; MOLECULAR CLONING; NONHUMAN; PLASTICITY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0141687002     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2003.tb00209.x     Document Type: Review

References (70)

1. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., Campbell K.H., Viable offspring derived from fetal and adult mammalian cells, Nature, 385: 810-813, 1997
2. Brazelton T.R., Rossi F.M., Keshet G.I., Blau H.M., From marrow to brain: Expression of neuronal phenotypes in adult mice, Science, 290: 1775-1779, 2000
3. Krause D.S., Theise N.D., Collector M.I., Henegariu O., Hwang S., Gardner R., Neutzel S., Sharkis S.J., Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell, Cell 105: 369-377, 2001
4. Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., Wang X., Finegold M., Weissman I.L., Grompe M., Purified hematopoietic stem cells can differentiate into hepatocytes in vivo, Nat. Med., 6: 1229-1234, 2000
5. Ferrari G., Cusella-De Angelis G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F., Muscle regeneration by bone marrow-derived myogenic progenitors, Science, 279: 1528-1530, 1998
6. Galli R., Borello U., Gritti A., Minasi M.G., Bjornson C., Coletta M., Mora M., De Angelis M.G., Fiocco R., Cossu G., Vescovi A.L., Skeletal myogenic potential of human and mouse neural stem cells, Nat. Neurosci., 3: 986-991, 2000
7. Mezey E., Chandross K.J., Harta G., Maki R.A., McKercher S.R., Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow, Science, 290: 1779-1782, 2000
8. Bjornson C.R., Rietze R.L., Reynolds B.A., Magli M.C., Vescovi A.L., Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo, Science, 283: 534-537, 1999
9. Wang X., Willenbring H., Akkari Y., Torimaru Y., Foster M., Al-Dhalimy M., Lagasse E., Finegoid M., Olson S., Grompe M., Cell fusion is the principal source of bone-marrow-derived hepatocytes, Nature, 422: 897-901, 2003
10. Vassilopoulos G., Wang P.R., Russell D.W., Transplanted bone marrow regenerates liver by cell fusion, Nature, 422: 901-904, 2003
11. Terada N., Hamazaki T., Oka M., Hoki M., Mastalerz D.M., Nakano Y., Meyer E.M., Morel L., Petersen B.E., Scott E.W., Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion, Nature, 416: 542-545, 2002
12. Ying Q.L., Nichols J., Evans E.P., Smith A.G., Changing potency by spontaneous fusion, Nature, 416: 545-548, 2002
13. Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., Yates J.R., Nusse R., Wnt proteins are lipid-modified and can act as stem cell growth factors, Nature, 423: 448-452, 2003
14. Reya T., Duncan A.W., Ailles L., Domen J., Scherer D.C., Willert K., Hintz L., Nusse R., Weissman I.L., A role for wnt signalling in self-renewal of haematopoietic stem cells, Nature, 423: 409-414, 2003
15. Chambers I., Colby D., Robertson M., Nichols J., Lee S., Tweedie S., Smith A., Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells, Cell, 113: 643-655, 2003
16. Mitsui K., Tokuzawa Y., Itoh H., Segawa K., Murakami M., Takahashi K., Maruyama M., Maeda M., Yamanaka S., The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and es cells, Cell, 113: 631-642, 2003
17. Wang S.H., Tsai M.S., Chiang M.F., Li H., A novel nk-type homeobox gene, enk (early embryo specific nk), preferentially expressed in embryonic stem cells, Gene Expr. Patterns, 3: 99-103, 2003
18. Ramalho-Santos M., Yoon S., Matsuzaki Y., Mulligan R.C., Melton D.A., "Sternness": Transcriptional profiling of embryonic and adult stem cells, Science, 298: 597-600, 2002
19. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., Pickei J., McKay R., Nadal-Ginard B., Bodine D.M., Leri A., Anversa P., Bone marrow cells regenerate infarcted myocardium, Nature, 410: 701-705, 2001
20. Daley G.Q., Prospects for stem cell therapeutics: Myths and medicines, Curr. Opin. Genet. Dev., 12: 607-613, 2002
21. Wang X., Montini E., Al-Dhalimy M., Lagasse E., Finegold M., Grompe M., Kinetics of liver repopulation after bone marrow transplantation, Am. J. Pathol., 161: 565-574, 2002
22. Medvinsky A., Smith A., Stem cells: Fusion brings down barriers, Nature, 422: 823-825, 2003
23. Bradbury J., Wnt helps blood stem cells tick over, Lancet, 361: 1528, 2003
24. Cadigan K.M., Nusse R., Wnt signaling: A common theme in animal development, Genes Dev., 11: 3286-3305, 1997
25. Papkoff J., Schryver B., Secreted int-1 protein is associated with the cell surface, Mol. Cell. Biol., 10: 2723-2730, 1990
26. Antonchuk J., Sauvageau G., Humphries R.K., Hoxb4-induced expansion of adult hematopoietic stem cells ex vivo, Cell, 109: 39-45, 2002
27. Varnum-Finney B., Xu L., Brashem-Stein C., Nourigat C., Flowers D., Bakkour S., Pear W.S., Bernstein I.D., Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive notchl signaling, Nat Med., 6: 1278-1281, 2000
28. Domen J., Weissman I.L., Hematopoietic stem cells need two signals to prevent apoptosis; bcl-2 can provide one of these, kit1/c-kit signaling the other, J. Exp. Med., 192: 1707-1718, 2000
29. Haughn L., Hawley R.G., Morrison D.K., Von Boehmer H., Hockenbery D.M., Bcl-2 and bcl-xl restrict lineage choice during hematopoietic differentiation, J. Biol. Chem., 2003
30. Reya T., Regulation of hematopoietic stem cell self-renewal, Recent Prog. Horm. Res., 58: 283-295, 2003
31. Evans M.J., Kaufman M.H., Establishment in culture of pluripotential cells from mouse embryos, Nature, 292: 154-156, 1981
32. Martin G.R., Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells, Proc. Natl. Acad. Sci. USA, 78: 7634-7638, 1981
33. Watowich S.S., Wu H., Socolovsky M., Klingmuller U., Constantinescu S.N., Lodish H.F., Cytokine receptor signal transduction and the control of hematopoietic cell development, Ann. Rev. Cell Dev. Biol, 12: 91-128, 1996
34. Heinrich P.C., Behrmann I., Muller-Newen G., Schaper F., Graeve L., Interleukin-6-type cytokine signalling through the gp130/jak/stat pathway, Biochem. J., 334 (Pt 2): 297-314, 1998
35. Smith A.G., Heath J.K., Donaldson D.D., Wong G.G., Moreau J., Stahl M., Rogers D., Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides, Nature, 336: 688-690, 1988
36. Williams R.L., Hilton D.J., Pease S., Willson T.A., Stewart C.L., Gearing D.P., Wagner E.F., Metcalf D., Nicola N.A., Gough N.M., Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells, Nature, 336: 684-687, 1988
37. Yoshida K., Taga T., Saito M., Suematsu S., Kumanogoh A., Tanaka T., Fujiwara H., Hirata M., Yamagami T., Nakahata T., Hirabayashi T., Yoneda Y., Tanaka K., Wang W.Z., Mori C., Shiota K., Yoshida N., Kishimoto T., Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders, Proc. Natl Acad Sci. USA, 93: 407-411, 1996
38. Burdon T., Chambers I., Stracey C., Niwa H., Smith A., Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells, Cells Tissues Organs, 165: 131-143, 1999
39. Nichols J., Chambers I., Taga T., Smith A., Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines, Development, 128: 2333-2339, 2001
40. Stewart C.L., Kaspar P., Brunet L.J., Bhatt H., Gadi I., Kontgen F., Abbondanzo S.J., Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor, Nature, 359: 76-79, 1992
41. Palacios R., Steinmetz M., Il-3-dependent mouse clones that express b-220 surface antigen, contain ig genes in germ-line confguration, and generate b lymphocytes in vivo, Cell, 41: p727-734, 1985
42. Constantinescu S.N., Ghaffari S., Lodish H.F., The erythropoietin receptor: Structure, activation and intracellular signal transduction, Trends Endocrinol. Metab., 10: 18-23, 1999
43. Yoshimura A., Longmore G., Lodish H.F., Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity, Nature, 348: 647-649, 1990
44. Longmore G.D., Lodish H.F., An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene, Cell, 67: 1089-1102, 1991
45. Kabat D., Molecular biology of friend viral erythroleukemia, Curr. Top. Microbiol. Immunol., 148: 1-42, 1989
46. Li J.-P., D'Andrea A.D., Lodish H.F., Baltimore D., Activation of cell growth by binding of friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor, Nature, 343: 762-764, 1990
47. Onishi M., Mui A.L., Morikawa Y., Cho L., Kinoshita S., Nolan G.P., Gorman D.M., Miyajima A., Kitamura T., Identification of an oncogenic form of the thrombopoietin receptor mpl using retrovirus-mediated gene transfer, Blood, 88: 1399-1406., 1996
48. Berger C.N., Sturm K.S., Self renewal of embryonic stem cells in the absence of feeder cells and exogenous leukaemia inhibitory factor, Growth Factors, 14: 145-159, 1997
49. Dani C., Chambers I., Johnstone S., Robertsou M., Ebrahimi B., Saito M., Taga T., Li M., Burdon T., Nichols J., Smith A., Paracrine induction of stem cell renewal by lif-deficient cells: A new es cell regulatory pathway, Dev. Biol., 203: 149-162, 1998
50. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M., Embryonic stem cell lines derived from human blastocysts, Science, 282: 1145-1147, 1998
51. Reubinoff B.E., Pera M.F., Fong C.Y., Trounson A., Bongso A., Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro, Nat. Biotechnol., 18: 399-404, 2000
52. Gassmann M., Donoho G., Berg P., Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells, Proc. Natl. Acad. Sci. USA, 92: 1292-1296, 1995
53. Cavaleri F., Scholer H.R., Nanog. A new recruit to the embryonic stem cell orchestra, Cell, 113: 551-552, 2003
54. Harvey R.P., Nk-2 homeobox genes and heart development, Dev. Biol., 178: 203-216, 1996
55. Ryskov A.P., Ivanov P.L., Kramerov D.A., Georgiev G.P., Mouse ubiquitous b2 repeat in polysomal and cytoplasmic poly(a)+mas: Uniderectional orientation and 3′-end localization, Nucleic Acids Res, 11: 6541-6558, 1983
56. Ernst M., Oates A., Dunn A.R., Gp130-mediated signal transduction in embryonic stem cells involves activation of jak and ras/mitogen-activated protein kinase pathways, J. Biol. Chem., 271: 30136-30143, 1996
57. Ernst M., Novak U., Nicholson S.E., Layton J.E., Dunn A.R., The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of stat3, J. Biol. Chem., 274: 9729-9737, 1999
58. Niwa H., Burdon T., Chambers I., Smith A., Self-renewal of pluripotent embryonic stem cells is mediated via activation of stat3, Genes Dev., 12: 2048-2060, 1998
59. Matsuda T., Nakamura T., Nakao K., Arai T., Katsuki M., Heike T., Yokota T., Stat3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells, EMBO J., 18: 4261-4269, 1999
60. Scholer H.R., Dressler G.R., Balling R., Rohdewohld H., Gruss P., Oct-4: A germline-specific transcription factor mapping to the mouse t-complex, EMBO J., 9: 2185-2195, 1990
61. Niwa H., Miyazaki J., Smith A.G., Quantitative expression of oct-3/4 defines differentiation, dedifferentiation or self-renewal of es cells, Nat. Genet., 24: 372-376, 2000
62. Burdon T., Stracey C., Chambers I., Nichols J., Smith A., Suppression of shp-2 and erk signalling promotes self-renewal of mouse embryonic stem cells, Dev. Biol., 210: 30-43, 1999
63. Takahashi K., Mitsui K., Yamanaka S., Role of eras in promoting tumour-like properties in mouse embryonic stem cells, Nature, 423: 541-545, 2003
64. Hanna L.A., Foreman R.K., Tarasenko I.A., Kessler D.S., Labosky P.A., Requirement for foxd3 in maintaining pluripotent cells of the early mouse embryo, Genes Dev., 16: 2650-2661, 2002
65. Avilion A.A., Nicolis S.K., Pevny L.H., Perez L., Vivian N., Lovell-Badge R., Multipotent cell lineages in early mouse development depend on sox2 function, Genes Dev., 17: 126-140, 2003
66. Fujikura J., Yamato E., Yonemura S., Hosoda K., Masui S., Nakao K., Miyazaki Ji J., Niwa H., Differentiation of embryonic stem cells is induced by gata factors, Genes Dev., 16: 784-789, 2002
67. Morrisey E.E., Tang Z., Sigrist K., Lu M.M., Jiang F., Ip H.S., Parmacek M.S., Gata6 regulates hnf4 and is required for differentiation of visceral endoderm in the mouse embryo, Genes Dev., 12: 3579-3590, 1998
68. Gurdon J.B., Byrne J.A., The first half-century of nuclear transplantation, Proc. Natl. Acad. Sci. USA, 2003
69. Jiang Y., Jahagirdar B.N., Reinhardt R.L., Schwartz R.E., Keene C.D., Ortiz-Gonzalez X.R., Reyes M., Lenvik T., Lund T., Blackstad M., Du J., Aldrich S., Lisberg A., Low W.C., Largaespada D.A., Verfaillie C.M., Pluripotency of mesenchymal stem cells derived from adult marrow, Nature, 418: 41-49, 2002
70. Constantinescu S.N., Stem cell generation and choice of fate: Role of cytokines and cellular microenvironment, J. Cell. Mol. Med., 4: 233-248, 2000