KLF4 is a FOXO target gene that suppresses B cell proliferation

International Immunology

Volumn 20, Issue 5, 2008, Pages 671-681

  Yusuf, Isharat ^a,d   Kharas, Michael G ^a   Chen, Jing ^a   Peralta, Raechel Q ^a   Maruniak, Autumn ^a   Sareen, Pratibha ^a   Yang, Vincent W ^b   Kaestner, Klaus H ^c   Fruman, David A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

B lymphocyte; Quiescence; Transcription factor; Tumor suppressor

Indexed keywords

KRUPPEL LIKE FACTOR 4; PHOSPHATIDYLINOSITOL 3 KINASE; RNA; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BLAST CELL; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DEATH; CELL MATURATION; CELL PROLIFERATION; CELL SPECIFICITY; CHROMATIN IMMUNOPRECIPITATION; CORRELATION FUNCTION; DNA BINDING; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; TRANSCRIPTION REGULATION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; B-LYMPHOCYTES; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS;

EID: 42949145380     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn024     Document Type: Article

References (43)

1. Dang, D. T., Pevsner, J. and Yang, V. W. 2000. The biology of the mammalian Kruppel-like family of transcription factors. Int. J. Biochem. Cell Biol. 32:1103.
2. Kaczynski, J., Cook, T. and Urrutia, R. 2003. Sp1 - and Kruppel-like transcription factors. Genome Biol. 4:206.
3. Turner, J. and Crossley, M. 1999. Mammalian Kruppel-like transcription factors: More than just a pretty finger. Trends Biochem. Sci. 24:236.
4. Katz, J. P., Perreault, N., Goldstein, B. G. et al. 2005. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology 128:935.
5. Yasunaga, J., Taniguchi, Y., Nosaka, K. et al. 2004. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res. 64:6002.
6. Rowland, B. D., Bernards, R. and Peeper, D. S. 2005. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat. Cell Biol. 7:1074.
7. Segre, J. A, Bauer, C. and Fuchs, E. 1999. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22:356.
8. Wernig, M., Meissner, A., Foreman, R. et al. 2007. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 488:553.
9. Okita, K., Ichisaka, T. and Yamanaka, S. 2007. Generation of germline-competent induced pluripotent stem cells. Nature 488:313.
10. Takahashi, K. and Yamanaka, S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663.
11. Kharas, M. G., Yusuf, I., Scarfone, V. M. et al. 2007. KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood 109:747.
12. Chen, J., Yusuf, I., Andersen, H. M. and Fruman, D. A. 2006. FOXO transcription factors cooperate with {delta}EF1 to activate growth suppressive genes in B lymphocytes. J. Immunol. 176:2711.
13. Katz, J. P., Perreault, N., Goldstein, B. G. et al. 2002. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129:2619.
14. Donahue, A. C. and Fruman, D. A. 2003. Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J. Immunol. 170:5851.
15. Yusuf, I., Zhu, X., Kharas, M. G., Chen, J. and Fruman, D. A. 2004. Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors. Blood 104:784.
16. Kharas, M. G., Deane, J. A., Wong, S. et al. 2004. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood 103:4268.
17. Fruman, D. A. Ferl, G. Z., An, S. S., Donahue, A. C., Satterthwaite, A. B. and Witte, O. N. 2002. Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc. Natl Acad. Sci. USA 99:359.
18. Shields, J. M., Christy, R. J. and Yang, V. W. 1996. Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J. Biol. Chem. 271:20009.
19. Glynne, R., Ghandour, G., Rayner, J., Mack, D. H. and Goodnow, C. C. 2000. B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunol. Rev. 176:216.
20. Glynne, R., Akkaraju, S., Healy, J. I., Rayner, J., Goodnow, C. C. and Mack, D. H. 2000. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 403:672.
21. Buckley, A. F., Kuo, C. T. and Leiden, J. M. 2001. Transcription factor LKLF is sufficient to-program T cell quiescence via a c-Myc-dependent pathway. Nat. Immunol. 2:698.
22. Shie, J. L., Chen, Z. Y., Fu, M., Pestell, R. G. and Tseng, C. C. 2000. Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res. 28:2969.
23. Zhang, W., Geiman, D. E., Shields, J. M. et al. 2000. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J. Biol. Chem. 275:18391.
24. Chiles, T. C. 2004. Regulation and function of cyclin D2 in B lymphocyte subsets. J. Immunol. 173:2901.
25. Lacy, J., Sarkar, S. N. and Summers, W. C. 1986. Induction of c-myc expression in human B lymphocytes by B-cell growth factor and anti-immunoglobulin. Proc. Natl Acad. Sci. USA 83:1458.
26. Niiro, H. and Clark, E. A. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2:945.
27. Knight, Z. A., Gonzalez, B., Feldman, M. E. et al. 2006. A pharmacological map of the Pl3-K family defines a role for p 110alpha in insulin signaling. Cell 125:733.
28. Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, J. C. Jr and Abraham, R. T. 1996. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15:5256.
29. Lin, L., Hron, J. D. and Peng, S. L. 2004. Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21:203.
30. Kops, G. J., Medema, R. H., Glassford, J. et al. 2002. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol. 22:2025.
31. Donahue, A. C. and Fruman, D. A. 2004. Pl3K signaling controls cell fate at many points in B lymphocyte development and activation. Semin. Cell Dev. Biol. 15:183.
32. Burgering, B. M. and Kops, G. J. 2002. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci. 27:352.
33. Tran, H., Brunet, A., Griffith, E. C. and Greenberg, M. E. 2003. The many forks in FOXO's road. Sci. STKE 2003:RE5.
34. Jonsson, H. and Peng, S. L. 2005. Forkhead transcription factors in immunology. Cell. Mol. Life Sci. 62:397.
35. Yusuf, I. and Fruman, D. A. 2003. Regulation of quiescence in lymphocytes. Trends Immunol. 24:380.
36. Kuo, C. T., Veselits, M. L. and Leiden, J. M. 1997. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science 277:1986.
37. Carlson, C. M., Endrizzi, B. T., Wu, J. et al. 2006. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442:299.
38. Haaland, R. E., Yu, W. and Rice, A. P. 2005. Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes. Mol. Immunol. 42:627.
39. Wu, J. and Lingrel, J. B. 2004. KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/ CIP1. Oncogene 23:8088.
40. Lin, L., Spoor, M, S., Gerth, A. J., Brody, S. L. and Peng, S. L. 2004. Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Science 303:1017.
41. Good, K. L. and Tangye, S. G. 2007. Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses. Proc. Natl Acad. Sci. USA 104:13420.
42. Klaewsongkram, J., Yang, Y., Golech, S., Katz, J., Kaestner, K. H. and Weng, N. P. 2007. Kruppel-like factor 4 regulates B cell number and activation-induced B cell proliferation. J. Immunol. 179:4679.
43. Medina, K. L., Pongubala, J. M., Reddy, K. L. et al. 2004. Assembling a gene regulatory network for specification of the B cell fate. Dev. Cell 7:607.