메뉴 건너뛰기




Volumn 20, Issue 3, 2010, Pages 133-142

The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CHLOROQUINE; CIDOFOVIR; CYCLIN DEPENDENT KINASE INHIBITOR; IDOXURIDINE; OLOMOUCINE II; RIBAVIRIN; ROSCOVITINE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CYCLIN DEPENDENT KINASE; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE;

EID: 77649226169     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1460     Document Type: Article
Times cited : (20)

References (47)
  • 1
    • 33846004815 scopus 로고    scopus 로고
    • Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs
    • Schang LM, St Vincent MR, Lacasse JJ. Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs. Antivir Chem Chemother 2006; 17:293-320.
    • (2006) Antivir Chem Chemother , vol.17 , pp. 293-320
    • Schang, L.M.1    St Vincent, M.R.2    Lacasse, J.J.3
  • 2
    • 0026721068 scopus 로고
    • A family of human cdc2-related protein kinases
    • Meyerson M, Enders GH, Wu CL, et al. A family of human cdc2-related protein kinases. EMBO J 1992; 11:2909-2917.
    • (1992) EMBO J , vol.11 , pp. 2909-2917
    • Meyerson, M.1    Enders, G.H.2    Wu, C.L.3
  • 3
    • 0035865203 scopus 로고    scopus 로고
    • Can sequencing shed light on cell cycling?
    • Murray AW, Marks D. Can sequencing shed light on cell cycling? Nature 2001; 409:844-846.
    • (2001) Nature , vol.409 , pp. 844-846
    • Murray, A.W.1    Marks, D.2
  • 5
    • 0036710767 scopus 로고    scopus 로고
    • Pharmacological inhibitors of cyclin-dependent kinases
    • Knockaert M, Greengard P, Meijer L. Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci 2002; 23:417-425.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 417-425
    • Knockaert, M.1    Greengard, P.2    Meijer, L.3
  • 6
    • 0034721195 scopus 로고    scopus 로고
    • Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
    • Arris CE, Boyle FT, Calvert AH, et al. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem 2000; 43:2797-2804.
    • (2000) J Med Chem , vol.43 , pp. 2797-2804
    • Arris, C.E.1    Boyle, F.T.2    Calvert, A.H.3
  • 7
    • 0031028163 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinases by purine analogues: Crystal structure of human cdk2 complexed with roscovitine
    • De Azevedo WF, Leclerc S, Meijer L, et al. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem 1997; 243:518-526.
    • (1997) Eur J Biochem , vol.243 , pp. 518-526
    • De Azevedo, W.F.1    Leclerc, S.2    Meijer, L.3
  • 8
    • 0028093182 scopus 로고
    • Inhibition of cyclindependent kinases by purine analogues
    • Vesely J, Havlicek L, Strnad M, et al. Inhibition of cyclindependent kinases by purine analogues. Eur J Biochem 1994; 224:771-786.
    • (1994) Eur J Biochem , vol.224 , pp. 771-786
    • Vesely, J.1    Havlicek, L.2    Strnad, M.3
  • 10
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    • Meijer L, Borgne A, Mulner O, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 1997; 243:527-536.
    • (1997) Eur J Biochem , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3
  • 12
    • 23844525170 scopus 로고    scopus 로고
    • Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
    • Kryštof V, McNae IW, Walkinshaw MD, et al. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci 2005; 62:1763-1771.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1763-1771
    • Kryštof, V.1    McNae, I.W.2    Walkinshaw, M.D.3
  • 13
    • 0034812298 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382
    • Ljungman M, Paulsen MT. The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. Mol Pharmacol 2001; 60:785-789.
    • (2001) Mol Pharmacol , vol.60 , pp. 785-789
    • Ljungman, M.1    Paulsen, M.T.2
  • 14
    • 4143120023 scopus 로고    scopus 로고
    • Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors
    • Diwan P, Lacasse JJ, Schang LM. Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors. J Virol 2004; 78:9352-9365.
    • (2004) J Virol , vol.78 , pp. 9352-9365
    • Diwan, P.1    Lacasse, J.J.2    Schang, L.M.3
  • 15
    • 0031009357 scopus 로고    scopus 로고
    • Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication
    • Bresnahan WA, Boldogh I, Chi P, Thompson EA, Albrecht T. Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication. Virology 1997; 231:239-247.
    • (1997) Virology , vol.231 , pp. 239-247
    • Bresnahan, W.A.1    Boldogh, I.2    Chi, P.3    Thompson, E.A.4    Albrecht, T.5
  • 16
    • 14444281157 scopus 로고    scopus 로고
    • P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro
    • Mancebo HS, Lee G, Flygare J, et al. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev 1997; 11:2633-2644.
    • (1997) Genes Dev , vol.11 , pp. 2633-2644
    • Mancebo, H.S.1    Lee, G.2    Flygare, J.3
  • 17
    • 0031746015 scopus 로고    scopus 로고
    • Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription
    • Schang LM, Phillips J, Schaffer PA. Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription. J Virol 1998; 72:5626-5637.
    • (1998) J Virol , vol.72 , pp. 5626-5637
    • Schang, L.M.1    Phillips, J.2    Schaffer, P.A.3
  • 18
    • 0036310685 scopus 로고    scopus 로고
    • Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins
    • Schang LM, Bantly A, Knockaert M, et al. Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. J Virol 2002; 76:7874-7882.
    • (2002) J Virol , vol.76 , pp. 7874-7882
    • Schang, L.M.1    Bantly, A.2    Knockaert, M.3
  • 19
    • 0034910933 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors
    • Wang D, de la Fuente C, Deng L, et al. Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. J Virol 2001; 75:7266-7279.
    • (2001) J Virol , vol.75 , pp. 7266-7279
    • Wang, D.1    de la Fuente, C.2    Deng, L.3
  • 20
    • 0036686954 scopus 로고    scopus 로고
    • Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors
    • Wang L, Deng L, Wu K, et al. Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors. Mol Cell Biochem 2002; 237:137-153.
    • (2002) Mol Cell Biochem , vol.237 , pp. 137-153
    • Wang, L.1    Deng, L.2    Wu, K.3
  • 21
    • 0346365302 scopus 로고    scopus 로고
    • Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication
    • Kudoh A, Daikoku T, Sugaya Y, et al. Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication. J Virol 2004; 78:104-115.
    • (2004) J Virol , vol.78 , pp. 104-115
    • Kudoh, A.1    Daikoku, T.2    Sugaya, Y.3
  • 22
    • 0036147535 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0
    • Davido DJ, Leib DA, Schaffer PA. The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0. J Virol 2002; 76:1077-1088.
    • (2002) J Virol , vol.76 , pp. 1077-1088
    • Davido, D.J.1    Leib, D.A.2    Schaffer, P.A.3
  • 23
    • 37349126983 scopus 로고    scopus 로고
    • Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome
    • Kapasi AJ, Spector DH. Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome. J Virol 2008; 82:394-407.
    • (2008) J Virol , vol.82 , pp. 394-407
    • Kapasi, A.J.1    Spector, D.H.2
  • 24
    • 0034665961 scopus 로고    scopus 로고
    • Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
    • Chao SH, Fujinaga K, Marion JE, et al. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J Biol Chem 2000; 275:28345-28348.
    • (2000) J Biol Chem , vol.275 , pp. 28345-28348
    • Chao, S.H.1    Fujinaga, K.2    Marion, J.E.3
  • 25
    • 0033053592 scopus 로고    scopus 로고
    • Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases
    • Schang LM, Rosenberg A, Schaffer PA. Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases. J Virol 1999; 73:2161-2172.
    • (1999) J Virol , vol.73 , pp. 2161-2172
    • Schang, L.M.1    Rosenberg, A.2    Schaffer, P.A.3
  • 26
    • 0033375469 scopus 로고    scopus 로고
    • Flavopiridol: The first cyclin-dependent kinase inhibitor in human clinical trials
    • Senderowicz AM. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Invest New Drugs 1999; 17:313-320.
    • (1999) Invest New Drugs , vol.17 , pp. 313-320
    • Senderowicz, A.M.1
  • 27
    • 0029814850 scopus 로고    scopus 로고
    • Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific
    • Nicholl MJ, Preston CM. Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific. J Virol 1996; 70:6336-6339.
    • (1996) J Virol , vol.70 , pp. 6336-6339
    • Nicholl, M.J.1    Preston, C.M.2
  • 28
    • 0031029580 scopus 로고    scopus 로고
    • Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-α in hematopoietic cell lines
    • Sangfelt O, Erickson S, Einhorn S, Grander D. Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-α in hematopoietic cell lines. Oncogene 1997; 14:415-423.
    • (1997) Oncogene , vol.14 , pp. 415-423
    • Sangfelt, O.1    Erickson, S.2    Einhorn, S.3    Grander, D.4
  • 29
    • 0028978667 scopus 로고
    • Cyclin A and Cdk2 kinase activity are suppressed by combined treatment with tumor necrosis factor-α and interferon-α
    • Satomoto K, Haisa M, Naomoto Y, Tanaka N, Orita K. Cyclin A and Cdk2 kinase activity are suppressed by combined treatment with tumor necrosis factor-α and interferon-α. Biochem Biophys Res Commun 1995; 213:1115-1121.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 1115-1121
    • Satomoto, K.1    Haisa, M.2    Naomoto, Y.3    Tanaka, N.4    Orita, K.5
  • 30
    • 0032518668 scopus 로고    scopus 로고
    • Interferon-induces expression of cyclin-dependent kinaseinhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK)
    • Mandal M, Bandyopadhyay D, Goepfert TM, Kumar R. Interferon-induces expression of cyclin-dependent kinaseinhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK). Oncogene 1998; 16:217-225.
    • (1998) Oncogene , vol.16 , pp. 217-225
    • Mandal, M.1    Bandyopadhyay, D.2    Goepfert, T.M.3    Kumar, R.4
  • 31
    • 0031055563 scopus 로고    scopus 로고
    • Cytokinin-derived cyclin-dependent kinase inhibitors: Synthesis and cdc2 inhibitory activity of olomoucine and related compounds
    • Havlicek L, Hanus J, Vesely J, et al. Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. J Med Chem 1997; 40:408-412.
    • (1997) J Med Chem , vol.40 , pp. 408-412
    • Havlicek, L.1    Hanus, J.2    Vesely, J.3
  • 32
    • 0023128405 scopus 로고
    • Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
    • Gotch F, McMichael A, Smith G, Moss B. Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes. J Exp Med 1987; 165:408-416.
    • (1987) J Exp Med , vol.165 , pp. 408-416
    • Gotch, F.1    McMichael, A.2    Smith, G.3    Moss, B.4
  • 33
    • 7444237148 scopus 로고    scopus 로고
    • Characterization and manipulation of the human adenovirus 4 genome
    • Jacobs SC, Davison AJ, Carr S, et al. Characterization and manipulation of the human adenovirus 4 genome. J Gen Virol 2004; 85:3361-3366.
    • (2004) J Gen Virol , vol.85 , pp. 3361-3366
    • Jacobs, S.C.1    Davison, A.J.2    Carr, S.3
  • 34
    • 0041351951 scopus 로고    scopus 로고
    • The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro
    • McSharry BP, Tomasec P, Neale ML, Wilkinson GW. The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro. J Gen Virol 2003; 84:2511-2516.
    • (2003) J Gen Virol , vol.84 , pp. 2511-2516
    • McSharry, B.P.1    Tomasec, P.2    Neale, M.L.3    Wilkinson, G.W.4
  • 36
    • 0035891288 scopus 로고    scopus 로고
    • 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
    • Nguyen VT, Kiss T, Michels AA, Bensaude O. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature 2001; 414:322-325.
    • (2001) Nature , vol.414 , pp. 322-325
    • Nguyen, V.T.1    Kiss, T.2    Michels, A.A.3    Bensaude, O.4
  • 37
    • 0037071899 scopus 로고    scopus 로고
    • Physical interaction between pRb and cdk9/cyclinT2 complex
    • Simone C, Bagella L, Bellan C, Giordano A. Physical interaction between pRb and cdk9/cyclinT2 complex. Oncogene 2002; 21:4158-4165.
    • (2002) Oncogene , vol.21 , pp. 4158-4165
    • Simone, C.1    Bagella, L.2    Bellan, C.3    Giordano, A.4
  • 38
    • 0036275982 scopus 로고    scopus 로고
    • Phosphorylation of the RNA polymerase II carboxylterminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation
    • Kim YK, Bourgeois CF, Isel C, Churcher MJ, Karn J. Phosphorylation of the RNA polymerase II carboxylterminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Mol Cell Biol 2002; 22:4622-4637.
    • (2002) Mol Cell Biol , vol.22 , pp. 4622-4637
    • Kim, Y.K.1    Bourgeois, C.F.2    Isel, C.3    Churcher, M.J.4    Karn, J.5
  • 40
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan DO. Principles of CDK regulation. Nature 1995; 374:131-134.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 41
    • 27144458683 scopus 로고    scopus 로고
    • Cyclins and CDKS in development and cancer: Lessons from genetically modified mice
    • Santamaria D, Ortega S. Cyclins and CDKS in development and cancer: lessons from genetically modified mice. Front Biosci 2006; 11:1164-1188.
    • (2006) Front Biosci , vol.11 , pp. 1164-1188
    • Santamaria, D.1    Ortega, S.2
  • 42
    • 0034121281 scopus 로고    scopus 로고
    • Cell cycle molecular targets in novel anticancer drug discovery
    • Buolamwini JK. Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Des 2000; 6:379-392.
    • (2000) Curr Pharm Des , vol.6 , pp. 379-392
    • Buolamwini, J.K.1
  • 43
    • 0018648470 scopus 로고
    • Biogenesis of poxviruses: Role for the DNA-dependent RNA polymerase II of the host during expression of late functions
    • Silver M, McFadden G, Wilton S, Dales S. Biogenesis of poxviruses: role for the DNA-dependent RNA polymerase II of the host during expression of late functions. Proc Natl Acad Sci U S A 1979; 76:4122-4125.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 4122-4125
    • Silver, M.1    McFadden, G.2    Wilton, S.3    Dales, S.4
  • 44
    • 38849091239 scopus 로고    scopus 로고
    • Vaccinia virus-mediated cell cycle alteration involves inactivation of tumour suppressors associated with Brf1 and TBP
    • Yoo NK, Pyo CW, Kim Y, Ahn BY, Choi SY. Vaccinia virus-mediated cell cycle alteration involves inactivation of tumour suppressors associated with Brf1 and TBP. Cell Microbiol 2008; 10:583-592.
    • (2008) Cell Microbiol , vol.10 , pp. 583-592
    • Yoo, N.K.1    Pyo, C.W.2    Kim, Y.3    Ahn, B.Y.4    Choi, S.Y.5
  • 45
    • 0037310655 scopus 로고    scopus 로고
    • Adenovirus: An increasingly important pathogen in paediatric bone marrow transplant patients
    • Walls T, Shankar AG, Shingadia D. Adenovirus: an increasingly important pathogen in paediatric bone marrow transplant patients. Lancet Infect Dis 2003; 3:79-86.
    • (2003) Lancet Infect Dis , vol.3 , pp. 79-86
    • Walls, T.1    Shankar, A.G.2    Shingadia, D.3
  • 46
    • 0034858413 scopus 로고    scopus 로고
    • Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation
    • Hoffman JA, Shah AJ, Ross LA, Kapoor N. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7:388-394.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 388-394
    • Hoffman, J.A.1    Shah, A.J.2    Ross, L.A.3    Kapoor, N.4
  • 47
    • 0037366835 scopus 로고    scopus 로고
    • Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: A survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
    • Ljungman P, Ribaud P, Eyrich M, et al. Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2003; 31:481-486.
    • (2003) Bone Marrow Transplant , vol.31 , pp. 481-486
    • Ljungman, P.1    Ribaud, P.2    Eyrich, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.