Protein tyrosine phosphatases in glioma biology

Acta Neuropathologica

Volumn 119, Issue 2, 2010, Pages 157-175

  Navis, Anna C ^a   Van Den Eijnden, Monique ^b   Schepens, Jan T G ^a   Hooft Van Huijsduijnen, Rob ^b   Wesseling, Pieter ^a   Hendriks, Wiljan J A J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MERCK SERONO S A   (Switzerland)

Author keywords

Signal transduction; Tyrosine phosphorylation

Indexed keywords

ANTINEOPLASTIC AGENT; AZIXA; BANOXANTRONE; BEVACIZUMAB; BSI 201; CARMUSTINE; CDX 110; COTARA; CYT 997; ICT 107; ICT 121; LOMUSTINE; MONOCLONAL ANTIBODY; MP 470; MPC 6827; NIMOTUZUMAB; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 13; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RAPAMYCIN; SAPORIN; TEMOZOLOMIDE; TLN 4601; TM 601; TYROSINE; UNCLASSIFIED DRUG; XL 184;

BRAIN TUMOR; CANCER GROWTH; CANCER THERAPY; CARCINOGENESIS; CLINICAL TRIAL; DRUG TARGETING; GLIA CELL; GLIOBLASTOMA; GLIOMA; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; ENZYMOLOGY; METABOLISM; PHYSIOLOGY;

ANIMALS; BRAIN NEOPLASMS; GLIOMA; HUMANS; PROTEIN TYROSINE PHOSPHATASES; SIGNAL TRANSDUCTION;

EID: 77449152204     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-009-0614-0     Document Type: Review

References (163)

1. OD Abaan A Levenson O Khan PA Furth A Uren JA Toretsky 2005 PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis Oncogene 24 2715 2722 1:CAS:528:DC%2BD2MXjtFOkurk%3D 15782144
2. OD Abaan JA Toretsky 2008 PTPL1: a large phosphatase with a split personality Cancer Metastasis Rev 27 205 214 1:CAS:528:DC%2BD1cXlt1CktbY%3D 18265946
3. R Abounader 2009 Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy Expert Rev Anticancer Ther 9 235 245 1:CAS:528:DC%2BD1MXhsVykurs%3D 19192961
4. Y Akasaki G Liu HH Matundan H Ng X Yuan Z Zeng KL Black JS Yu 2006 A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells J Biol Chem 281 6165 6174 1:CAS:528:DC%2BD28XhvFOhtb0%3D 16319070
5. K Aldape H Colman CD James 2006 Models of malignant glioma Drug Discov Today Dis Models 3 191 196
6. A Alonso J Sasin N Bottini I Friedberg A Osterman A Godzik T Hunter J Dixon T Mustelin 2004 Protein tyrosine phosphatases in the human genome Cell 117 699 711 1:CAS:528:DC%2BD2cXltlKisbc%3D 15186772 (Pubitemid 38748887)
7. AR Aricescu C Siebold K Choudhuri VT Chang W Lu SJ Davis PA van der Merwe EY Jones 2007 Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism Science 317 1217 1220 1:CAS:528:DC%2BD2sXps12ms7k%3D 17761881
8. D Barford Z Jia NK Tonks 1995 Protein tyrosine phosphatases take off Nat Struct Biol 2 1043 1053 1:CAS:528:DyaK2MXpvV2mtrc%3D 8846213
9. M Bentires-Alj BG Neel 2007 Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer Cancer Res 67 2420 2424 1:CAS:528: DC%2BD2sXivV2gurg%3D 17347513
10. SH Bigner PA Humphrey AJ Wong B Vogelstein J Mark HS Friedman DD Bigner 1990 Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts Cancer Res 50 8017 8022 1:CAS:528:DyaK3MXls1ejuw%3D%3D 2253244
11. JD Bjorge A Pang DJ Fujita 2000 Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines J Biol Chem 275 41439 41446 1:CAS:528:DC%2BD3MXjsVKhuw%3D%3D 11007774
12. MA Bjornsti PJ Houghton 2004 The TOR pathway: a target for cancer therapy Nat Rev Cancer 4 335 348 1:CAS:528:DC%2BD2cXjsFSlu7Y%3D 15122205
13. R Boutros V Lobjois B Ducommun 2007 CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 7 495 507 1:CAS:528: DC%2BD2sXmvVakurg%3D 17568790
14. TM Bryan TR Cech 1999 Telomerase and the maintenance of chromosome ends Curr Opin Cell Biol 11 318 324 1:CAS:528:DyaK1MXktFWmsrY%3D 10395557
15. Burgoyne AM, Palomo JM, Phillips-Mason PJ, Burden-Gulley SM, Major DL, Zaremba A, Robinson S, Sloan AE, Vogelbaum MA, Miller RH, Brady-Kalnay SM (2009) PTPmu suppresses glioma cell migration and dispersal. Neuro Oncol. doi: 10.1215/15228517-15222009-15228019
16. AM Burgoyne PJ Phillips-Mason SM Burden-Gulley S Robinson AE Sloan RH Miller SM Brady-Kalnay 2009 Proteolytic cleavage of protein tyrosine phosphatase μ regulates glioblastoma cell migration Cancer Res 69 6960 6968 1:CAS:528:DC%2BD1MXhtVOmtL3J 19690139
17. Cancer Genome Atlas Research Network 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 1061 1068
18. PD Canoll S Petanceska J Schlessinger JM Musacchio 1996 Three forms of RPTP-beta are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture J Neurosci Res 44 199 215 1:CAS:528:DyaK28XislCisLo%3D 8723759
19. P Champion-Arnaud MC Gesnel N Foulkes C Ronsin P Sassone-Corsi R Breathnach 1991 Activation of transcription via AP-1 or CREB regulatory sites is blocked by protein tyrosine phosphatases Oncogene 6 1203 1209 1:CAS:528:DyaK38XmtVKisrY%3D 1650442
20. G Chan D Kalaitzidis BG Neel 2008 The tyrosine phosphatase Shp2 (PTPN11) in cancer Cancer Metastasis Rev 27 179 192 1:CAS:528:DC%2BD1cXlt1Ckur4%3D 18286234
21. AK Chauhan YS Li TF Deuel 1993 Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice Proc Natl Acad Sci USA 90 679 682 1:CAS:528:DyaK3sXpvFamug%3D%3D 8421705
22. CK Cheng Q-W Fan WA Weiss 2009 PI3K signaling in glioma: animal models and therapeutic challenges Brain Pathol 19 112 120 1:CAS:528: DC%2BD1MXitVWht7w%3D 19076776
23. JP Chow A Fujikawa H Shimizu R Suzuki M Noda 2008 Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z J Biol Chem 283 30879 30889 1:CAS:528:DC%2BD1cXhtlWjtLzK 18713734
24. A Claes AJ Idema P Wesseling 2007 Diffuse glioma growth: a guerilla war Acta Neuropathol 114 443 458 17805551
25. A Claes J Schuuring S Boots-Sprenger S Hendriks-Cornelissen M Dekkers AJ van der Kogel WP Leenders P Wesseling JW Jeuken 2008 Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy Brain Pathol 18 423 433 18371177
26. TF Cloughesy K Yoshimoto P Nghiemphu K Brown J Dang S Zhu T Hsueh Y Chen W Wang D Youngkin L Liau N Martin D Becker M Bergsneider A Lai R Green T Oglesby M Koleto J Trent S Horvath PS Mischel IK Mellinghoff CL Sawyers 2008 Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma PLoS Med 5 e8 18215105
27. PJ Cook BG Ju F Telese X Wang CK Glass MG Rosenfeld 2009 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions Nature 458 591 596 1:CAS:528:DC%2BD1MXitFKls7k%3D 19234442
28. DE Cool NK Tonks H Charbonneau KA Walsh EH Fischer EG Krebs 1989 cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family Proc Natl Acad Sci USA 86 5257 5261 1:CAS:528:DyaK3cXhslehur8%3D 2546150
29. C Cox G Bignell C Greenman A Stabenau W Warren P Stephens H Davies S Watt J Teague S Edkins E Birney DF Easton R Wooster PA Futreal MR Stratton 2005 A survey of homozygous deletions in human cancer genomes Proc Natl Acad Sci USA 102 4542 4547 1:CAS:528:DC%2BD2MXivFCqsr0%3D 15761058
30. PC De Witt Hamer AA Van Tilborg PP Eijk P Sminia D Troost CJ Van Noorden B Ylstra S Leenstra 2008 The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids Oncogene 27 2091 2096 17934519
31. L Ding G Getz DA Wheeler ER Mardis MD McLellan K Cibulskis C Sougnez H Greulich DM Muzny MB Morgan L Fulton RS Fulton Q Zhang MC Wendl MS Lawrence DE Larson K Chen DJ Dooling A Sabo AC Hawes H Shen SN Jhangiani LR Lewis O Hall Y Zhu T Mathew Y Ren J Yao SE Scherer K Clerc GA Metcalf B Ng A Milosavljevic ML Gonzalez-Garay JR Osborne R Meyer X Shi Y Tang DC Koboldt L Lin R Abbott TL Miner C Pohl G Fewell C Haipek H Schmidt BH Dunford-Shore A Kraja SD Crosby CS Sawyer T Vickery S Sander J Robinson W Winckler J Baldwin LR Chirieac A Dutt T Fennell M Hanna BE Johnson RC Onofrio RK Thomas G Tonon BA Weir X Zhao L Ziaugra MC Zody T Giordano MB Orringer JA Roth MR Spitz II Wistuba B Ozenberger PJ Good AC Chang DG Beer MA Watson M Ladanyi S Broderick A Yoshizawa WD Travis W Pao MA Province GM Weinstock HE Varmus SB Gabriel ES Lander RA Gibbs M Meyerson RK Wilson 2008 Somatic mutations affect key pathways in lung adenocarcinoma Nature 455 1069 1075 1:CAS:528:DC%2BD1cXht1yju73J 18948947
32. N Dube A Bourdeau KM Heinonen A Cheng AL Loy ML Tremblay 2005 Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development Cancer Res 65 10088 10095 1:CAS:528:DC%2BD2MXhtFKkt7rK 16267035
33. N Dube A Cheng ML Tremblay 2004 The role of protein tyrosine phosphatase 1B in Ras signaling Proc Natl Acad Sci USA 101 1834 1839 1:CAS:528: DC%2BD2cXhs1SktLw%3D 14766979
34. N Dube ML Tremblay 2005 Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer Biochim Biophys Acta 1754 108 117 1:CAS:528:DC%2BD2MXhtlags7nM 16198645
35. R Endersby SJ Baker 2008 PTEN signaling in brain: neuropathology and tumorigenesis Oncogene 27 5416 5430 1:CAS:528:DC%2BD1cXhtFWiur3N 18794877
36. C Eng 2003 PTEN: one gene, many syndromes Hum Mutat 22 183 198 1:CAS:528:DC%2BD3sXos12msLo%3D 12938083
37. SD Finkelstein P Black TP Nowak CM Hand S Christensen PW Finch 1994 Histological characteristics and expression of acidic and basic fibroblast growth factor genes in intracerebral xenogeneic transplants of human glioma cells Neurosurgery 34 136 143 1:STN:280:DyaK2c7ms12msg%3D%3D 7510050
38. ED Foehr G Lorente J Kuo R Ram K Nikolich R Urfer 2006 Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model Cancer Res 66 2271 2278 1:CAS:528:DC%2BD28XhsFalsL4%3D 16489031
39. ED Foehr G Lorente V Vincent K Nikolich R Urfer 2005 FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS J Neurooncol 74 241 248 1:CAS:528:DC%2BD2MXht12hurjF 16187021
40. EI Fomchenko EC Holland 2006 Mouse models of brain tumors and their applications in preclinical trials Clin Cancer Res 12 5288 5297 1:CAS:528:DC%2BD28XpvFShs70%3D 17000661
41. MM Fraser X Zhu CH Kwon EJ Uhlmann DH Gutmann SJ Baker 2004 Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo Cancer Res 64 7773 7779 1:CAS:528:DC%2BD2cXptFemu78%3D 15520182
42. M Fukada A Fujikawa JP Chow S Ikematsu S Sakuma M Noda 2006 Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization FEBS Lett 580 4051 4056 1:CAS:528:DC%2BD28XntV2rtrY%3D 16814777
43. FB Furnari T Fenton RM Bachoo A Mukasa JM Stommel A Stegh WC Hahn KL Ligon DN Louis C Brennan L Chin RA DePinho WK Cavenee 2007 Malignant astrocytic glioma: genetics, biology, and paths to treatment Genes Dev 21 2683 2710 1:CAS:528:DC%2BD2sXhtlSitLrO 17974913
44. P Garcia-Morales E Carrasco-Garcia P Ruiz-Rico R Martinez-Mira MP Menendez-Gutierrez JA Ferragut M Saceda I Martinez-Lacaci 2007 Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines Oncogene 26 7185 7193 1:CAS:528: DC%2BD2sXht1Oqsb3P 17525741
45. BD Gelb M Tartaglia 2006 Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction Hum Mol Genet 15 Spec. No. 2 R220 R226 1:CAS:528:DC%2BD28XpvFGlsLw%3D 16987887
46. C Giacinti A Giordano 2006 RB and cell cycle progression Oncogene 25 5220 5227 1:CAS:528:DC%2BD28Xos12ntbw%3D 16936740
47. DJ Gough A Corlett K Schlessinger J Wegrzyn AC Larner DE Levy 2009 Mitochondrial STAT3 supports Ras-dependent oncogenic transformation Science 324 1713 1716 1:CAS:528:DC%2BD1MXnsFOmtrY%3D 19556508
48. J Gyuris E Golemis H Chertkov R Brent 1993 Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2 Cell 75 791 803 1:CAS:528:DyaK2cXhtVSnsrs%3D 8242750
49. D Hagerstrand A Smits A Eriksson S Sigurdardottir T Olofsson M Hartman M Nister H Kalimo A Ostman 2008 Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker Neuro Oncol 10 2 9 18003890
50. FG Haj B Markova LD Klaman FD Bohmer BG Neel 2003 Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B J Biol Chem 278 739 744 1:CAS:528:DC%2BD3sXnvVem 12424235
51. M Halle ML Tremblay TC Meng 2007 Protein tyrosine phosphatases: emerging regulators of apoptosis Cell Cycle 6 2773 2781 1:CAS:528:DC%2BD1cXmtFaqtQ%3D%3D 17998804
52. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 57 70 1:CAS:528:DC%2BD3cXks1CktA%3D%3D 10647931
53. GJ Hannon D Casso D Beach 1994 KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases Proc Natl Acad Sci USA 91 1731 1735 1:CAS:528:DyaK2cXis1Cnu7k%3D 8127873
54. WJ Hendriks A Elson S Harroch AW Stoker 2008 Protein tyrosine phosphatases: functional inferences from mouse models and human diseases Febs J 275 816 830 1:CAS:528:DC%2BD1cXivFaqt7Y%3D 18298790
55. JD Henson JA Hannay SW McCarthy JA Royds TR Yeager RA Robinson SB Wharton DA Jellinek SM Arbuckle J Yoo BG Robinson DL Learoyd PD Stalley SF Bonar D Yu RE Pollock RR Reddel 2005 A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas Clin Cancer Res 11 217 225 1:CAS:528:DC%2BD2MXhtVegsLg%3D 15671549
56. AC Hoover GL Strand PN Nowicki ME Anderson PD Vermeer AJ Klingelhutz AD Bossler JV Pottala W Hendriks JH Lee 2009 Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway Oncogene 28 3960 3970 1:CAS:528:DC%2BD1MXhtV2gsb3K 19734941
57. I Hostein D Robertson F DiStefano P Workman PA Clarke 2001 Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin results in cytostasis and apoptosis Cancer Res 61 4003 4009 1:CAS:528:DC%2BD3MXktVWqsbo%3D 11358818
58. JT Huse C Brennan D Hambardzumyan B Wee J Pena SH Rouhanifard C Sohn-Lee C le Sage R Agami T Tuschl EC Holland 2009 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo Genes Dev 23 1327 1337 1:CAS:528:DC%2BD1MXntlegsbc%3D 19487573
59. JT Huse EC Holland 2009 Genetically engineered mouse models of brain cancer and the promise of preclinical testing Brain Pathol 19 132 143 1:CAS:528:DC%2BD1MXitVWht70%3D 19076778
60. MJ Ibarra-Sanchez PD Simoncic FR Nestel P Duplay WS Lapp ML Tremblay 2000 The T-cell protein tyrosine phosphatase Semin Immunol 12 379 386 1:CAS:528:DC%2BD3cXmsFKlsbc%3D 10995584
61. A Idbaih R Carvalho Silva E Criniere Y Marie C Carpentier B Boisselier S Taillibert A Rousseau K Mokhtari F Ducray J Thillet M Sanson K Hoang-Xuan JY Delattre 2008 Genomic changes in progression of low-grade gliomas J Neurooncol 90 133 140 1:CAS:528:DC%2BD1cXhtlamtLzK 18618226
62. VN Ivanov P Lopez Bergami G Maulit TA Sato D Sassoon Z Ronai 2003 FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface Mol Cell Biol 23 3623 3635 1:CAS:528:DC%2BD3sXjs1yht74%3D 12724420
63. H-J Jan C-C Lee Y-M Lin J-H Lai H-W Wei H-M Lee 2009 Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells Cancer Lett 277 141 148 1:CAS:528:DC%2BD1MXjslOktb8%3D 19168281
64. WG Janzarik CP Kratz NT Loges H Olbrich C Klein T Schafer W Scheurlen W Roggendorf C Weiller C Niemeyer R Korinthenberg S Pfister H Omran 2007 Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma Neuropediatrics 38 61 63 1:CAS:528:DC%2BD2sXhtFCgsLrI 17712732
65. J Jemc I Rebay 2007 The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription Annu Rev Biochem 76 513 538 1:CAS:528:DC%2BD2sXhtVehtb%2FF 17341163
66. E Jouanneau 2008 Angiogenesis and gliomas: current issues and development of surrogate markers Neurosurgery 62 31 50 18300890
67. SG Julien N Dube M Read J Penney M Paquet Y Han BP Kennedy WJ Muller ML Tremblay 2007 Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis Nat Genet 39 338 346 1:CAS:528:DC%2BD2sXitVOksbk%3D 17259984
68. B Kaur FW Khwaja EA Severson SL Matheny DJ Brat EG Van Meir 2005 Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis Neuro Oncol 7 134 153 1:CAS:528:DC%2BD2MXjvV2qsLk%3D 15831232
69. MM Keane GA Lowrey SA Ettenberg MA Dayton S Lipkowitz 1996 The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells Cancer Res 56 4236 4243 1:CAS:528:DyaK28XlslGgt7g%3D 8797598
70. M Keniry R Parsons 2008 The role of PTEN signaling perturbations in cancer and in targeted therapy Oncogene 27 5477 5485 1:CAS:528: DC%2BD1cXhtFWiur%2FK 18794882
71. HR Kim CH Lee YH Choi HS Kang HD Kim 1999 Geldanamycin induces cell cycle arrest in K562 erythroleukemic cells IUBMB Life 48 425 428 1:CAS:528: DyaK1MXns1yitL8%3D 10632573
72. S-M Kim J-G Park W-K Baek M-H Suh H Lee SK Yoo K-H Jung S-I Suh B-C Jang 2008 Cadmium specifically induces MKP-1 expression via the glutathione depletion-mediated p38 MAPK activation in C6 glioma cells Neurosci Lett 440 289 293 1:CAS:528:DC%2BD1cXnvVOgtrk%3D 18573614
73. M Klingler-Hoffmann MT Fodero-Tavoletti K Mishima Y Narita WK Cavenee FB Furnari HJ Huang T Tiganis 2001 The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor J Biol Chem 276 46313 46318 1:CAS:528:DC%2BD3MXptVymtb8%3D 11514572
74. JP Knisely JM Baehring 2009 A silver lining on the horizon for glioblastoma Lancet Oncol 10 434 435 19410186
75. L Kong Q Li L Wang Z Liu T Sun 2007 The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas Neuropathology 27 516 521 18021371
76. D Koul 2008 PTEN signaling pathways in glioblastoma Cancer Biol Ther 7 1321 1325 1:CAS:528:DC%2BD1cXhsVKms7%2FJ 18836294
77. M Kovalenko K Denner J Sandstrom C Persson S Gross E Jandt R Vilella F Bohmer A Ostman 2000 Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1 J Biol Chem 275 16219 16226 1:CAS:528:DC%2BD3cXjvFaitLs%3D 10821867
78. N Krishnan DG Jeong SK Jung SE Ryu A Xiao CD Allis SJ Kim NK Tonks 2009 Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent J Biol Chem 284 16066 16070 1:CAS:528:DC%2BD1MXmvFSjsLg%3D 19351884
79. NX Krueger H Saito 1992 A human transmembrane protein-tyrosine- phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases Proc Natl Acad Sci USA 89 7417 7421 1:CAS:528:DyaK3sXhvVCmtQ%3D%3D 1323835
80. S Lamprianou S Harroch 2006 Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system J Mol Neurosci 29 241 255 1:CAS:528:DC%2BD28Xht12hu77L 17085782
81. J Lee S Kotliarova Y Kotliarov A Li Q Su NM Donin S Pastorino BW Purow N Christopher W Zhang JK Park HA Fine 2006 Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines Cancer Cell 9 391 403 1:CAS:528:DC%2BD28XltF2nsLk%3D 16697959
82. F Lefranc J Brotchi R Kiss 2005 Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis J Clin Oncol 23 2411 2422 1:CAS:528:DC%2BD2MXjsVyhsrY%3D 15800333
83. JB Levy PD Canoll O Silvennoinen G Barnea B Morse AM Honegger JT Huang LA Cannizzaro SH Park T Druck, et al. 1993 The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system J Biol Chem 268 10573 10581 1:CAS:528:DyaK3sXks1Kms7g%3D 8387522
84. Y-M Lin H-J Jan C-C Lee H-Y Tao Y-L Shih H-W Wei H-M Lee 2008 Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism Eur J Pharmacol 593 1 9 1:CAS:528:DC%2BD1cXhtVens7bK 18652821
85. ML Loh S Vattikuti S Schubbert MG Reynolds E Carlson KH Lieuw JW Cheng CM Lee D Stokoe JM Bonifas NP Curtiss J Gotlib S Meshinchi MM Le Beau PD Emanuel KM Shannon 2004 Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis Blood 103 2325 2331 1:CAS:528:DC%2BD2cXitlCjsrc%3D 14644997
86. SL Lomonaco S Kahana M Blass Y Brody H Okhrimenko C Xiang S Finniss PM Blumberg HK Lee C Brodie 2008 Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide J Biol Chem 283 17731 17739 1:CAS:528:DC%2BD1cXntFSms78%3D 18434324
87. G Lorente A Nelson S Mueller J Kuo R Urfer K Nikolich ED Foehr 2005 Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment Neuro Oncol 7 154 163 1:CAS:528:DC%2BD2MXjvV2qsLY%3D 15831233
88. DN Louis H Ohgaki OD Wiestler WK Cavenee PC Burger A Jouvet BW Scheithauer P Kleihues 2007 The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol 114 97 109 17618441
89. N Maeda T Nishiwaki T Shintani H Hamanaka M Noda 1996 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) J Biol Chem 271 21446 21452 1:CAS:528:DyaK28XlsVWqtLs%3D 8702927
90. T Maehama JE Dixon 1998 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate J Biol Chem 273 13375 13378 1:CAS:528:DyaK1cXjvVejsLk%3D 9593664
91. S Martinelli C Carta E Flex F Binni EL Cordisco S Moretti E Puxeddu M Tonacchera A Pinchera HP McDowell C Dominici A Rosolen C Di Rocco R Riccardi P Celli M Picardo M Genuardi P Grammatico M Sorcini M Tartaglia 2006 Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors Cancer Genet Cytogenet 166 124 129 1:CAS:528:DC%2BD28XjvVWqt7c%3D 16631468
92. T Marumoto A Tashiro D Friedmann-Morvinski M Scadeng Y Soda FH Gage IM Verma 2009 Development of a novel mouse glioma model using lentiviral vectors Nat Med 15 110 116 1:CAS:528:DC%2BD1MXhtVOqtg%3D%3D 19122659
93. A Massa F Barbieri C Aiello S Arena A Pattarozzi P Pirani A Corsaro R Iuliano A Fusco G Zona R Spaziante T Florio G Schettini 2004 The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation J Biol Chem 279 29004 29012 1:CAS:528:DC%2BD2cXlsVCnt70%3D 15123617
94. A Massa F Barbieri C Aiello R Iuliano S Arena A Pattarozzi A Corsaro V Villa A Fusco G Zona R Spaziante G Schettini T Florio 2004 The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 Ann N Y Acad Sci 1030 264 274 1:CAS:528: DC%2BD2MXivFKkurY%3D 15659806 (Pubitemid 40378922)
95. AJ McIlwrath VG Brunton R Brown 1996 Cell-cycle arrest and p53 accumulation induced by geldanamycin in human ovarian tumour cells Cancer Chemother Pharmacol 37 423 428 1:STN:280:DyaK287ns1yrsQ%3D%3D 8599864
96. K Meng A Rodriguez-Pena T Dimitrov W Chen M Yamin M Noda TF Deuel 2000 Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta Proc Natl Acad Sci USA 97 2603 2608 1:CAS:528:DC%2BD3cXitVaiu7o%3D 10706604
97. C Mikelis E Sfaelou M Koutsioumpa N Kieffer E Papadimitriou 2009 Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta Faseb J 23 1459 1469 1:CAS:528:DC%2BD1MXlsFSms78%3D 19141530
98. A Misra S Ganesh A Shahiwala SP Shah 2003 Drug delivery to the central nervous system: a review J Pharm Pharm Sci 6 252 273 1:CAS:528: DC%2BD3sXnsFenu7s%3D 12935438
99. MG Mohi IR Williams CR Dearolf G Chan JL Kutok S Cohen K Morgan C Boulton H Shigematsu H Keilhack K Akashi DG Gilliland BG Neel 2005 Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations Cancer Cell 7 179 191 1:CAS:528:DC%2BD2MXitFygu7Y%3D 15710330
100. B Mosinger Jr U Tillmann H Westphal ML Tremblay 1992 Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine- phosphatase Proc Natl Acad Sci USA 89 499 503 1:CAS:528:DyaK3sXhvVKlurk%3D 1731319
101. S Muller P Kunkel K Lamszus U Ulbricht GA Lorente AM Nelson D von Schack DJ Chin SC Lohr M Westphal T Melcher 2003 A role for receptor tyrosine phosphatase zeta in glioma cell migration Oncogene 22 6661 6668 14555979
102. MP Myers I Pass IH Batty J Van der Kaay JP Stolarov BA Hemmings MH Wigler CP Downes NK Tonks 1998 The lipid phosphatase activity of PTEN is critical for its tumor supressor function Proc Natl Acad Sci USA 95 13513 13518 1:CAS:528:DyaK1cXnsVGgsL4%3D 9811831
103. MP Myers JP Stolarov C Eng J Li SI Wang MH Wigler R Parsons NK Tonks 1997 P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase Proc Natl Acad Sci USA 94 9052 9057 1:CAS:528:DyaK2sXls1Kmurg%3D 9256433
104. H Nakabayashi M Hara K Shimizu 2006 Prognostic significance of CDC25B expression in gliomas J Clin Pathol 59 725 728 1:CAS:528:DC%2BD28XotFehu7s%3D 16803948
105. R Nishikawa XD Ji RC Harmon CS Lazar GN Gill WK Cavenee HJ Huang 1994 A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity Proc Natl Acad Sci USA 91 7727 7731 1:CAS:528:DyaK2cXltlWhs7w%3D 8052651
106. H Ohgaki P Kleihues 2007 Genetic pathways to primary and secondary glioblastoma Am J Pathol 170 1445 1453 1:CAS:528:DC%2BD2sXlvFCns74%3D 17456751
107. A Ostman C Hellberg FD Bohmer 2006 Protein-tyrosine phosphatases and cancer Nat Rev Cancer 6 307 320 16557282
108. HL Palka M Park NK Tonks 2003 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1 J Biol Chem 278 5728 5735 1:CAS:528:DC%2BD3sXht1aqsb8%3D 12475979
109. A Pandita KD Aldape G Zadeh A Guha CD James 2004 Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR Genes Chromosomes Cancer 39 29 36 1:CAS:528:DC%2BD2cXpsVah 14603439
110. MB Parliament MJ Allalunis-Turner AJ Franko PL Olive R Mandyam C Santos B Wolokoff 2000 Vascular endothelial growth factor expression is independent of hypoxia in human malignant glioma spheroids and tumours Br J Cancer 82 635 641 1:CAS:528:DC%2BD3cXht1eisbw%3D 10682677
111. E Peles J Schlessinger M Grumet 1998 Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling Trends Biochem Sci 23 121 124 1:CAS:528:DyaK1cXivFKmsL8%3D 9584610
112. GJ Pilkington R Bjerkvig L De Ridder P Kaaijk 1997 In vitro and in vivo models for the study of brain tumour invasion Anticancer Res 17 4107 4109 1:STN:280:DyaK1c%2FovF2nsQ%3D%3D 9428342
113. N Pore S Liu DA Haas-Kogan DM O'Rourke A Maity 2003 PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter Cancer Res 63 236 241 1:CAS:528: DC%2BD3sXjvFKntg%3D%3D 12517803
114. M Preusser A Hoischen K Novak T Czech D Prayer JA Hainfellner C Baumgartner FG Woermann IE Tuxhorn HW Pannek M Bergmann B Radlwimmer R Villagran RG Weber VH Hans 2007 Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases Am J Surg Pathol 31 1709 1718 18059228
115. R Pulido R Hooft van Huijsduijnen 2008 Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease Febs J 275 848 866 1:CAS:528:DC%2BD1cXivFaqtL4%3D 18298792
116. SO Rahaman PC Harbor O Chernova GH Barnett MA Vogelbaum SJ Haque 2002 Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells Oncogene 21 8404 8413 1:CAS:528:DC%2BD38Xpt1WitLo%3D 12466961
117. G Ramponi M Stefani 1997 Structural, catalytic, and functional properties of low M(r), phosphotyrosine protein phosphatases. Evidence of a long evolutionary history Int J Biochem Cell Biol 29 279 292 1:CAS:528: DyaK2sXlsVGktbs%3D 9147129
118. W Reichardt V Jung C Brunner A Klein S Wemmert BF Romeike KD Zang S Urbschat 2003 The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas Oncol Rep 10 1275 1279 1:CAS:528:DC%2BD3sXmvFWgurc%3D 12883693
119. F Revillion C Puech F Rabenoelina D Chalbos JP Peyrat G Freiss 2009 Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer Int J Cancer 124 638 643 1:CAS:528:DC%2BD1MXmt1Gguw%3D%3D 19004008
120. J Rudolph 2007 Cdc25 phosphatases: structure, specificity, and mechanism Biochemistry 46 3595 3604 1:CAS:528:DC%2BD2sXitF2htLc%3D 17328562
121. CA Ruivenkamp T van Wezel C Zanon AP Stassen C Vlcek T Csikos AM Klous N Tripodis A Perrakis L Boerrigter PC Groot J Lindeman WJ Mooi GA Meijjer G Scholten H Dauwerse V Paces N van Zandwijk GJ van Ommen P Demant 2002 Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers Nat Genet 31 295 300 1:CAS:528: DC%2BD38XkvVGmt7Y%3D 12089527
122. S Saha A Bardelli P Buckhaults VE Velculescu C Rago B St Croix KE Romans MA Choti C Lengauer KW Kinzler B Vogelstein 2001 A phosphatase associated with metastasis of colorectal cancer Science 294 1343 1346 1:CAS:528: DC%2BD3MXotlKmuro%3D 11598267
123. S Sathornsumetee DA Reardon A Desjardins JA Quinn JJ Vredenburgh JN Rich 2007 Molecularly targeted therapy for malignant glioma Cancer 110 13 24 17520692
124. S Sathornsumetee JN Rich 2008 Designer therapies for glioblastoma multiforme Ann N Y Acad Sci 1142 108 132 1:CAS:528:DC%2BD1cXhsV2hsb7O 18990124
125. M Sato K Takahashi K Nagayama Y Arai N Ito M Okada JD Minna J Yokota T Kohno 2005 Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer Genes Chromosomes Cancer 44 405 414 1:CAS:528:DC%2BD2MXhtFGlsLzJ 16114034
126. M Senju N Sueoka A Sato K Iwanaga Y Sakao S Tomimitsu M Tominaga K Irie S Hayashi E Sueoka 2006 Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines J Cancer Res Clin Oncol 132 150 158 1:CAS:528:DC%2BD2MXhtlGhsLbK 16283383
127. FR Sharp M Bernaudin 2004 HIF1 and oxygen sensing in the brain Nat Rev Neurosci 5 437 448 1:CAS:528:DC%2BD2cXktVyisLw%3D 15152194
128. A Shervington N Cruickshanks H Wright R Atkinson-Dell R Lea G Roberts L Shervington 2006 Glioma: what is the role of c-Myc, hsp90 and telomerase? Mol Cell Biochem 283 1 9 1:CAS:528:DC%2BD28XovVeqtQ%3D%3D 16444580
129. T Shintani M Noda 2008 Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells J Biochem 144 259 266 1:CAS:528:DC%2BD1cXhtVyrsrbN 18477627
130. DA Solomon JS Kim JC Cronin Z Sibenaller T Ryken SA Rosenberg H Ressom W Jean D Bigner H Yan Y Samuels T Waldman 2008 Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma Cancer Res 68 10300 10306 1:CAS:528:DC%2BD1cXhsV2itL%2FO 19074898
131. B Souttou H Juhl J Hackenbruck M Rockseisen HJ Klomp D Raulais M Vigny A Wellstein 1998 Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumors J Natl Cancer Inst 90 1468 1473 1:CAS:528:DyaK1cXmvFalsbc%3D 9776412
132. WC Spanos A Hoover GF Harris S Wu GL Strand ME Anderson AJ Klingelhutz W Hendriks AD Bossler JH Lee 2008 The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth J Virol 82 2493 2500 1:CAS:528:DC%2BD1cXitlyhu78%3D 18160445
133. RL Stallings P Nair JM Maris D Catchpoole M McDermott A O'Meara F Breatnach 2006 High-resolution analysis of chromosomal breakpoints and genomic instability identifies PTPRD as a candidate tumor suppressor gene in neuroblastoma Cancer Res 66 3673 3680 1:CAS:528:DC%2BD28XjtVOrtro%3D 16585193
134. PA Steck MA Pershouse SA Jasser WK Yung H Lin AH Ligon LA Langford ML Baumgard T Hattier T Davis C Frye R Hu B Swedlund DH Teng SV Tavtigian 1997 Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Nat Genet 15 356 362 1:CAS:528:DyaK2sXitF2hs70%3D 9090379
135. AH Stegh S Kesari JE Mahoney HT Jenq KL Forloney A Protopopov DN Louis L Chin RA DePinho 2008 Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma Proc Natl Acad Sci USA 105 10703 10708 1:CAS:528:DC%2BD1cXpvFOjtb0%3D 18669646
136. AH Stegh H Kim RM Bachoo KL Forloney J Zhang H Schulze K Park GJ Hannon J Yuan DN Louis RA DePinho L Chin 2007 Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma Genes Dev 21 98 111 1:CAS:528: DC%2BD2sXmsFyksg%3D%3D 17210792
137. R Stupp ME Hegi WP Mason MJ van den Bent MJ Taphoorn RC Janzer SK Ludwin A Allgeier B Fisher K Belanger P Hau AA Brandes J Gijtenbeek C Marosi CJ Vecht K Mokhtari P Wesseling S Villa E Eisenhauer T Gorlia M Weller D Lacombe JG Cairncross RO Mirimanoff 2009 Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Lancet Oncol 10 459 466 1:CAS:528:DC%2BD1MXlsVKhs74%3D 19269895
138. L Tabernero AR Aricescu EY Jones SE Szedlacsek 2008 Protein tyrosine phosphatases: structure-function relationships Febs J 275 867 882 1:CAS:528:DC%2BD1cXivFaqtL8%3D 18298793
139. T Takahashi K Takahashi PL St John PA Fleming T Tomemori T Watanabe DR Abrahamson CJ Drake T Shirasawa TO Daniel 2003 A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development Mol Cell Biol 23 1817 1831 1:CAS:528:DC%2BD3sXhs1SgsL0%3D 12588999
140. N Tanuma M Nomura M Ikeda I Kasugai Y Tsubaki K Takagaki T Kawamura Y Yamashita I Sato M Sato R Katakura K Kikuchi H Shima 2009 Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion Oncogene 28 752 761 1:CAS:528:DC%2BD1cXhsVeqs7zO 19043453
141. M Tartaglia CM Niemeyer A Fragale X Song J Buechner A Jung K Hahlen H Hasle JD Licht BD Gelb 2003 Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia Nat Genet 34 148 150 1:CAS:528:DC%2BD3sXktFSltrY%3D 12717436
142. M Teodorczyk A Martin-Villalba 2010 Sensing invasion: Cell surface receptors driving spreading of glioblastoma J Cell Physiol 222 1 10 1:CAS:528:DC%2BD1MXhtlGgtrrN 19688773
143. NK Tonks 2006 Protein tyrosine phosphatases: from genes, to function, to disease Nat Rev Mol Cell Biol 7 833 846 1:CAS:528:DC%2BD28XhtFSms77I 17057753
144. F Trapasso A Drusco S Costinean H Alder RI Aqeilan R Iuliano E Gaudio C Raso N Zanesi CM Croce A Fusco 2006 Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis DNA Cell Biol 25 376 382 1:CAS:528:DC%2BD28XmtVarsrY%3D 16792508
145. N Uetani K Kato H Ogura K Mizuno K Kawano K Mikoshiba H Yakura M Asano Y Iwakura 2000 Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice EMBO J 19 2775 2785 1:CAS:528:DC%2BD3cXmtFCru7o%3D 10856223
146. JH Uhm NP Dooley JG Villemure VW Yong 1997 Mechanisms of glioma invasion: role of matrix-metalloproteinases Can J Neurol Sci 24 3 15 1:STN:280: DyaK2s7ps1KmsA%3D%3D 9043741
147. U Ulbricht MA Brockmann A Aigner C Eckerich S Muller R Fillbrandt M Westphal K Lamszus 2003 Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas J Neuropathol Exp Neurol 62 1265 1275 1:CAS:528:DC%2BD2cXht1OnsQ%3D%3D 14692702
148. U Ulbricht C Eckerich R Fillbrandt M Westphal K Lamszus 2006 RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo J Neurochem 98 1497 1506 1:CAS:528:DC%2BD28XhtVymtLnM 16923162
149. S Utsuki Y Sato H Oka B Tsuchiya S Suzuki K Fujii 2002 Relationship between the expression of E-, N-cadherins and beta-catenin and tumor grade in astrocytomas J Neurooncol 57 187 192 12125981
150. S Veeriah C Brennan S Meng B Singh JA Fagin DB Solit PB Paty D Rohle I Vivanco J Chmielecki W Pao M Ladanyi WL Gerald L Liau TC Cloughesy PS Mischel C Sander B Taylor N Schultz J Major A Heguy F Fang IK Mellinghoff TA Chan 2009 The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers Proc Natl Acad Sci USA 106 9435 9440 1:CAS:528:DC%2BD1MXot1Cgu74%3D 19478061
151. I Vivanco N Palaskas C Tran SP Finn G Getz NJ Kennedy J Jiao J Rose W Xie M Loda T Golub IK Mellinghoff RJ Davis H Wu CL Sawyers 2007 Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN Cancer Cell 11 555 569 1:CAS:528:DC%2BD2sXmvVaksrY%3D 17560336
152. B Vogelstein D Lane AJ Levine 2000 Surfing the p53 network Nature 408 307 310 1:CAS:528:DC%2BD3cXosVemtrY%3D 11099028
153. M Wang T Wang S Liu D Yoshida A Teramoto 2003 The expression of matrix metalloproteinase-2 and -9 in human gliomas of different pathological grades Brain Tumor Pathol 20 65 72 14756443
154. Z Wang D Shen DW Parsons A Bardelli J Sager S Szabo J Ptak N Silliman BA Peters MS van der Heijden G Parmigiani H Yan TL Wang G Riggins SM Powell JK Willson S Markowitz KW Kinzler B Vogelstein VE Velculescu 2004 Mutational analysis of the tyrosine phosphatome in colorectal cancers Science 304 1164 1166 1:CAS:528:DC%2BD2cXktVyit7c%3D 15155950
155. J Wegrzyn R Potla YJ Chwae NB Sepuri Q Zhang T Koeck M Derecka K Szczepanek M Szelag A Gornicka A Moh S Moghaddas Q Chen S Bobbili J Cichy J Dulak DP Baker A Wolfman D Stuehr MO Hassan XY Fu N Avadhani JI Drake P Fawcett EJ Lesnefsky AC Larner 2009 Function of mitochondrial Stat3 in cellular respiration Science 323 793 797 1:CAS:528:DC%2BD1MXhtlersbg%3D 19131594
156. CJ Wu DM O'Rourke GS Feng GR Johnson Q Wang MI Greene 2001 The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors Oncogene 20 6018 6025 1:CAS:528: DC%2BD3MXnsVCjsLs%3D 11593409
157. M Yamamoto R Sawaya S Mohanam AK Bindal JM Bruner K Oka VH Rao M Tomonaga GL Nicolson JS Rao 1994 Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo Cancer Res 54 3656 3661 1:CAS:528:DyaK2cXltVGmtrw%3D 8033079 (Pubitemid 24241173)
158. H Yu R Jove 2004 The STATs of cancer: new molecular targets come of age Nat Rev Cancer 4 97 105 1:CAS:528:DC%2BD2cXhtlaqtb0%3D 14964307
159. J Yu S Becka P Zhang X Zhang SM Brady-Kalnay Z Wang 2008 Tumor-derived extracellular mutations of PTPRT/PTPrho are defective in cell adhesion Mol Cancer Res 6 1106 1113 1:CAS:528:DC%2BD1cXoslCgtrw%3D 18644975
160. W Yu I Imoto J Inoue M Onda M Emi J Inazawa 2007 A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity Oncogene 26 1178 1187 1:CAS:528:DC%2BD2sXhvF2ju78%3D 16924234
161. Y Yu X Jiang BS Schoch RS Carroll PM Black MD Johnson 2007 Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma Cancer Res 67 130 138 1:CAS:528:DC%2BD2sXisFSitg%3D%3D 17210692
162. S Zhang ZY Zhang 2007 PTP1B as a drug target: recent developments in PTP1B inhibitor discovery Drug Discov Today 12 373 381 1:CAS:528: DC%2BD2sXkslahsLs%3D 17467573
163. X Zhang A Guo J Yu A Possemato Y Chen W Zheng RD Polakiewicz KW Kinzler B Vogelstein VE Velculescu ZJ Wang 2007 Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T Proc Natl Acad Sci USA 104 4060 4064 1:CAS:528:DC%2BD2sXjt12gtL0%3D 17360477