Inactivation of lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: Adenosylcobalamin destruction and formation of a nucleotide-based radical

Biochemistry

Volumn 49, Issue 7, 2010, Pages 1396-1403

  Lohman, Gregory J S ^a   Gerfen, Gary J ^b   Stubbe, Joanne ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ADENOSYLCOBALAMIN; CLASS II; COFACTORS; COVALENT INTERACTIONS; COVALENTLY BOUND; CYTIDINE; HIGH-FIELD; NMR SPECTROSCOPY; NUCLEOSIDE TRIPHOSPHATES; REACTION MIXTURE; RIBONUCLEOTIDE REDUCTASE; SEPHADEX; SMALL MOLECULES; SUGAR MOIETY; TRIPHOSPHATE;

BIOCHEMISTRY; CENTRIFUGATION; CHROMATOGRAPHIC ANALYSIS; COBALT; FLUORINE COMPOUNDS; HYDROCARBONS; ION EXCHANGE; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; PROTEINS; SUGAR (SUCROSE);

NUCLEOTIDES;

2',2' DIFLUORO 2' DEOXYCYTIDINE 5' TRIPHOSPHATE; BACTERIAL ENZYME; COBALAMIN; COBALT COMPLEX; COBAMAMIDE; CYTIDINE PHOSPHATE; DEOXYCYTIDINE PHOSPHATE; NUCLEOTIDE; RADICAL; RIBONUCLEOTIDE REDUCTASE; TRITIUM; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LACTOBACILLUS LEICHMANNII; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

BACTERIAL PROTEINS; COBAMIDES; CYTIDINE TRIPHOSPHATE; ENZYME ACTIVATION; ENZYME INHIBITORS; FREE RADICALS; LACTOBACILLUS LEICHMANNII; MODELS, CHEMICAL; NUCLEOSIDES; NUCLEOTIDES; RIBONUCLEOTIDE REDUCTASES; RIBOSE;

LACTOBACILLUS LEICHMANNII;

EID: 77449108243     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi9021318     Document Type: Article

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