Radical sites in Mycobacterium tuberculosis KatG identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electron transfer couplings

Journal of Biological Chemistry

Volumn 282, Issue 9, 2007, Pages 6255-6264

  Ranguelova, Kalina ^a   Girotto, Stefania ^a,d   Gerfen, Gary J ^c   Yu, Shengwei ^a   Suarez, Javier ^b   Metlitsky, Leonid ^a   Magliozzo, Richard S ^a,b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CERM Center for Magnetic Resonance   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; COMPUTER SIMULATION; DRUG PRODUCTS; MUTAGENESIS; PARAMAGNETIC RESONANCE;

ANTITUBERCULAR DRUGS; MYCOBACTERIUM TUBERCULOSIS; TRYPTOPHAN RESIDUES; TYROSYL RADICALS;

ENZYME ACTIVITY;

AMINO ACID; BACTERIAL PROTEIN; CATALASE; HEME; ISONIAZID; KATG PROTEIN; MUTANT PROTEIN; PEROXIDASE; PEROXY RADICAL; RADICAL; TRYPTOPHAN; TUBERCULOSTATIC AGENT; TYROSINE; FREE RADICAL; KATG PROTEIN, MYCOBACTERIUM TUBERCULOSIS; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVATION; DRUG BINDING; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME SUBSTRATE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; THREE DIMENSIONAL IMAGING; X RAY ANALYSIS; CATALYSIS; CHEMISTRY; ENZYMOLOGY; INSTRUMENTATION; METABOLISM; METHODOLOGY; TIME;

MYCOBACTERIUM TUBERCULOSIS;

BACTERIAL PROTEINS; CATALASE; CATALYSIS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRON TRANSPORT; FREE RADICALS; MYCOBACTERIUM TUBERCULOSIS; TIME FACTORS; TYROSINE;

EID: 34250328351     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607309200     Document Type: Article

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