Characterization of a substrate-derived radical detected during the inactivation of ribonucleotide reductase from Escherichia coli by 2'- fluoromethylene-2'-deoxycytidine 5'-diphosphate

Journal of the American Chemical Society

Volumn 120, Issue 16, 1998, Pages 3823-3835

  Gerfen, Gary J ^a,b,c   Van Der Donk, Wilfred A ^a,d   Yu, Guixue ^a,e   McCarthy, James R ^f,g   Jarvi, Esa T ^g   Matthews, Donald P ^g   Farrar, Christian ^a,b   Griffin, Robert G ^a,b   Stubbe, JoAnne ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e CUBIST PHARMACEUTICALS INC   (United States)

^f NEUROCRINE BIOSCIENCES INC   (United States)

^g Merrell Dow Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' FLUOROMETHYLENE 2' DEOXYCYTIDINE 5' DIPHOSPHATE; ANTINEOPLASTIC AGENT; RIBONUCLEOTIDE REDUCTASE; TEZACITABINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; REACTION ANALYSIS;

EID: 0032577017     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja972166e     Document Type: Article

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