Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: Evidence for thiyl radical-mediated nucleotide radical formation

Biochemistry

Volumn 37, Issue 16, 1998, Pages 5528-5535

  Silva, Domingos J ^a   Stubbe, JoAnne ^a   Samano, Vicente ^b   Robins, Morris J ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; COBALAMIN; COBAMAMIDE; CYSTEINE; CYTIDINE TRIPHOSPHATE; DEOXYADENOSINE; FLUORIDE ION; GEMCITABINE 5' TRIPHOSPHATE; NUCLEOSIDE TRIPHOSPHATE; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; PROTEINASE; RADICAL; RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE; THIYL RADICAL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; LACTOBACILLUS; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY;

CYTOSINE; DEOXYADENOSINES; DEOXYCYTIDINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; FLUORIDES; FREE RADICALS; LACTOBACILLUS; PEPTIDES; PROTEIN DENATURATION; RIBONUCLEOTIDE REDUCTASES; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFHYDRYL COMPOUNDS; VITAMIN B 12;

EID: 0032554617     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972934e     Document Type: Article

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