Inactivation of lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro2'-deoxycytidine s'-triphosphate: Covalent modification

Biochemistry

Volumn 49, Issue 7, 2010, Pages 1404-1417

  Lohman, Gregory J S ^a   Stubbe, Joanne ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLCOBALAMIN; C-TERMINUS; CLASS I; COFACTORS; COMMON FEATURES; COVALENT MODIFICATIONS; COVALENTLY BOUND; FURANONES; HPLC SEPARATION; ISOLATION AND IDENTIFICATION; LABELED PROTEINS; MALDI-TOF MASS SPECTROMETRY; MULTIPLE REACTION PATHWAYS; NUCLEOSIDE TRIPHOSPHATES; RIBONUCLEOTIDE REDUCTASE; SDS-PAGE; SEPHADEX; TRIPHOSPHATE; TRYPSIN DIGESTION;

CHROMATOGRAPHIC ANALYSIS; HYDROCARBONS; ION EXCHANGE; MASS SPECTROMETRY; PEPTIDES;

SUGAR (SUCROSE);

2',2' DIFLUORO 2' DEOXYCYTIDINE 5' TRIPHOSPHATE; CYTIDINE PHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEUTERIUM; GEMCITABINE; NUCLEOSIDE; RIBONUCLEOTIDE REDUCTASE; TRITIUM; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LACTOBACILLUS LEICHMANNII; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SYNTHESIS;

ALKYLATION; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; COBAMIDES; CYTIDINE TRIPHOSPHATE; CYTOSINE DEAMINASE; ENZYME INHIBITORS; HUMANS; LACTOBACILLUS LEICHMANNII; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RIBONUCLEOTIDE REDUCTASES; TANDEM MASS SPECTROMETRY;

LACTOBACILLUS LEICHMANNII;

EID: 77449122240     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi902132u     Document Type: Article

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