Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis

Journal of Neuroscience

Volumn 24, Issue 36, 2004, Pages 7945-7950

  Kiaei, Mahmoud ^a,c   Bush, Ashley I ^b,d   Morrison, Brett M ^c   Morrison, John H ^c   Cherny, Robert A ^d   Volitakis, Irene ^d   Beal, M Flint ^a   Gordon, Jon W ^c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Amyotrophic lateral sclerosis; Copper; Motor neuron; Mottled brindled; Neurodegeneration; Superoxide dismutase

Indexed keywords

COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; COPPER ZINC SUPEROXIDE DISMUTASE 1; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ALLELE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPPER DEFICIENCY; COPPER ZINC SUPEROXIDE DISMUTASE GENE; ENZYME ACTIVE SITE; FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS; FAMILIAL DISEASE; FEMALE; GAIN OF FUNCTION MUTATION; GENE; GENE FUNCTION; GENE MUTATION; GENETIC DISORDER; LONGEVITY; MALE; MOBR GENE; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; TRANSGENIC MOUSE; X CHROMOSOME LINKED DISORDER;

ADENOSINE TRIPHOSPHATASES; ALLELES; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; BRAIN CHEMISTRY; CATION TRANSPORT PROTEINS; COPPER; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; FEMALE; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; PHENOTYPE; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 4544377971     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2000-04.2004     Document Type: Article

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