The specific JNK inhibitor SP600125 targets tumour necrosis factor-α production and epithelial cell apoptosis in acute murine colitis

Immunology

Volumn 118, Issue 1, 2006, Pages 112-121

  Assi, Kiran ^a   Pillai, Rex ^a   Gómez Muñoz, Antonio ^b,c   Owen, David ^b   Salh, Baljinder ^a,d  

^a JACK BELL RESEARCH CENTRE   (Canada)

^b VANCOUVER HOSPITAL AND HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cytokines; Dextran sulphate sodium; Inflammatory bowel disease; Mitogen activated protein kinase; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CD28 ANTIGEN; CD3 ANTIGEN; DEXTRAN SULFATE; DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; COLITIS; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DNA BINDING; DRUG SPECIFICITY; DRUG TARGETING; EPITHELIUM CELL; HISTOLOGY; IMMUNOFLUORESCENCE; INFLAMMATORY CELL; LYMPHOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SCORING SYSTEM; SIGNAL TRANSDUCTION; STIMULATION;

ANIMALS; ANTHRACENES; APOPTOSIS; BLOTTING, WESTERN; COLITIS, ULCERATIVE; COLON; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; INTESTINAL MUCOSA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 33645828828     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02349.x     Document Type: Article

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