-
1
-
-
18044391665
-
Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-current status and future prospects
-
Kelland LR. Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-current status and future prospects. Eur J Cancer 2005;41:971-9.
-
(2005)
Eur J Cancer
, vol.41
, pp. 971-979
-
-
Kelland, L.R.1
-
2
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995;269:1236-41.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
-
3
-
-
0030938901
-
Reverse transcriptase motifs in the catalytic subunit of telomerase
-
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 1997;276:561-7.
-
(1997)
Science
, vol.276
, pp. 561-567
-
-
Lingner, J.1
Hughes, T.R.2
Shevchenko, A.3
Mann, M.4
Lundblad, V.5
Cech, T.R.6
-
4
-
-
0037987939
-
Telomerase and tumorigenesis
-
Masutomi K, Hahn WC. Telomerase and tumorigenesis. Cancer Lett 2003;194:163-72.
-
(2003)
Cancer Lett
, vol.194
, pp. 163-172
-
-
Masutomi, K.1
Hahn, W.C.2
-
5
-
-
0033558281
-
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
-
Horikawa I, Cable PL, Afshari C, Barrett JC. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res 1999;59:826-30.
-
(1999)
Cancer Res
, vol.59
, pp. 826-830
-
-
Horikawa, I.1
Cable, P.L.2
Afshari, C.3
Barrett, J.C.4
-
6
-
-
0033082526
-
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
-
Takakura M, Kyo S, Kanaya T, et al. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 1999;59:551-7.
-
(1999)
Cancer Res
, vol.59
, pp. 551-557
-
-
Takakura, M.1
Kyo, S.2
Kanaya, T.3
-
7
-
-
0033577876
-
Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
-
Wick M, Zubov D, Hagen G. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 1999;232:97-106.
-
(1999)
Gene
, vol.232
, pp. 97-106
-
-
Wick, M.1
Zubov, D.2
Hagen, G.3
-
8
-
-
0037223887
-
Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter
-
Renaud S, Bosman FT, Benhattar J. Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter. Biochem Biophys Res Commun 2003;300:47-54.
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 47-54
-
-
Renaud, S.1
Bosman, F.T.2
Benhattar, J.3
-
9
-
-
0034142386
-
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
-
Kyo S, Takakura M, Taira T, et al. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res 2000;28:669-77.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 669-677
-
-
Kyo, S.1
Takakura, M.2
Taira, T.3
-
10
-
-
0034107095
-
Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells
-
Misiti S, Nanni S, Fontemaggi G, et al. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol 2000;20:3764-71.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3764-3771
-
-
Misiti, S.1
Nanni, S.2
Fontemaggi, G.3
-
11
-
-
0035394055
-
E2F-1 represses transcription of the human telomerase reverse transcriptase gene
-
Crowe DL, Nguyen DC, Tsang KJ, Kyo S. E2F-1 represses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res 2001;29:2789-94.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2789-2794
-
-
Crowe, D.L.1
Nguyen, D.C.2
Tsang, K.J.3
Kyo, S.4
-
12
-
-
0033601234
-
The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene
-
Oh S, Song Y, Yim J, Kim TK. The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene. J Biol Chem 1999;274:37473-8.
-
(1999)
J Biol Chem
, vol.274
, pp. 37473-37478
-
-
Oh, S.1
Song, Y.2
Yim, J.3
Kim, T.K.4
-
13
-
-
0034234575
-
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: Possible role of MZF-2 in transcriptional repression of hTERT
-
Fujimoto K, Kyo S, Takakura M, et al. Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT. Nucleic Acids Res 2000;28:2557-62.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 2557-2562
-
-
Fujimoto, K.1
Kyo, S.2
Takakura, M.3
-
14
-
-
0037082423
-
Natural and pharmacological regulation of telomerase
-
Mergny JL, Riou JF, Mailliet P, Teulade-Fichou MP, Gilson E. Natural and pharmacological regulation of telomerase. Nucleic Acids Res 2002;30:839-65.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 839-865
-
-
Mergny, J.L.1
Riou, J.F.2
Mailliet, P.3
Teulade-Fichou, M.P.4
Gilson, E.5
-
15
-
-
32544444844
-
Telomeres and telomerase as targets for anticancer drug development
-
Olaussen KA, Dubrana K, Domont J, Spano JP, Sabatier L, Soria JC. Telomeres and telomerase as targets for anticancer drug development. Crit Rev Oncol Hematol 2006;57:191-214.
-
(2006)
Crit Rev Oncol Hematol
, vol.57
, pp. 191-214
-
-
Olaussen, K.A.1
Dubrana, K.2
Domont, J.3
Spano, J.P.4
Sabatier, L.5
Soria, J.C.6
-
16
-
-
32044458625
-
Designer zinc-finger proteins and their applications
-
Papworth M, Kolasinska P, Minczuk M. Designer zinc-finger proteins and their applications. Gene 2006;366:27-38.
-
(2006)
Gene
, vol.366
, pp. 27-38
-
-
Papworth, M.1
Kolasinska, P.2
Minczuk, M.3
-
17
-
-
0031053362
-
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
-
Greisman HA, Pabo CO. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 1997;275: 657-61.
-
(1997)
Science
, vol.275
, pp. 657-661
-
-
Greisman, H.A.1
Pabo, C.O.2
-
18
-
-
0032981699
-
Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences
-
Segal DJ, Dreier B, Beerli RR, Barbas CF III. Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences. Proc Natl Acad Sci U S A 1999;96:2758-63.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 2758-2763
-
-
Segal, D.J.1
Dreier, B.2
Beerli, R.R.3
Barbas III, C.F.4
-
19
-
-
0030903688
-
Design of polydactyl zincfinger proteins for unique addressing within complex genomes
-
Liu Q, Segal DJ, Ghiara JB, Barbas CF III. Design of polydactyl zincfinger proteins for unique addressing within complex genomes. Proc Natl Acad Sci U S A 1997;94:5525-30.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 5525-5530
-
-
Liu, Q.1
Segal, D.J.2
Ghiara, J.B.3
Barbas III, C.F.4
-
20
-
-
0034652141
-
Positive and negative regulation of endogenous genes by designed transcription factors
-
Beerli RR, Dreier B, Barbas CF III. Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci U S A 2000;97:1495-500.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1495-1500
-
-
Beerli, R.R.1
Dreier, B.2
Barbas III, C.F.3
-
21
-
-
4344685148
-
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation
-
Magnenat L, Blancafort P, Barbas CF III. In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation. J Mol Biol 2004;341:635-49.
-
(2004)
J Mol Biol
, vol.341
, pp. 635-649
-
-
Magnenat, L.1
Blancafort, P.2
Barbas III, C.F.3
-
22
-
-
26444464763
-
Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: Insights into ErbB receptor biology
-
Lund CV, Popkov M, Magnenat L, Barbas CF III. Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology. Mol Cell Biol 2005;25:9082-91.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9082-9091
-
-
Lund, C.V.1
Popkov, M.2
Magnenat, L.3
Barbas III, C.F.4
-
23
-
-
33644774584
-
Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site
-
Eberhardy SR, Goncalves J, Coelho S, et al. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol 2006;80:2873-83.
-
(2006)
J Virol
, vol.80
, pp. 2873-2883
-
-
Eberhardy, S.R.1
Goncalves, J.2
Coelho, S.3
-
24
-
-
65749115965
-
Zinc-finger-based artificial transcription factors and their applications
-
Sera T. Zinc-finger-based artificial transcription factors and their applications. Adv Drug Deliver Rev 2009;61:513-26.
-
(2009)
Adv Drug Deliver Rev
, vol.61
, pp. 513-526
-
-
Sera, T.1
-
25
-
-
0037335514
-
Human zinc fingers as building blocks in the construction of artificial transcription factors
-
Bae KH, Kwon YD, Shin HC, et al. Human zinc fingers as building blocks in the construction of artificial transcription factors. Nat Biotechnol 2003;21:275-80.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 275-280
-
-
Bae, K.H.1
Kwon, Y.D.2
Shin, H.C.3
-
26
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-5.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
-
27
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
-
(1997)
Eur J Cancer
, vol.33
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
29
-
-
0038701811
-
Telomerase inhibition as cancer therapy
-
Saretzki G. Telomerase inhibition as cancer therapy. Cancer Lett 2003;194:209-19.
-
(2003)
Cancer Lett
, vol.194
, pp. 209-219
-
-
Saretzki, G.1
-
30
-
-
39749163359
-
Telomerase and cancer therapeutics
-
Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer 2008;8:167-79.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 167-179
-
-
Harley, C.B.1
-
31
-
-
39449092745
-
Targeting telomerase for cancer therapeutics
-
Shay JW, Keith WN. Targeting telomerase for cancer therapeutics. Br J Cancer 2008;98:677-83.
-
(2008)
Br J Cancer
, vol.98
, pp. 677-683
-
-
Shay, J.W.1
Keith, W.N.2
-
32
-
-
0032539902
-
Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants
-
Kim JS, Pabo CO. Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc Natl Acad Sci U S A 1998;95:2812-7.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 2812-2817
-
-
Kim, J.S.1
Pabo, C.O.2
-
33
-
-
27244436299
-
Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels
-
Kwon HS, Shin HC, Kim JS. Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels. Nucleic Acids Res 2005;33:e74.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Kwon, H.S.1
Shin, H.C.2
Kim, J.S.3
-
34
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔ C(T)) method
-
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔ C(T)) method. Methods 2001;25:402-8.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
35
-
-
34247492871
-
Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors
-
Beltran A, Parikh S, Liu Y, et al. Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors. Oncogene 2007;26:2791-8.
-
(2007)
Oncogene
, vol.26
, pp. 2791-2798
-
-
Beltran, A.1
Parikh, S.2
Liu, Y.3
-
36
-
-
48449099915
-
Reprograming epigenetic silencing: Artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor
-
Beltran AS, Sun X, Lizardi PM, Blancafort P. Reprograming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor. Mol Cancer Ther 2008;7:1080-90.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1080-1090
-
-
Beltran, A.S.1
Sun, X.2
Lizardi, P.M.3
Blancafort, P.4
-
37
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-52.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
38
-
-
0037459039
-
Immortalization with telomerase of the Nestin-positive cells of the human pancreas
-
Lee KM, Nguyen C, Ulrich AB, Pour PM, Ouellette MM. Immortalization with telomerase of the Nestin-positive cells of the human pancreas. Biochem Biophys Res Commun 2003;301:1038-44.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 1038-1044
-
-
Lee, K.M.1
Nguyen, C.2
Ulrich, A.B.3
Pour, P.M.4
Ouellette, M.M.5
-
39
-
-
0142155259
-
Biological applications of protein transduction technology
-
Kabouridis PS. Biological applications of protein transduction technology. Trends Biotechnol 2003;21:498-503.
-
(2003)
Trends Biotechnol
, vol.21
, pp. 498-503
-
-
Kabouridis, P.S.1
-
40
-
-
52649143305
-
Transduction of artificial transcriptional regulatory proteins into human cells
-
Yun CO, Shin HC, Kim TD, et al. Transduction of artificial transcriptional regulatory proteins into human cells. Nucleic Acids Res 2008;36:e103.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Yun, C.O.1
Shin, H.C.2
Kim, T.D.3
|