Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter

Biochemical and Biophysical Research Communications

Volumn 300, Issue 1, 2003, Pages 47-54

  Renaud, Stéphanie ^a   Bosman, Fred T ^a   Benhattar, Jean ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

hTERT; Promoter; Repressor; Splicing; Telomerase; Transient transfection

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA VECTOR; EXON; GENE ACTIVITY; GENE SILENCING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; PROMOTER REGION; RNA SPLICING; TRANSCRIPTION REGULATION;

CODON, INITIATOR; DNA-BINDING PROTEINS; DOWN-REGULATION; EXONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; PROMOTER REGIONS (GENETICS); READING FRAMES; RNA SPLICING; TELOMERASE; TRANSFECTION;

EID: 0037223887     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02775-4     Document Type: Article

References (35)

1. C.W. Greider, Telomere length regulation, Annu. Rev. Biochem. 65 (1996) 337-365.
2. C.W. Greider, Chromosome first aid, Cell 67 (1991) 645-647.
3. R.C. Allsopp, H. Vaziri, C. Patterson, S. Goldstein, E.V. Younglai, A.B. Futcher, C.W. Greider, C.B. Harley, Telomere length predicts replicative capacity of human fibroblasts, Proc. Natl. Acad. Sci. USA 89 (1992) 10114-10118.
4. W.E. Wright, M.A. Piatyszek, W.E. Rainey, W. Byrd, J.W. Shay, Telomerase activity in human germline and embryonic tissues and cells, Dev. Genet. 18 (1996) 173-179.
5. S. Yasumoto, C. Kunimura, K. Kikuchi, H. Tahara, H. Ohji, H. Yamamoto, T. Ide, T. Utakoji, Telomerase activity in normal human epithelial cells, Oncogene 13 (1996) 433-439.
6. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L. Ho, G.M. Coviello, W.E. Wright, S.L. Weinrich, J.W. Shay, Specific association of human telomerase activity with immortal cells and cancer, Science 266 (1994) 2011-2015.
7. J. Feng, W.D. Funk, S.S. Wang, S.L. Weinrich, A.A. Avilion, C.P. Chiu, R.R. Adams, E. Chang, R.C. Allsopp, J. Yu, The RNA component of human telomerase, Science 269 (1995) 1236-1241.
8. L. Harrington, T. McPhail, V. Mar, W. Zhou, R. Oulton, M.B. Bass, I. Arruda, M.O. Robinson, A mammalian telomerase-associated protein, Science 275 (1997) 973-977.
9. T.L. Beattie, W. Zhou, M.O. Robinson, L. Harrington, Reconstitution of human telomerase activity in vitro, Curr. Biol. 8 (1998) 177-180.
10. K. Collins, R. Kobayashi, C.W. Greider, Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme, Cell 81 (1995) 677-686.
11. J. Nakayama, M. Saito, H. Nakamura, A. Matsuura, F. Ishikawa, TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family, Cell 88 (1997) 875-884.
12. A. Kilian, D.D. Bowtell, H.E. Abud, G.R. Hime, D.J. Venter, P.K. Keese, E.L. Duncan, R.R. Reddel, R.A. Jefferson, Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types, Hum. Mol. Genet. 6 (1997) 2011-2019.
13. M. Meyerson, C.M. Counter, E.N. Eaton, L.W. Ellisen, P. Steiner, S.D. Caddle, L. Ziaugra, R.L. Beijersbergen, M.J. Davidoff, Q. Liu, S. Bacchetti, D.A. Haber, R.A. Weinberg, hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization, Cell 90 (1997) 785-795.
14. A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, W.E. Wright, Extension of life-span by introduction of telomerase into normal human cells, Science 279 (1998) 349-352.
15. C.M. Counter, M. Meyerson, E.N. Eaton, L.W. Ellisen, S.D. Caddle, D.A. Haber, R.A. Weinberg, Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase, Oncogene 16 (1998) 1217-1222.
16. S.L. Weinrich, R. Pruzan, L. Ma, M. Ouellette, V.M. Tesmer, S.E. Holt, A.G. Bodnar, S. Lichtsteiner, N.W. Kim, J.B. Trager, R.D. Taylor, R. Carlos, W.H. Andrews, W.E. Wright, J.W. Shay, C.B. Harley, G.B. Morin, Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT, Nat. Genet. 17 (1997) 498-502.
17. I. Horikawa, P.L. Cable, C. Afshari, J.C. Barrett, Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene, Cancer Res. 59 (1999) 826-830.
18. M. Takakura, S. Kyo, T. Kanaya, H. Hirano, J. Takeda, M. Yutsudo, M. Inoue, Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells, Cancer Res. 59 (1999) 551-557.
19. M. Wick, D. Zubov, G. Hagen, Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT), Gene 232 (1999) 97-106.
20. S. Kyo, M. Takakura, T. Taira, T. Kanaya, H. Itoh, M. Yutsudo, H. Ariga, M. Inoue, Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT), Nucleic Acids Res. 28 (2000) 669-677.
21. K.J. Wu, C. Grandori, M. Amacker, N. Simon-Vermot, A. Polack, J. Lingner, R. Dalla-Favera, Direct activation of TERT transcription by c-MYC, Nat. Genet. 21 (1999) 220-224.
22. S. Misiti, S. Nanni, G. Fontemaggi, Y.S. Cong, J. Wen, H.W. Hirte, G. Piaggio, A. Sacchi, A. Pontecorvi, S. Bacchetti, A. Farsetti, Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells, Mol. Cell. Biol. 20 (2000) 3764-3771.
23. S. Oh, Y. Song, J. Yim, T.K. Kim, The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene, J. Biol.Chem. 274 (1999) 37473-37478.
24. H. Li, Y. Cao, M.C. Berndt, J.W. Funder, J.P. Liu, Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro, Oncogene 18 (1999) 6785-6794.
25. D. Xu, Q. Wang, A. Gruber, M. Bjorkholm, Z. Chen, A. Zaid, G. Selivanova, C. Peterson, K.G. Wiman, P. Pisa, Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells, Oncogene 19 (2000) 5123-5133.
26. K. Fujimoto, S. Kyo, M. Takakura, T. Kanaya, Y. Kitagawa, H. Itoh, M. Takahashi, M. Inoue, Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: Possible role of MZF-2 in transcriptional repression of hTERT, Nucleic Acids Res. 28 (2000) 2557-2562.
27. C. Gunes, S. Lichtsteiner, A.P. Vasserot, C. Englert, Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1, Cancer Res. 60 (2000) 2116-2121.
28. D. Xu, N. Popov, M. Hou, Q. Wang, M. Bjorkholm, A. Gruber, A.R. Menkel, M. Henriksson, Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells, Proc. Natl. Acad. Sci. USA 98 (2001) 3826-3831.
29. A.L. Ducrest, M. Amacker, Y.D. Mathieu, A.P. Cuthbert, D.A. Trott, R.F. Newbold, M. Nabholz, J. Lingner, Regulation of human telomerase activity: R epression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity, Cancer Res. 61 (2001) 7594-7602.
30. G.A. Ulaner, J.F. Hu, T.H. Vu, L.C. Giudice, A.R. HoLman, Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts, Cancer Res. 58 (1998) 4168-4172.
31. Y.S. Cong, J. Wen, S. Bacchetti, The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter, Hum. Mol. Genet. 8 (1999) 137-142.
32. A. Gavalas, H. Zalkin, Analysis of the chicken GPAT/AIRC bidirectional promoter for de novo purine nucleotide synthesis, J. Biol. Chem. 270 (1995) 2403-2410.
33. G.A. Ulaner, J.F. Hu, T.H. Vu, L.C. Giudice, A.R. Hoffman, Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development, Int. J. Cancer 91 (2001) 644-649.
34. X. Yi, J.W. Shay, W.E. Wright, Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells, Nucleic Acids Res. 29 (2001) 4818-4825.
35. M. Kozak, Initiation of translation in prokaryotes and eukaryotes, Gene 234 (1999) 187-208.