Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels

Nucleic Acids Research

Volumn 33, Issue 8, 2005, Pages 1-10

  Kwon, Heung Sun ^a   Shin, Hyun Chul ^a   Kim, Jin Soo ^a  

^a ToolGen Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MESSENGER RNA; OXYGEN; SMALL INTERFERING RNA; VASCULOTROPIN A; ZINC FINGER PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CANCER; CELL CULTURE; CELL GROWTH; CELL STIMULATION; CELL STRAIN HEK293; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ASSAY; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HYPOXIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; REPORTER GENE; BIOSYNTHESIS; CELL HYPOXIA; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; RNA INTERFERENCE;

CELL HYPOXIA; CELL LINE; GENE SILENCING; GENES, REPORTER; HUMANS; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; ZINC FINGERS;

EID: 27244436299     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gni068     Document Type: Article

References (45)

1. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806-811.
2. Hammond, S.M., Boettcher, S., Caudy, A.A., Kobayashi, R. and Hannon, G.J. (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science, 293, 1146-1150.
3. Gonczy, P., Echeverri, C., Oegema, K., Coulson, A., Jones, S.J., Copley, R.R., Duperon, J., Oegema, J., Brehm, M., Cassin, E. et al. (2000) Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature, 408, 331-336.
4. Simmer, F., Moorman, C., Van Der Linden, A.M., Kuijk, E., Van Den Berghe, P.V., Kamath, R., Fraser, A.G., Ahringer, J. and Plasterk, R.H. (2003) Genome-wide RNAi of C. elegans Using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol., 1, E12.
5. Kennerdell, J.R. and Carthew, R.W. (2000) Heritable gene silencing in Drosophila using double-stranded RNA. Nat. Biotechnol., 18, 896-898.
6. Voinnet, O. (2001) RNA silencing as a plant immune system against viruses. Trends Genet., 17, 449-459.
7. Waterhouse, P.M., Graham, M.W. and Wang, M.B. (1998) Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA. Proc. Natl Acad. Sci. USA, 95, 13959-13964.
8. Svoboda, P., Stein, P., Hayashi, H. and Schultz, R.M. (2000) Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development, 127, 4147-4156.
9. Svoboda, P., Stein, P. and Schultz, R.M. (2001) RNAi in mouse oocytes and preimplantation embryos: Effectiveness of hairpin dsRNA. Biochem. Biophys. Res. Commun., 287, 1099-1104.
10. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411, 494-498.
11. Mette, M.F., Aufsatz, W., van der Winden, J., Matzke, M.A. and Matzke, A.J. (2000) Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J., 19, 5194-5201.
12. Jones, L., Ratcliff, F. and Baulcombe, D.C. (2001) RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance. Curr. Biol., 11, 747-757.
13. Wassenegger, M., Heimes, S., Riedel, L. and Sanger, H.L. (1994) RNA-directed de novo methylation of genomic sequences in plants. Cell, 76, 567-576.
14. Pal-Bhadra, M., Bhadra, U. and Birchler, J.A. (2002) RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol. Cell., 9, 315-327.
15. Chi, J.T., Chang, H.Y., Wang, N.N., Chang, D.S., Dunphy, N. and Brown, P.O. (2003) Genomewide view of gene silencing by small interfering RNAs. Proc. Natl Acad. Sci. USA, 100, 6343-6346.
16. Zhang, L., Yang, N., Mohamed-Hadley, A., Rubin, S.C. and Coukos, G. (2003) Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer. Biochem. Biophys. Res. Commun., 303, 1169-1178.
17. Nardelli, J., Gibson, T.J., Vesque, C. and Charnay, P. (1991) Base sequence discrimination by zinc-finger DNA-binding domains. Nature, 349, 175-178.
18. Desjarlais, J.R. and Berg, J.M. (1993) Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins. Proc. Natl Acad. Sci. USA, 90, 2256-2260.
19. Greisman, H.A. and Pabo, C.O. (1997) A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science, 275, 657-661.
20. Segal, D.J., Dreier, B., Beerli, R.R. and Barbas, C.F., III (1999) Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences. Proc. Natl Acad. Sci. USA, 96, 2758-2763.
21. Choo, Y. and Klug, A. (1994) Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions. Proc. Natl Acad. Sci. USA, 91, 11168-11172.
22. Bae, K.H., Kwon, Y.D., Shin, H.C., Hwang, M.S., Ryu, E.H., Park, K.S., Yang, H.Y., Lee, D.K., Lee, Y., Park, J. et al. (2003) Human zinc fingers as building blocks in the construction of artificial transcription factors. Nat. Biotechnol., 21, 275-280.
23. Liu, P.Q., Rebar, E.J., Zhang, L., Liu, Q., Jamieson, A.C., Liang, Y., Qi, H., Li, P.X., Chen, B., Mendel, M.C. et al. (2001) Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J. Biol. Chem., 276, 11323-11334.
24. Zhang, L., Spratt, S.K., Liu, Q., Johnstone, B., Qi, H., Raschke, E.E., Jamieson, A.C., Rebar, E.J., Wolffe, A.P. and Case, C.C. (2000) Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene. J. Biol. Chem. 275, 33850-33860.
25. Rebar, E.J., Huang, Y., Hickey, R., Nath, A.K., Meoli, D., Nath, S., Chen, B., Xu, L., Liang, Y., Jamieson, A.C. et al. (2002) Induction of angiogenesis in a mouse model using engineered transcription factors. Nature Med., 8, 1427-1432.
26. Jouvenot, Y., Ginjala, V., Zhang, L., Liu, P.Q., Oshimura, M., Feinberg, A.P., Wolffe, A.P., Ohlsson, R. and Gregory, P.D. (2003) Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors. Gene Ther., 10, 513-522.
27. Guan, X., Stege, J., Kim, M., Dahmani, Z., Fan, N., Heifetz, P., Barbas, C.F.,III and Briggs, S.P. (2002) Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc Natl Acad. Sci. USA, 99, 13296-13301.
28. Park, K.S., Lee, D.K., Lee, H., Lee, Y., Jang, Y.S., Kim, Y.H., Yang, H.Y., Lee, S.I., Seol, W. and Kim, J.S. (2003) Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors. Nat. Biotechnol., 21, 1208-1214.
29. Blancafort, P., Magnenat, L. and Barbas, C.F., III (2003) Scanning the human genome with combinatorial transcription factor libraries. Nat. Biotechnol., 21, 269-274.
30. Kim, J.S. and Pabo, C.O. (1997) Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy. J. Biol. Chem., 272, 29795-29800.
31. Snowden, A.W., Zhang, L., Urnov, F., Dent, C., Jouvenot, Y., Zhong, X., Rebar, E.J., Jamieson, A.C., Zhang, H.S., Tan, S. et al. (2003) Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. Cancer Res., 63, 8968-8976.
32. Tan, S., Guschin, D., Davalos, A., Lee, Y.L., Snowden, A.W., Jouvenot, Y., Zhang, H.S., Howes, K., McNamara, A.R., Lai, A. et al. (2003) Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity. Proc. Natl Acad. Sci. USA, 100, 11997-12002.
33. Lee, D.K., Park, J.W., Kim, Y.J., Kim, J., Lee, Y., Kim, J. and Kim, J.S. (2003) Toward a functional annotation of the human genome using artificial transcription factors. Genome Res., 13, 2708-2716.
34. Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W.S. and Khvorova, A. (2004) Rational siRNA design for RNA interference. Nat. Biotechnol., 22, 326-330.
35. Clemens, J.C., Worby, C.A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B.A. and Dixon, J.E. (2000) Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl Acad. Sci. USA, 97, 6499-6503.
36. Jacque, J.M., Triques, K. and Stevenson, M. (2002) Modulation of HIV-1 replication by RNA interference. Nature, 418, 435-438.
37. Beerli, R.R., Dreier, B. and Barbas, C.F., III (2000) Positive and negative regulation of endogenous genes by designed transcription factors. Proc. Natl Acad. Sci. USA, 97, 1495-1500.
38. Bartsevich, V.V., Miller, J.C., Case, C.C. and Pabo, C.O. (2003) Engineered zinc finger proteins for controlling stem cell fate. Stem Cells, 21, 632-637.
39. Reynolds, L., Ullman, C., Moore, M., Isalan, M., West, M.J., Clapham, P., Klug, A. and Choo, Y. (2003) Repression of the HIV-1 5′ LTR promoter and inhibition of HTV-1 replication by using engineered zinc-finger transcription factors. Proc. Natl Acad. Sci. USA 100, 1615-1620.
40. Graslund, T., Li, X., Magnenat, L., Popkov, M. and Barbas, C.F., III (2005) Exploring strategies for the design of artificial transcription factors: Targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease. J. Biol. Chem., 280, 3707-3714.
41. Libri, V., Onori, A., Fanciulli, M., Passananti, C. and Corbi,N. (2004) The artificial zinc finger protein 'Blues' binds the enhancer of the fibroblast growth factor 4 and represses transcription. FEBS Lett., 560, 75-80.
42. Corbi, N., Libri, V., Fanciulli, M., Tinsley, J.M., Davies, K.E. and Passananti, C. (2000) The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription. Gene Ther., 7, 1076-1083.
43. Gao, G., Li, Y., Gee, S., Dudley, A., Fant, J., Crosson, C. and Ma, J.X. (2002) Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: A possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. J. Biol. Chem., 277, 9492-9497.
44. Pebernard, S. and Iggo, R.D. (2004) Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation, 72, 103-111.
45. Scacheri, P.C., Rozenblatt-Rosen, O., Caplen, N.J., Wolfsberg, T.G., Umayam, L., Lee, J.C., Hughes, C.M., Shanmugam, K.S., Bhattacharjee, A., Meyerson, M. et al. (2004) Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc. Natl Acad. Sci. USA, 101, 1892-1897.