Using NMR solvent water relaxation to investigate metalloenzyme - Ligand binding interactions

Journal of Medicinal Chemistry

Volumn 53, Issue 2, 2010, Pages 867-875

  Leung, Ivanhoe K H ^a   Flashman, Emily ^a   Yeoh, Kar Kheng ^a   Schofield, Christopher J ^a   Claridge, Timothy D W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; MANGANESE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN CONTAINING ENZYME 2; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; IC 50; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE ANALYSIS; REACTION ANALYSIS;

DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ENZYMES; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; METALLOPROTEINS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; SOLVENTS; WATER;

EID: 77249083153     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901537q     Document Type: Article

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