Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC

Experimental Dermatology

Volumn 19, Issue 3, 2010, Pages 279-288

  Gourronc, Francoise A ^a   Robertson, McKaylee M ^a   Herrig, Annie K ^a   Lansdorp, Peter M ^b   Goldman, Frederick D ^c   Klingelhutz, Aloysius J ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Dyskeratosis; Keratinocytes; Telomerase; Telomeres; TERC

Indexed keywords

PROTEIN E6; PROTEIN E7; RETROVIRUS VECTOR; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE RNA COMPONENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CASE REPORT; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; DRUG MECHANISM; DYSKERATOSIS CONGENITA; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; MALE; SKIN FIBROBLAST; TELOMERE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADULT; BASE SEQUENCE; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; DNA PRIMERS; DYSKERATOSIS CONGENITA; ENZYME ACTIVATION; FEMALE; FIBROBLASTS; GENE EXPRESSION; HUMANS; KERATINOCYTES; MALE; MUTATION; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS E7 PROTEINS; REPRESSOR PROTEINS; RNA; TELOMERASE; TELOMERE; TRANSDUCTION, GENETIC; UP-REGULATION; YOUNG ADULT;

EID: 77149141072     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00916.x     Document Type: Article

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