Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes

Virology

Volumn 301, Issue 2, 2002, Pages 247-254

  Sprague, Daniel L ^a   Phillips, Stacia L ^a   Mitchell, Calista J ^a   Berger, Kristi L ^a   Lace, Michael ^b   Turek, Lubomir P ^b   Klingelhutz, Aloysius J ^a  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cervical; E6; Episomes; HPV 16; HTERT; Immortalization; Keratinocytes; Papillomavirus; Telomerase

Indexed keywords

PROTEIN E6; PROTEIN P53; RNA DIRECTED DNA POLYMERASE; TELOMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL CLONE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPISOME; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; UTERINE CERVIX; VIRUS REPLICATION; VIRUS TYPING;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPES; PAPILLOMAVIRUS;

EID: 0036402419     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1542     Document Type: Article

References (31)

1. Bieche, I., Nogues, C., Paradis, V., Olivi, M., Bedossa, P., Lidereau, R., and Vidaud, M. (2000). Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay. Clin. Cancer Res. 6(2), 452-459.
2. Cong, Y. S., and Bacchetti, S. (2000). Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J. Biol. Chem. 275(46), 35665-35668.
3. Dyson, N., Howley, P. M., Munger, K., and Harlow, E. (1989). The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243(4893), 934-937.
4. Flores, E. R., Allen-Hoffmann, B. L., Lee, D., Sattler, C. A., and Lambert, P. F. (1999). Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line. Virology 262(2), 344-354.
5. Frattini, M. G., Lim, H. B., and Laimins, L. A. (1996). In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. Proc. Natl. Acad. Sci. USA 93 (7), 3062-3067.
6. Gewin, L., and Galloway, D. A. (2001). E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc. J. Virol. 75(15), 7198-7201.
7. Halbert, C. L., Demers, G. W., and Galloway, D. A. (1992). The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. J. Virol. 66(4), 2125-2134.
8. Hawley-Nelson, P., Vousden, K. H., Hubbert, N. L., Lowy, D. R., and Schiller, J. T. (1989). HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 8, 3905-3910.
9. Howley, P. M. (1991). Role of human papillomavirus in human cancer. Cancer Res. 51, 5019-5022.
10. Kang, S. S., Kwon, T., Kwon, D. Y., and Do, S. I. (1999). Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274(19), 13085-13090.
11. Kilian, A., Bowtell, D. D. L., Abud, H. E., Hime, G. R., Venter, D. J., Keese, P. K., Duncan, E. L., Reddel, R. R., and Jefferson, R. A. (1997). Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet. 6(12), 2011-2019.
12. Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., and Klingelhutz, A. J. (1998). Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [see comments]. Nature 396(6706), 84-88.
13. Klingelhutz, A. J., Foster, S. A., and McDougall, J. K. (1996). Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380(6569), 79-82.
14. Li, H., Zhao, L. L., Funder, J. W., and Liu, J. P. (1997). Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. J. Biol. Chem. 272(27), 16729-16732.
15. Li, H., Zhao, L. L., Yang, Z., Funder, J. W., and Liu, J. P. (1998). Telomerase is controlled by protein kinase Calpha in human breast cancer cells. J. Biol. Chem. 273(50), 33436-33442.
16. Liu, J. P. (1999). Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J. 13(15), 2091-2104.
17. Meyers, C., Mayer, T. J., and Ozbun, M. A. (1997). Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA. J. Virol. 71(10), 7381-7386.
18. Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., and Weinberg, R. A. (1997). hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90(August 22), 785-795.
19. Munger, K., Phelps, W. C., Bubb, V., Howley, P. M., and Schlegel, R. (1989). The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63, 4417-4421.
20. Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., and Cech, T. R. (1997). Telomerase catalytic subunit homologs from fission yeast and human. Science 277(August 15), 955-959.
21. Nowak, J. A. (2000). Telomerase, cervical cancer, and human papillomavirus. Clin. Lab. Med. 20(2), 369-382.
22. Oh, S. T., Kyo, S., and Laimins, L. A. (2001). Telomerase activation by human papillomavirus type 16 E6 protein: Induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites. J. Virol. 75(12), 5559-5566.
23. Rapp, L., and Chen, J. (1998). The papillomavirus E6 proteins. Biochim. Biophys. Acta. 1378(1), F1-19.
24. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993). The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75(3), 495-505.
25. Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., and Howley, P. M. (1990). The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63(6), 1129-1136.
26. Snijders, P. J., van Duin, M., Walboomers, J. M., Steenbergen, R. D., Risse, E. K., Helmerhorst, T. J., Verheijen, R. H., and Meijer, C. J. (1998). Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: Strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA. Cancer Res. 58 (17), 3812-3818.
27. Steenbergen, R. D., Walboomers, J. M., Meijer, C. J., van der Raaij-Helmer, E. M., Parker, J. N., Chow, L. T., Broker, T. R., and Snijders, P. J. (1996). Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene 13(6), 1249-1257.
28. Takakura, M., Kyo, S., Sowa, Y., Wang, Z., Yatabe, N., Maida, Y., Tanaka, M., and Inoue, M. (2001). Telomerase activation by histone deacetylase inhibitor in normal cells. Nucleic Acids Res. 29(14), 3006-3011.
29. Veldman, T., Horikawa, I., Barrett, J. C., and Schlegel, R. (2001). Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J. Virol. 75(9), 4467-4472.
30. Werness, B. A., Levine, A. J., and Howley, P. M. (1990). Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248(4951), 76-79.
31. Wu, Y. J., Parker, L. M., Binder, N. E., Beckett, M. A., Sinard, J. H., Griffiths, C. T., and Rheinwald, J. G. (1982). The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell 31(3 Pt 2), 693-703.