Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients

British Journal of Haematology

Volumn 144, Issue 5, 2009, Pages 771-781

  Kirwan, Michael ^a   Beswick, Richard ^a   Vulliamy, Tom ^a   Nathwani, Amit C ^b   Walne, Amanda J ^a   Casimir, Colin ^c   Dokal, Inderjeet ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

Bone marrow failure; Dyskeratosis congenita; Gene therapy; Lymphocytes; Telomerase

Indexed keywords

LENTIVIRUS VECTOR; TELOMERASE; TERC ENZYME; UNCLASSIFIED DRUG;

ADULT; ARTICLE; B LYMPHOCYTE; CELL GROWTH; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; DYSKERATOSIS CONGENITA; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TELOMERE;

ADULT; B-LYMPHOCYTES; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; DYSKERATOSIS CONGENITA; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; LENTIVIRUS; MALE; RNA; T-LYMPHOCYTES; TELOMERASE; TELOMERE; TRANSDUCTION, GENETIC; YOUNG ADULT;

EID: 58849160878     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07516.x     Document Type: Article

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