Characterization of the thymic IL-7 niche in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 5, 2009, Pages 1512-1517

  Alves, Nuno L ^a,b   Goff, Odile Richard Le ^a,b   Huntington, Nicholas D ^a,b   Sousa, Ana Patricia ^a,b   Ribeiro, Vera S G ^a,b   Bordack, Allison ^a,b   Vives, Francina Langa ^a   Peduto, Lucie ^a   Chidgey, Ann ^c   Cumano, Ana ^a,b   Boyd, Richard ^c   Eberl, Gerard ^a   Di Santo, James P ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSTITUT PASTEUR   (France)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Aging; Cytokine; Development; Thymic epithelial cells; Thymus

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; STROMAL CELL DERIVED FACTOR 1; MESSENGER RNA; PHOTOPROTEIN; YELLOW FLUORESCENT PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; C57BL 6 MOUSE; CELL JUNCTION; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; FETUS DEVELOPMENT; GENE EXPRESSION; IN VIVO STUDY; INVOLUTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE; ANIMAL; BACTERIAL ARTIFICIAL CHROMOSOME; CELL CULTURE; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; POLYMERASE CHAIN REACTION; REPORTER GENE;

BACTERIA (MICROORGANISMS); MUS MUSCULUS;

ANIMALS; CELLS, CULTURED; CHROMOSOMES, ARTIFICIAL, BACTERIAL; EPITHELIAL CELLS; GENES, REPORTER; INTERLEUKIN-7; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMUS GLAND;

EID: 60849114415     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809559106     Document Type: Article

References (36)

1. Jameson SC, Hogquist KA, Bevan MJ (1995) Positive selection of thymocytes. Annu Rev Immunol 13:93-126.
2. Kyewski B, Klein L (2006) A central role for central tolerance. Annu Rev Immunol 24:571-606.
3. Anderson G, Moore NC, Owen JJ, Jenkinson EJ (1996) Cellular interactions in thymocyte development. Annu Rev Immunol 14:73-99.
4. Derbinski J, Schulte A, Kyewski B, Klein L (2001) Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2:1032-1039.
5. Petrie HT, Zuniga-Pflucker JC (2007) Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu Rev Immunol 25:649-679.
6. DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K (1995) Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA 92:377-381.
7. von Freeden-Jeffry U, et al. (1995) Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181:1519-1526.
8. Peschon JJ, et al. (1994) Early lymphocyte expansion isseverely impaired in interleukin 7 receptor-deficient mice. J Exp Med 180:1955-1960.
9. Fry TJ, Mackall CL (2002) Interleukin-7: from bench to clinic. Blood 99:3892-3904.
10. Link A,et al. (2007) Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 8:1255-1265.
11. Gray DH, et al. (2007) A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15. J Immunol 178:4956-4965.
12. Zamisch M, et al. (2005) Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J Immunol 174:60-67.
13. Napolitano LA, et al. (2001) Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7:73-79.
14. Aspinall R (2006) T cell development, ageing and Interleukin-7. Mech Ageing Dev 127:572-578.
15. Chidgey A, Dudakov J, Seach N, Boyd R (2007) Impact of niche aging on thymic regeneration and immune reconstitution. Semin Immunol 19:331-340.
16. Sparwasser T, Gong S, Li JY, Eberl G (2004) General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis38:39-50.
17. Jotereau F, Heuze F, Salomon-Vie V, Gascan H (1987) Cell kinetics in the fetal mouse thymus: precursorcell input, proliferation, and emigration. J Immunol 138:1026-1030.
18. Gray DH, et al. (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood1 08:3777-3785.
19. Anderson G, Lane PJ, Jenkinson EJ (2007) Generating intrathymic microenvironments to establish T-cell tolerance. Nat Rev Immunol 7:954-963.
20. Takeoka Y, et al. (1997) A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states. Dev Immunol 5:79-89.
21. Schluns KS, Kieper WC, Jameson SC, Lefrancois L (2000) Cytokine control of memory T-cell development and survival. Nat Immunol 1:426-432.
22. Anderson G, Jenkinson EJ (2001) Lymphostromal interactions in thymic development and function. Nat Rev Immunol 1:31-40.
23. Owen JJ, Ritter MA (1969) Tissue interaction in the development of thymus lymphocytes. J Exp Med 129:431-442.
24. Douagi I, Vieira P, Cumano A (2002) Lymphocyte commitment during embryonic development, in the mouse. Semin Immunol 14:361-369.
25. Nehls M, et al. (1996)Two genetically separable steps in the differentiation of thymic epithelium. Science 272:886-889.
26. Jenkinson EJ, Jenkinson WE, Rossi SW, Anderson G (2006) The thymus and T-cell commitment: the right niche for Notch? Nat Rev Immunol 6:551-555.
27. Gill J, Malin M, Hollander GA, Boyd R (2002) Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat Immunol 3:635-642.
28. Rossi SW, Jenkinson WE, Anderson G, Jenkinson EJ (2006) Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441:988-991.
29. Bleul CC, et al. (2006) Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441:992-996.
30. Di Santo JP,et al.(1999)The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. J Exp Med 189:563-574.
31. Friend SL, et al. (1994) A thymic stromal cell line supports in vitro development of surfaceIgM+ B cells and produces a novel growth factor affecting B and Tlineage cells. Exp Hematol 22:321-328.
32. Watanabe N, et al. (2005) Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatoryT cells in human thymus. Nature 436:1181-1185.
33. Liu YJ, et al. (2007) TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol 25:193-219.
34. Gray DH, Chidgey AP, Boyd RL (2002)Analysis of thymic stromal cell populations using flow cytometry. J Immunol Methods 260:15-28.
35. Samson SI, et al. (2003) GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NKcells. Immunity 19:701-711.
36. Eberl G, et al.(2004) Anessential function for the nuclear receptor RORgamma(t)inthe generation of fetal lymphoid tissue inducer cells. Nat Immunol 5:64-73.