Current state of coenzyme Q10 production and its applications

Applied Microbiology and Biotechnology

Volumn 85, Issue 6, 2010, Pages 1653-1663

  Jeya, Marimuthu ^a   Moon, Hee Jung ^a   Lee, Jeong Lim ^a   Kim, In Won ^a   Lee, Jung Kul ^a,b  

^a Konkuk University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Agrobacterium tumefaciens; Application; Coenzyme Q10; Metabolic engineering; Production

Indexed keywords

AGROBACTERIUM TUMEFACIENS; ANTIOXIDANT PROPERTIES; BENZOQUINONES; BIOPROCESSES; BIOSYNTHETIC ENZYMES; COFACTORS; COMMERCIAL PRODUCTIONS; ENERGY GENERATIONS; HUMAN DISEASE; ISOPRENOIDS; METABOLIC ENGINEERING; NUTRITIONAL SUPPLEMENTS; POTENTIAL APPLICATIONS; PRODUCTION INCREASE; REGULATORY MECHANISM; RESPIRATORY ELECTRONS;

ESCHERICHIA COLI; GENETIC ENGINEERING;

METABOLISM;

DIMETHYLALLYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPENTENYL DIPHOSPHATE; UBIDECARENONE;

BACTERIUM; BIOENGINEERING; ELECTRON; ENZYME; NUTRIENT UPTAKE;

ANTIOXIDANT ACTIVITY; CHEMICAL MUTAGENESIS; DIET SUPPLEMENTATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIAL DYSFUNCTION; ESCHERICHIA COLI; GENE OVEREXPRESSION; HUMAN; ISCHEMIA; LIPID PEROXIDATION; METABOLIC ENGINEERING; MICROORGANISM; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PSEUDOMONAS; REPERFUSION INJURY; RHODOBACTER SPHAEROIDES; SHORT SURVEY;

ANTIOXIDANTS; BIOREACTORS; DIETARY SUPPLEMENTS; ESCHERICHIA COLI; FERMENTATION; GENETIC ENGINEERING; HUMANS; INDUSTRIAL MICROBIOLOGY; RHIZOBIUM RADIOBACTER; UBIQUINONE;

AGROBACTERIUM TUMEFACIENS; ESCHERICHIA COLI;

EID: 76849094816     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2380-2     Document Type: Short Survey

References (89)

1. 10. US Patent 4,220,719
2. M Albrecht N Misawa G Sandmann 1999 Metabolic engineering of the terpenoid biosynthetic pathway of E. coli for production of the carotenoids b-carotene and zeaxanthin Biotechnol Lett 21 791 795 10.1023/A:1005547827380 1:CAS:528:DyaK1MXms1Oiurk%3D (Pubitemid 29445791)
3. 10 and vitamin E on the peroxidation of human low density lipoprotein subfractions Proc Natl Acad Sci U S A 92 9388 9391 10.1073/pnas.92.20.9388 1:CAS:528:DyaK2MXosVWlurY%3D
4. MN Ashby SY Kutsunai S Ackerman A Tzagoloff PA Edwards 1992 COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate: polyprenyltransferase J Biol Chem 267 4128 4136 1:CAS:528:DyaK3sXhsVansLo%3D
5. M Bader W Muse DP Ballou C Gassner JC Bardwell 1999 Oxidative protein folding is driven by the electron transport system Cell 98 217 227 10.1016/S0092-8674(00)81016-8 1:CAS:528:DyaK1MXltVOqtL8%3D (Pubitemid 29344909)
6. JL Barker JW Frost 2001 Microbial synthesis of p-hydroxybenzoic acid from glucose Biotechnol Bioeng 76 376 390 10.1002/bit.10160 1:CAS:528: DC%2BD3MXovFOnu7g%3D (Pubitemid 34015026)
7. M Battino E Ferri A Gorini R Federico Villa JF Rodriguez Huertas P Fiorella ML Genova G Lenaz M Marchetti 1990 Natural distribution and occurrence of coenzyme Q homologues Membr Biochem 9 179 190 10.3109/09687689009025839 1:CAS:528:DyaK38XitFWmt7c%3D
8. J Calles-Escandon M Cipolla 2001 Diabetes and endothelial dysfunction: a clinical perspective Endocr Rev 22 36 52 10.1210/er.22.1.36 1:STN:280: DC%2BD3M3isFCktA%3D%3D (Pubitemid 32187802)
9. X Chen DJ Zhang WT Qi SJ Gao ZL Xiu P Xu 2003 Microbial fed-batch production of 1,3-propanediol by Klebsiella pneumoniae under micro-aerobic conditions Appl Microbiol Biotechnol 63 143 146 10.1007/s00253-003-1369-5 1:CAS:528:DC%2BD3sXpsVOjt70%3D (Pubitemid 38139284)
10. 10 production in Agrobacterium tumefaciens ATCC4452 Process Biochem 40 3225 3229 10.1016/j.procbio.2005.03.038 1:CAS:528:DC%2BD2MXos1antLo%3D (Pubitemid 41595244)
11. 10 Appl Microbiol Biotechnol 68 9 15 10.1007/s00253-005-1946-x 1:CAS:528:DC%2BD2MXosVansbk%3D (Pubitemid 41202109)
12. 10 production in recombinant Escherichia coli expressing Agrobacterium tumefaciens dps gene J Biotechnol 144 1 64 69 10.1016/j.jbiotec.2009.04.010 10.1016/j.jbiotec.2009.04. 010 1:CAS:528:DC%2BD1MXhtlCntr%2FK
13. 10 in microbes Trends Biotechnol 25 514 521 10.1016/j.tibtech.2007.08.008 1:CAS:528:DC%2BD2sXht1KgsL3P (Pubitemid 350016417)
14. H Cocheme G Kelso A James M Ross J Trnka T Mahendiran J Asin-Cayuela F Blaikie A Manas C Porteous 2007 Mitochondrial targeting of quinones: therapeutic implications Mitochondrion 7 94 102 10.1016/j.mito.2007.02.007 (Pubitemid 46722288)
15. 10 J Am Coll Nutr 20 591 598 1:CAS:528:DC%2BD38XmvVKqtA%3D%3D
16. FL Crane P Navas 1997 The diversity of coenzyme Q function Mol Aspects Med 18 Suppl S1 S6 10.1016/S0098-2997(97)00016-2 1:CAS:528:DyaK2sXlvVakurs%3D (Pubitemid 27372914)
17. GD Daves Jr RF Muraca JS Whittick P Friis K Folkers 1967 Discovery of ubiquinones-1,-2,-3, and -4 and the nature of biosynthetic isoprenylation Biochemistry 6 2861 2866 10.1021/bi00861a029 1:CAS:528:DyaF2sXkvFOkurk%3D
18. L Ernster G Dallner 1995 Biochemical, physiological and medical aspects of ubiquinone function Biochim Biophys Acta 1271 195 204
19. WR Farmer JC Liao 2001 Precursor balancing for metabolic engineering of lycopene production in Escherichia coli Biotechnol Prog 17 57 61 10.1021/bp000137t 1:CAS:528:DC%2BD3cXotFeqsLk%3D (Pubitemid 32145375)
20. K Folkers P Langsjoen R Willis P Richardson LJ Xia CQ Ye H Tamagawa 1990 Lovastatin decreases coenzyme Q levels in humans Proc Natl Acad Sci U S A 87 8931 8934 10.1073/pnas.87.22.8931 1:CAS:528:DyaK3MXhsleqtQ%3D%3D (Pubitemid 120007623)
21. 10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells Int J Biochem Cell Biol 37 1208 1218 10.1016/j.biocel.2004.11.017 1:CAS:528:DC%2BD2MXitlChtb0%3D (Pubitemid 40381197)
22. J Grunler J Ericsson G Dallner 1994 Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins Biochim Biophys Acta 1212 259 277 1:STN:280:DyaK2c3lslKrsQ%3D%3D
23. SB Gu JM Yao QP Yuan PJ Xue ZM Zheng L Wang ZL Yu 2006 A novel approach for improving the productivity of ubiquinone-10 producing strain by low-energy ion beam irradiation Appl Microbiol Biotechnol 72 456 461 10.1007/s00253-005- 0283-4 1:CAS:528:DC%2BD28XotlChs7g%3D (Pubitemid 44273070)
24. 10 production in fed-batch culture of Agrobacterium tumefaciens Appl Microbiol Biotechnol 76 109 116 10.1007/s00253-007-0995-8 1:CAS:528:DC%2BD2sXosVSksL4%3D (Pubitemid 47194687)
25. 10 production by Agrobacterium tumefaciens Appl Microbiol Biotechnol 74 974 980 10.1007/s00253-006-0744-4 1:CAS:528:DC%2BD2sXjtVSqtLs%3D (Pubitemid 46434752)
26. Y Hamano T Dairi M Yamamoto T Kuzuyama N Itoh H Seto 2002 Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain Biosci Biotechnol Biochem 66 808 819 10.1271/bbb.66.808 1:CAS:528:DC%2BD38XjsFaksL8%3D
27. M Harker PM Bramley 1999 Expression of prokaryotic 1-deoxy-d-xylulose-5- phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis FEBS Lett 448 115 119 10.1016/S0014-5793(99)00360-9 1:CAS:528:DyaK1MXit1WrtLk%3D (Pubitemid 29151641)
28. 10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes Eur J Clin Nutr 56 1137 10.1038/sj.ejcn.1601464 1:CAS:528:DC%2BD38XosFOgtrk%3D (Pubitemid 35414801)
29. 10, a cutaneous antioxidant and energizer Biofactors 9 371 378 10.1002/biof.5520090238 1:CAS:528:DyaK1MXkt12mt7g%3D
30. 10 can prolong C. elegans lifespan by lowering oxidative stress Mech Ageing Dev 125 41 46 10.1016/j.mad.2003.10.002 1:CAS:528:DC%2BD3sXhtVWisrzM (Pubitemid 38045325)
31. AM James RA Smith MP Murphy 2004 Antioxidant and prooxidant properties of mitochondrial coenzyme Q Arch Biochem Biophys 423 47 56 10.1016/j.abb.2003.12. 025 1:CAS:528:DC%2BD2cXhtV2hsrY%3D (Pubitemid 38198212)
32. P Kaplan I Ku era V Dad k 1993 Effect of oxygen on ubiquinone-10 production by Paracoccus denitrificans Biotechnol Lett 15 1001 1002 10.1007/BF00129925 1:CAS:528:DyaK2cXislaiuw%3D%3D (Pubitemid 23324492)
33. M Kawamukai 2002 Biosynthesis, bioproduction and novel roles of ubiquinone J Biosci Bioeng 94 511 517 1:CAS:528:DC%2BD3sXhsVOns7c%3D
34. SW Kim JD Keasling 2001 Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production Biotechnol Bioeng 72 408 415 10.1002/1097-0290(20000220)72:4<408:: AID-BIT1003>3.0.CO;2-H 1:CAS:528:DC%2BD3MXhtVOht70%3D
35. 10 by the mutant strain, Agrobacterium tumefaciens BNQ 0605. Korean Patent 10-0458818
36. 10 production in recombinant Escherichia coli Appl Microbiol Biotechnol 72 982 985 10.1007/s00253-006-0359-9 1:CAS:528:DC%2BD28XhtVWhsr3F (Pubitemid 44477376)
37. JK Lee G Her SY Kim JH Seo 2004 Cloning and functional expression of the dps gene encoding decaprenyl diphosphate synthase from Agrobacterium tumefaciens Biotechnol Prog 20 51 56 10.1021/bp034213e 1:CAS:528:DC%2BD3sXotlaqsrc%3D (Pubitemid 38204171)
38. JK Lee DK Oh SY Kim 2007 Cloning and characterization of the dxs gene, encoding 1-deoxy-d-xylulose 5-phosphate synthase from Agrobacterium tumefaciens, and its overexpression in Agrobacterium tumefaciens J Biotechnol 128 555 566 10.1016/j.jbiotec.2006.11.009 1:CAS:528:DC%2BD2sXhtVCisb4%3D (Pubitemid 46156973)
39. G Lenaz R Fato S Di Bernardo D Jarreta A Costa ML Genova G Parenti Castelli 1999 Localization and mobility of coenzyme Q in lipid bilayers and membranes Biofactors 9 87 93 10.1002/biof.5520090202 1:CAS:528: DyaK1MXkt12msL4%3D
40. HK Lichtenthaler M Rohmer J Schwender 1997 Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants Physiologia Plantarum 101 643 652 10.1111/j.1399-3054.1997.tb01049.x 1:CAS:528:DyaK2sXnvFelur4%3D
41. BH Lipshutz P Mollard SS Pfeiffer W Chrisman 2002 A short, highly efficient synthesis of coenzyme Q(10) J Am Chem Soc 124 14282 14283 10.1021/ja021015v 1:CAS:528:DC%2BD38XosFWhtb8%3D (Pubitemid 35403731)
42. LM Lois N Campos SR Putra K Danielsen M Rohmer A Boronat 1998 Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis Proc Natl Acad Sci U S A 95 2105 2110 10.1073/pnas.95.5.2105 1:CAS:528:DyaK1cXhslejtbg%3D (Pubitemid 28145902)
43. VJ Martin DJ Pitera ST Withers JD Newman JD Keasling 2003 Engineering a mevalonate pathway in Escherichia coli for production of terpenoids Nat Biotechnol 21 796 802 10.1038/nbt833 1:CAS:528:DC%2BD3sXkvFertb4%3D (Pubitemid 36791399)
44. SF Martin I Buron JC Espinosa J Castilla JM Villalba JM Torres 2007 Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model Free Radic Biol Med 42 1723 1729 10.1016/j.freeradbiomed.2007.03.005 1:CAS:528:DC%2BD2sXkslCgsro%3D (Pubitemid 46617153)
45. 10. Patent EP 1 354 957 A1
46. 10. Kanegafuchi Chemical Industry, European Patent EP1391515
47. 10. Kaneka Corporation, Osaka, US Patent 6,762,037
48. PD Matthews ET Wurtzel 2000 Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase Appl Microbiol Biotechnol 53 396 400 10.1007/s002530051632 1:CAS:528:DC%2BD3cXivFWitbs%3D
49. 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects Proc Natl Acad Sci U S A 95 8892 8897 10.1073/pnas.95.15.8892 1:CAS:528:DyaK1cXkvFalt7s%3D (Pubitemid 28350585)
50. J Maury MA Asadollahi K Moller A Clark J Nielsen 2005 Microbial isoprenoid production: an example of green chemistry through metabolic engineering Adv Biochem Eng Biotechnol 100 19 51 1:CAS:528:DC%2BD2MXhtF2jsrnM
51. R Meganathan 2001 Ubiquinone biosynthesis in microorganisms FEMS Microbiol Lett 203 131 139 10.1111/j.1574-6968.2001.tb10831.x 1:CAS:528:DC%2BD3MXnt1ShsL8%3D
52. M Melzer L Heide 1994 Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli Biochim Biophys Acta 1212 93 102 1:CAS:528:DyaK2cXmslCqsb0%3D
53. 10 during treatment with HMG-CoA reductase inhibitors Mol Aspects Med 18 Suppl S137 S144 10.1016/S0098-2997(97)00014-9 1:CAS:528:DyaK2sXlvVarsr4%3D (Pubitemid 27372929)
54. MP Murphy 1997 Targeting bioactive compounds to mitochondria Trends Biotechnol 15 326 330 10.1016/S0167-7799(97)01068-8 1:CAS:528:DyaK2sXlt1CnsL8%3D (Pubitemid 27330629)
55. MP Murphy 2001 Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction Expert Opin Biol Ther 1 753 764 10.1517/14712598.1.5.753 1:CAS:528:DC%2BD3MXntVKhuro%3D
56. MP Murphy RA Smith 2000 Drug delivery to mitochondria: the key to mitochondrial medicine Adv Drug Deliv Rev 41 235 250 10.1016/S0169-409X(99) 00069-1 1:CAS:528:DC%2BD3cXhsVWqsb0%3D (Pubitemid 30122962)
57. 10 by Pseudomonas N842 Agric Biol Chem 42 1799 1800 1:CAS:528:DyaE1cXmtFWls78%3D
58. 10 Org Lett 4 261 264 10.1021/ol010263d 1:CAS:528:DC%2BD38XhsVWluw%3D%3D
59. BP Nichols JM Green 1992 Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase J Bacteriol 174 5309 5316 1:CAS:528:DyaK3sXksVCisrg%3D
60. K Okada K Suzuki Y Kamiya X Zhu S Fujisaki Y Nishimura T Nishino T Nakagawa M Kawamukai H Matsuda 1996 Polyprenyl diphosphate synthase essentially defines the length of the side chain of ubiquinone Biochim Biophys Acta 1302 217 223
61. K Okada T Kainou H Matsuda M Kawamukai 1998 Biological significance of the side chain length of ubiquinone in Saccharomyces cerevisiae FEBS Lett 431 241 244 10.1016/S0014-5793(98)00753-4 1:CAS:528:DyaK1cXks1Kqt7g%3D (Pubitemid 28334225)
62. K Okada T Kainou K Tanaka T Nakagawa H Matsuda M Kawamukai 1998 Molecular cloning and mutational analysis of the ddsA gene encoding decaprenyl diphosphate synthase from Gluconobacter suboxydans Eur J Biochem 255 52 59 10.1046/j.1432-1327.1998.2550052.x 1:CAS:528:DyaK1cXksFWkt7o%3D (Pubitemid 28316834)
63. N Orihara T Kuzuyama S Takahashi K Furihata H Seto 1998 Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus J Antibiot (Tokyo) 51 676 678 1:CAS:528:DyaK1cXltVyhur8%3D
64. 10 in health and disease Eur J Clin Nutr 53 764 770 10.1038/sj.ejcn.1600880 1:CAS:528:DyaK1MXnsVCru7c%3D
65. 10 in recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Gluconobacter suboxydans Appl Microbiol Biotechnol 67 192 196 10.1007/s00253-004-1743-y 1:CAS:528:DC%2BD2MXjtlarsLc%3D (Pubitemid 40591269)
66. WW Poon TQ Do BN Marbois CF Clarke 1997 Sensitivity to treatment with polyunsaturated fatty acids is a general characteristic of the ubiquinone-deficient yeast coq mutants Mol Aspects Med 18 Suppl S121 S127 10.1016/S0098-2997(97)00004-6 1:CAS:528:DyaK2sXlvVaku7Y%3D (Pubitemid 27372927)
67. M Rohmer M Knani P Simonin B Sutter H Sahm 1993 Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate Biochem J 295 Pt 2 517 524 1:CAS:528:DyaK3sXms1Kit74%3D
68. M Rohmer M Seemann S Horbach S Bringer-Meyer H Sahms 1996 Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis J Am Chem Soc 118 2564 2566 10.1021/ja9538344 1:CAS:528:DyaK28Xhtleitb8%3D (Pubitemid 26128045)
69. 10 production using Rhodopseudomonas spheroides Biotechnol Appl Biochem 16 19 22 1:CAS:528:DyaK38XlvFSiu7o%3D
70. 10 in early Parkinson disease: evidence of slowing of the functional decline Arch Neurol 59 1541 1550 10.1001/archneur.59.10.1541
71. 10 in patients with Parkinson's disease Exp Neurol 188 491 494 10.1016/j.expneurol.2004.05.003 1:CAS:528:DC%2BD2cXlsFyns7w%3D (Pubitemid 38891609)
72. RA Smith GF Kelso FH Blaikie CM Porteous EC Ledgerwood G Hughes AM James MF Ross J Asin-Cayuela HM Cocheme, et al. 2003 Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences Biochem Soc Trans 31 1295 1299 10.1042/BST0311295 1:CAS:528:DC%2BD3sXps12jsLY%3D
73. RAJ Smith G Kelso AM James MP Murphy 2004 Targeting coenzyme Q derivatives to mitochondria Methods Enzymol 382 45 67 10.1016/S0076-6879(04) 82003-2 1:CAS:528:DC%2BD2cXjtVWksL4%3D (Pubitemid 38240783)
74. B Soballe RK Poole 2000 Ubiquinone limits oxidative stress in Escherichia coli Microbiology 146 Pt 4 787 796 1:CAS:528:DC%2BD3cXislOjs7w%3D
75. K Suzuki K Okada Y Kamiya XF Zhu T Nakagawa M Kawamukai H Matsuda 1997 Analysis of the decaprenyl diphosphate synthase (dps) gene in fission yeast suggests a role of ubiquinone as an antioxidant J Biochem 121 496 505 1:CAS:528:DyaK2sXis1WitbY%3D
76. K Tabata SI Hashimoto 2004 Production of mevalonate by a metabolically-engineered E. coli Biotechnol Lett 26 1487 1491 10.1023/B:BILE.0000044449.08268.7d 1:CAS:528:DC%2BD2cXhtFSisrjF (Pubitemid 41440523)
77. S Takahashi T Nishino T Koyama 2003 Isolation and expression of Paracoccus denitrificans decaprenyl diphosphate synthase gene for production of ubiquinone-10 in Escherichia coli Biochem Eng J 16 183 190 10.1016/S1369- 703X(03)00035-4 1:CAS:528:DC%2BD3sXnt1CrsLY%3D (Pubitemid 37267447)
78. SR Thomas SB Leichtweis K Pettersson KD Croft TA Mori AJ Brown R Stocker 2001 Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice Arterioscler Thromb Vasc Biol 21 585 593 1:CAS:528:DC%2BD3MXivFCluro%3D
79. M Turunen J Olsson G Dallner 2004 Metabolism and function of coenzyme Q Biochim Biophys Acta 1660 171 199 10.1016/j.bbamem.2003.11.012 1:CAS:528:DC%2BD2cXntV2rtg%3D%3D (Pubitemid 38125244)
80. T Urakami M Hori-Okubo 1988 Production of isoprenoid compounds in the facultative methylotroph Protomonas extorquens J Ferment Technol 66 323 332 10.1016/0385-6380(88)90111-2 1:CAS:528:DyaL1cXkvV2ntrk%3D
81. GF Watts DA Playford KD Croft NC Ward TA Mori V Burke 2002 Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus Diabetologia 45 420 426 10.1007/s00125-001-0760-y 1:CAS:528: DC%2BD38XitVeisr4%3D (Pubitemid 34267365)
82. SH Yoon YM Lee JE Kim SH Lee JH Lee JY Kim YC Shin JD Keasling SW Kim 2006 Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate Biotechnol Bioeng 94 1025 1032 10.1002/bit.20912 1:CAS:528:DC%2BD28XnvF2lu7o%3D (Pubitemid 44221047)
83. SH Yoon JE Kim SH Lee HM Park MS Choi JY Kim SH Lee YC Shin JD Keasling SW Seon-Won Kim 2007 Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis Appl Microbiol Biotechnol 74 131 139 10.1007/s00253-006-0623-z 1:CAS:528:DC%2BD2sXhtVansL4%3D (Pubitemid 46183477)
84. H Yoshida Y Kotani K Ochiai K Araki 1998 Production of ubiquinone-10 using bacteria J Gen Appl Microbiol 44 19 26 10.2323/jgam.44.19 1:CAS:528:DyaK1cXjt1Klt70%3D (Pubitemid 28505119)
85. Y Yoshida M Hayakawa Y Habuchi E Niki 2006 Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio Biochim Biophys Acta 1760 1558 1568 1:CAS:528:DC%2BD28XhtVagtL3F
86. 10 production by Agrobacterium species J Ferment Technol 62 305 308
87. 10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway Metab Eng 8 406 416 10.1016/j.ymben.2006.05.002 1:CAS:528:DC%2BD28XoslOgtr8%3D (Pubitemid 44278727)
88. 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation-extraction process J Ind Microbiol Biotechnol 36 687 693 10.1007/s10295-009-0538-7 1:CAS:528:DC%2BD1MXkvValsLk%3D
89. X Zhu M Yuasa K Okada K Suzuki T Nakagawa M Kawamukai H Matsuda 1995 Production of ubiquinone in Escherichia coli by expression of various genes responsible for ubiquinone biosynthesis J Ferment Bioeng 79 493 495 10.1016/0922-338X(95)91268-A 1:CAS:528:DyaK2MXmtFShsb0%3D