Production of mevalonate by a metabolically-engineered Escherichia coli

Biotechnology Letters

Volumn 26, Issue 19, 2004, Pages 1487-1491

  Tabata, Kazuhiko ^a   Hashimoto, Shin Ichi ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Acetate; Fed batch fermentation; Mevalonate; Mevalonate pathway; Non mevalonate pathway

Indexed keywords

BIODEGRADATION; ENZYMES; ESCHERICHIA COLI; FERMENTATION; METABOLISM;

ACETATE; FED-BATCH FERMENTATION; MEVALONATE; MEVALONATE PATHWAY; NON-MEVALONATE PATHWAY;

BIOSYNTHESIS;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; PROKARYOTA;

ACETIC ACID DERIVATIVE; ACETOACETATE COENZYME A LIGASE; ACETOACETYL-COA SYNTHETASE; HMG-COA SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LONG CHAIN FATTY ACID COENZYME A LIGASE; MEVALONIC ACID; MULTIENZYME COMPLEX; RECOMBINANT PROTEIN;

ARTICLE; ENTEROCOCCUS FAECALIS; ENZYMOLOGY; ESCHERICHIA COLI; GENETIC ENHANCEMENT; GENETICS; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING;

ACETATES; COENZYME A LIGASES; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GENETIC ENHANCEMENT; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MEVALONIC ACID; MULTIENZYME COMPLEXES; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

EID: 21644488952     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1023/B:BILE.0000044449.08268.7d     Document Type: Article

References (15)

1. Choi J, Lee SY, Han K (1998) Cloning of the Alcaligenes latus polyhydroxyalkanonate biosynthesis genes and use of these genes for enhanced production of poly(3-hydroxybutyrate) in Escherichia coli. Appl. Environ. Microbiol. 64: 4897-4903.
2. Han MH, Yoon SS, Lee SY (2001) Proteome analysis of metabolically engineered Escherichia coli producing poly(3-hydroxybutyrate). J. Bacteriol. 183, 301-308.
3. Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner II JW, Lehnbeuter KR, Stauffacher CV, Gwynn MN, Rodwell VW (2002) Enterococcus faecalis acetoacetylcoenzyme A thiolase/3-hydroxy -3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. J. Bacteriol. 184: 2116-2122.
4. Hong SH, Park SJ, Moon SY, Park JP, Lee SY (2003) In silico prediction and validation of the importance of the Entner-Doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Escherichia coli. Biotechnol. Bioeng. 83: 854-863.
5. Kuzuyama T, Dairi T, Yamashita H, Shoji Y, Seto H (2004) Heterologous mevalonate production in Streptomyces lividans TK23. Biosci. Biotechnol. Biochem. 68: 931-934.
6. Martin VJJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat. Biotechnol. 21: 796-802.
7. Nishi T (1988) Studies on the maximization of foreign gene expression in Escherichia coli. PhD thesis, Tokyo University, Tokyo.
8. Otsuka K, Itoh M, Yoshizawa K (1973) On the determination of mevalonic acid by thin-layer and gas chromatography. Agric. Biol. Chem. 37: 1013-1017.
9. Rohmer M, Seemann M, Horbach S, Bringer-Meyer S, Sahm H (1996) Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis. J. Am. Chem. Soc. 118: 2564-2566.
10. Sambrook J, Fritsh EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
11. Sutherlin A, Hedl M, Sanchez-Neri B, Burgner II JW, Stauffacher CV Rodwell VW (2002) Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. J. Bacteriol. 184: 4065-4070.
12. Tamura G (1956) Hiochic acid, a new growth factor for Lactobacillus homohiochi and Lactobacillus heterohioch. J. Gen. Appl. Microbiol. 2: 431-434.
13. Wang F, Lee SY (1997) Production of poly(3-hydroxybutyrate) by fed-batch culture of filamentation-suppressed recombinant Escherichia coli. Appl. Environ. Microbiol. 63: 4765-1769.
14. Wolf ED, Hoffman HC, Aldrich EP, Skeggs RH, Wright DL, Folkers K (1956) β-Hydroxy-β-methyl-δ-valerolactone (divalonic acid), a new biological factor. J. Am. Chem. Soc. 78: 4498-4499.
15. Yamashita H, Shimada T, Sugiyama H EP392,346 (Oct. 17, 1990), (1991). Chem. Abstr. 114, 205566h.