Structural basis of West Nile virus neutralization by a therapeutic antibody

Nature

Volumn 437, Issue 7059, 2005, Pages 764-769

  Nybakken, Grant E ^a   Oliphant, Theodore ^a   Johnson, Syd ^b   Burke, Stephen ^b   Diamond, Michael S ^a   Fremont, Daved H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Analytical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOLOGICAL MEMBRANES; CATALYSIS; CONFORMATIONS; IMMUNOLOGY;

DENGUE; ENDOSOMAL MEMBRANES; HYDROPHOBIC FUSION; VIRUS NEUTRALIZATION;

VIRUSES;

ENVELOPE PROTEIN; EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN; VIRUS VACCINE;

MEDICINE;

ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS ADSORPTION; VIRUS INFECTION; VIRUS NEUTRALIZATION; WEST NILE FLAVIVIRUS; ADSORPTION; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY COMBINING SITE; BINDING SITE; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; EPITOPE MAPPING; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SERODIAGNOSIS; VERO CELL;

FLAVIVIRUS; JAPANESE ENCEPHALITIS VIRUS GROUP; WEST NILE VIRUS;

ADSORPTION; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BINDING SITES; BINDING SITES, ANTIBODY; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; EPITOPE MAPPING; GLYCOPROTEINS; IMMUNODOMINANT EPITOPES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PROTEIN CONFORMATION; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES; WEST NILE VIRUS;

EID: 26944454471     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature03956     Document Type: Article

References (30)

1. Granwehr, B. P. et al. West Nile virus: where are we now? Lancet Infect. Dis. 4, 547-556 (2004).
2. Bressanelli, S. et al. Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. EMBO J. 23, 728-738 (2004).
3. Modis, Y., Ogata, S., Clements, D. & Harrison, S. C. Structure of the dengue virus envelope protein after membrane fusion. Nature 427, 313-319 (2004).
4. Mukhopadhyay, S., Kuhn, R. J. & Rossmann, M. G. A structural perspective of the flavivirus life cycle. Nature Rev. Microbiol. 3, 13-22 (2005).
5. Diamond, M. S., Shrestha, B., Mehlhop, E., Sitati, E. & Engle, M. Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. Viral Immunol. 16, 259-278 (2003).
6. Wang, T. & Fikrig, E. Immunity to West Nile virus. Curr. Opin. Immunol. 16, 519-523 (2004).
7. Mukhopadhyay, S., Kim, B. S., Chipman, P. R., Rossmann, M. G. & Kuhn, R. J. Structure of West Nile virus. Science 302, 248 (2003).
8. Oliphant, T. et al. Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nature Med. 11, 522-530 (2005).
9. Sundberg, E. J. & Mariuzza, R. A. Molecular recognition in antibody-antigen complexes. Adv. Protein Chem. 61, 119-160 (2002).
10. Chao, G., Cochran, J. R. & Wittrup, K. D. Fine epitope mapping of antiepidermal growth factor receptor antibodies through random mutagenesis and yeast surface display. J. Mol. Biol. 342, 539-550 (2004).
11. Wu, K. P. et al. Structural basis of a flavivirus recognized by its neutralizing antibody: Solution structure of the domain III of the Japanese Encephalitis virus envelope protein. J. Biol. Chem. 278, 46007-46013 (2003).
12. Volk, D. E. et al. Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus. J. Biol. Chem. 279, 38755-38761 (2004).
13. Hiramatsu, K., Tadano, M., Men, R. & Lai, C. J. Mutational analysis of a neutralization epitope on the dengue type 2 virus (DEN2) envelope protein: monoclonal antibody resistant DEN2/DEN4 chimeras exhibit reduced mouse neurovirulence. Virology 224, 437-445 (1996).
14. Modis, Y., Ogata, S., Clements, D. & Harrison, S. C. A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc. Natl Acad. Sci. USA 100, 6986-6991 (2003).
15. Saphire, E. O. et al. Crystal structure of a neutralizing human IgG against HIV-1: a template for vaccine design. Science 293, 1155-1159 (2001).
16. Kuhn, R. J. et al. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell 108, 717-725 (2002).
17. Booy, F. P., Roden, R. B., Greenstone, H. L., Schiller, J. T. & Trus, B. L. Two antibodies that neutralize papillomavirus by different mechanisms show distinct binding patterns at 13 Å resolution. J. Mol. Biol. 281, 95-106 (1998).
18. Diamond, M. S., Shrestha, B., Marri, A., Mahan, D. & Engle, M. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. J. Virol. 77, 2578-2586 (2003).
19. Crill, W. D. & Roehrig, J. T. Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells. J. Virol. 75, 7769-7773 (2001).
20. Hung, S. L. et al. Analysis of the steps involved in Dengue virus entry into host cells. Virology 257, 156-167 (1999).
21. Halstead, S. B. & O'Rourke, E. J. Antibody-enhanced dengue virus infection in primate leukocytes. Nature 265, 739-741 (1977).
22. Gollins, S. W. & Porterfield, J. S. A new mechanism for the neutralization of enveloped viruses by antiviral antibody. Nature 321, 244-246 (1986).
23. Zolla-Pazner, S. Identifying epitopes of HIV-1 that induce protective antibodies. Nature Rev. Immunol. 4, 199-210 (2004).
24. Skehel, J. J. & Wiley, D. C. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu. Rev. Biochem. 69, 531-569 (2000).
25. Earp, L. J., Delos, S. E., Park, H. E. & White, J. M. The many mechanisms of viral membrane fusion proteins. Curr. Top. Microbiol. Immunol. 285, 25-66 (2005).
26. Chen, Y. et al. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nature Med. 3, 866-871 (1997).
27. Tassaneetrithep, B. et al. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J. Exp. Med. 197, 823-829 (2003).
28. Halstead, S. B. Neutralization and antibody-dependent enhancement of dengue viruses. Adv. Virus Res. 60, 421-467 (2003).
29. Tio, P. H., Jong, W. W. & Cardosa, M. J. Two dimensional VOPBA reveals laminin receptor (LAMRI) interaction with dengue virus serotypes 1, 2 and 3. Virol. J. 2, 25 (2005).
30. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).