Dissecting NGF Interactions with TrkA and p75 Receptors by Structural and Functional Studies of an Anti-NGF Neutralizing Antibody

Journal of Molecular Biology

Volumn 381, Issue 4, 2008, Pages 881-896

  Covaceuszach, Sonia ^a,b   Cassetta, Alberto ^c   Konarev, Petr V ^d,e   Gonfloni, Stefania ^b,f   Rudolph, Rainer ^g   Svergun, Dmitri I ^d,e   Lamba, Doriano ^c   Cattaneo, Antonino ^b,h  

^a Lay Line Genomics SpA   (Italy)

^b SISSA   (Italy)

^c CNR   (Italy)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY   (Russian Federation)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

^g MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^h EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

Author keywords

anti NGF antibody; docking; epitope mapping; NGF receptors; SAXS

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR ANTIBODY; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN RECEPTOR P75; NEUTRALIZING ANTIBODY; TROPOMYOSINE RECEPTOR KINASE A; TYROSINE KINASE RECEPTOR;

ARTICLE; EPITOPE MAPPING; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 48649089156     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.06.008     Document Type: Article

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