Pathogenesis of allergic airway inflammation

Current Allergy and Asthma Reports

Volumn 10, Issue 1, 2010, Pages 39-48

  Agrawal, Devendra K ^a   Shao, Zhifei ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allergic airway inflammation; Asthma; Asthma gene; Coagulation system; Cytotoxic T cell; Dendritic cell; Flt3 ligand; KCa3.1; Matrix metalloproteinase; T helper cell; T regulatory cell

Indexed keywords

ANTIASTHMATIC AGENT; ANTIGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CELL PROTEIN; CORTICOSTEROID; CYTOKINE; FINGOLIMOD; KIDNEY INJURY MOLECULE 1; MATRIX METALLOPROTEINASE; PROTEIN ADAM33; PROTEIN DPP10; PROTEIN GPRA; PROTEIN OPN3; PROTEIN ORMDL3; PROTEIN PDE4D; PROTEIN PHF11; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ASTHMA; ATOPY; BLOOD CLOTTING DISORDER; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; DENDRITIC CELL; DISEASE EXACERBATION; FIBRINOLYSIS; GENETIC SUSCEPTIBILITY; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; NONHUMAN; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; REVIEW; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ALLERGENS; ANIMALS; ASTHMA; DENDRITIC CELLS; FIBRINOLYSIS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC FACTORS; IMMUNOTHERAPY; INFLAMMATION; INTERLEUKINS; MICE; RESPIRATORY SYSTEM; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 76649112727     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-009-0081-7     Document Type: Review

References (97)

1. DH Broide 2001 Molecular and cellular mechanisms of allergic disease J Allergy Clin Immunol 108 S65 S71 10.1067/mai.2001.116436 11498675 (Pubitemid 32747850)
2. AM Vignola J Kips J Bousquet 2000 Tissue remodeling as a feature of persistent asthma J Allergy Clin Immunol 105 1041 1053 10.1067/mai.2000.107195 10856134 (Pubitemid 30418779)
3. MA Akdis S Trautmann I Klunker, et al. 2003 T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells FASEB J 17 1026 1035 10.1096/fj.02-1070com 12773485 (Pubitemid 36676389)
4. T Akkoc PJ de Koning B Ruckert, et al. 2008 Increased activation-induced cell death of high IFN-gamma-producing T(h)1 cells as a mechanism of T(h)2 predominance in atopic diseases J Allergy Clin Immunol 121 652 658 10.1016/j.jaci.2007.12.1171 18328893 This study reveals one of the mechanisms underlying the counteractive effect of Th1 and Th2 responses (Pubitemid 351323861)
5. J Louten K Boniface R de Waal Malefyt 2009 Development and function of Th17 cells in health and disease J Allergy Clin Immunol 123 1004 1011 10.1016/j.jaci.2009.04.003 19410689 This article comprehensively reviews the available information on Th17 cells
6. MC Veldhoen J Uyttenhove J van Snick, et al. 2008 Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset Nat Immunol 9 1341 1346 10.1038/ni.1659 18931678 This study demonstrates the pivotal role of TGF-β in the induction of Th9 cells
7. M Feili-Hariri DH Falkner PA Morel 2005 Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy J Leukoc Biol 78 656 664 10.1189/jlb.1104631 15961574 (Pubitemid 41292088)
8. JR Gordon F Li A Nayyar, et al. 2005 CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma J Immunol 175 1516 1522 16034089
9. Z Shao AS Bharadwaj HS McGee, et al. 2009 Fms-like tyrosine kinase 3 ligand increases a lung DC subset with regulatory properties in allergic airway inflammation J Allergy Clin Immunol 123 917 924 10.1016/j.jaci.2008.12.852 19348927 This study reveals the mechanisms of an Flt3-L-induced therapeutic effect in allergic airway inflammation and the presence of the functional distinct lung DC subsets in the mouse lung
10. AA Lighvani DM Frucht D Jankovic, et al. 2001 T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells Proc Natl Acad Sci U S A 98 15137 15142 10.1073/pnas.261570598 11752460 (Pubitemid 34013982)
11. S Furuta S Kagami T Tamachi, et al. 2008 Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation J Immunol 180 6656 6662 18453585
12. IM Djuretic D Levanon V Negreanu, et al. 2007 Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells Nat Immunol 8 145 153 10.1038/ni1424 17195845 (Pubitemid 46152645)
13. J Zhu L Guo CJ Watson, et al. 2001 Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion J Immunol 166 7276 7281 11390477
14. EJ Scheinman O Avni 2009 Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor J Biol Chem 284 3037 3048 10.1074/jbc.M807302200 19056736
15. T Tamachi H Takatori M Fujiwara, et al. 2009 STAT6 inhibits T-bet-independent Th1 cell differentiation Biochem Biophys Res Commun 382 751 755 10.1016/j.bbrc.2009.03.101 19324016
16. RG Jenner MJ Townsend I Jackson, et al. 2009 The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes Proc Natl Acad Sci U S A 106 17876 17881 10.1073/pnas.0909357106 19805038
17. XO Yang BP Pappu R Nurieva, et al. 2008 T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma Immunity 28 29 39 10.1016/j.immuni.2007.11.016 18164222
18. H Nakano M Yanagita MD Gunn 2001 CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells J Exp Med 194 1171 1178 10.1084/jem.194.8.1171 11602645 (Pubitemid 32995786)
19. HJ de Heer H Hammad T Soullie, et al. 2004 Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen J Exp Med 200 89 98 10.1084/jem.20040035 15238608 (Pubitemid 38924731)
20. T Koya H Matsuda K Takeda, et al. 2007 IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice J Allergy Clin Immunol 119 1241 1250 10.1016/j.jaci.2007.01.039 17353041 (Pubitemid 46654182)
21. SS Sung SM Fu CE Rose Jr, et al. 2006 A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins J Immunol 176 2161 2172 16455972
22. PJ Dunne B Moran RC Cummins KH Mills 2009 CD11c + CD8{alpha} + dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis J Immunol 183 400 410 10.4049/jimmunol.0900169 19542451
23. • Shao Z, Makinde TO, McGee HS, et al.: Flt3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation. J Immunol 2009 (in press). This study further reveals that the mechanisms underlying the Flt3-L-mediated therapeutic effect in allergic asthma also involve regulating lung DC migration and antigen uptake.
24. L Wu YJ Liu 2007 Development of dendritic-cell lineages Immunity 26 741 750 10.1016/j.immuni.2007.06.006 17582346 (Pubitemid 46908964)
25. IK Demedts GG Brusselle KY Vermaelen RA Pauwels 2005 Identification and characterization of human pulmonary dendritic cells Am J Respir Cell Mol Biol 32 177 184 10.1165/rcmb.2004-0279OC 15576669 (Pubitemid 40387643)
26. BJ Masten GK Olson CA Tarleton, et al. 2006 Characterization of myeloid and plasmacytoid dendritic cells in human lung J Immunol 177 7784 7793 17114449
27. F Schaumann M Muller A Braun, et al. 2008 Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma Am J Respir Crit Care Med 177 1307 1313 10.1164/rccm.200706-870OC 18388357 This study and that by Masten et al. [26] confirm the presence of DC subsets with a similar phenotype to blood DCs in the lungs. Functionally, they are actively involved in the development of allergic airway inflammation in humans (Pubitemid 351860907)
28. K Bratke M Lommatzsch P Julius, et al. 2007 Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge Thorax 62 168 175 10.1136/thx.2006.067793 16928719 (Pubitemid 46271724)
29. SZ Josefowicz A Rudensky 2009 Control of regulatory T cell lineage commitment and maintenance Immunity 30 616 625 10.1016/j.immuni.2009.04.009 19464984
30. MA Burchill J Yang C Vogtenhuber, et al. 2007 IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells J Immunol 178 280 290 17182565
31. EM Shevach DQ Tran TS Davidson J Andersson 2008 The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function Eur J Immunol 38 915 917 10.1002/eji.200738111 18395859
32. SG Zheng JH Wang W Stohl, et al. 2006 TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25+ regulatory cells J Immunol 176 3321 3329 16517699
33. J Kearley DS Robinson CM Lloyd 2008 CD4 + CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling J Allergy Clin Immunol 122 617 624 10.1016/j.jaci.2008.05.048 18672278
34. HS McGee DK Agrawal 2009 Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma Am J Respir Crit Care Med 180 211 225 10.1164/rccm.200809-1505OC 19447898 This study demonstrated the localization of inducible Tregs to the asthmatic lungs by adoptive transfer of green fluorescence protein-expressing inducible Tregs intravenously
35. P Stock T Kallinich O Akbari, et al. 2004 CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation Eur J Immunol 34 1817 1827 10.1002/eji.200324623 15214030 (Pubitemid 39256064)
36. JW Wells CJ Cowled A Giorgini, et al. 2007 Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration J Allergy Clin Immunol 119 226 234 10.1016/j.jaci.2006.09.004 17208606 (Pubitemid 46037803)
37. K Takeda SW Dow N Miyahara, et al. 2009 Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation J Immunol 183 181 190 10.4049/jimmunol.0803967 19542429
38. S Isogai A Athiviraham RS Fraser, et al. 2007 Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells Immunology 122 230 238 10.1111/j.1365-2567.2007.02632.x 17848163 (Pubitemid 47389951)
39. Miyahara N, Takeda K, Kodama T, et al.: Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J Immunol 2004, 172:2549-2558.
40. T Koya H Matsuda S Matsubara, et al. 2009 Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation Am J Respir Cell Mol Biol 41 271 280 10.1165/rcmb.2008-0256OC 19151321
41. SH Cho LA Stanciu ST Holgate SL Johnston 2005 Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma Am J Respir Crit Care Med 171 224 230 10.1164/rccm.200310-1416OC 15502111
42. W Weninger MA Crowley N Manjunath UH von Andrian 2001 Migratory properties of naive, effector, and memory CD8(+) T cells J Exp Med 194 953 966 10.1084/jem.194.7.953 11581317 (Pubitemid 32953264)
43. C Taube N Miyahara V Ott, et al. 2006 The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness J Immunol 176 3157 3164 16493075
44. T Koya N Miyahara K Takeda, et al. 2007 CD8+ T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4 + IL-4+ T cells J Immunol 179 2787 2796 17709492
45. JS Manavalan S Kim-Schulze L Scotto, et al. 2004 Alloantigen specific CD8 + CD28- FoxP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity Int Immunol 16 1055 1068 10.1093/intimm/dxh107 15226269 (Pubitemid 39136723)
46. K Siegmund B Ruckert N Ouaked, et al. 2009 Unique phenotype of human tonsillar and in vitro-induced FoxP3 + CD8+ T cells J Immunol 182 2124 2130 10.4049/jimmunol.0802271 19201865
47. E Xystrakis AS Dejean I Bernard, et al. 2004 Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation Blood 104 3294 3301 10.1182/blood-2004-03-1214 15271801 (Pubitemid 39507148)
48. M Gilliet YJ Liu 2002 Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells J Exp Med 195 695 704 10.1084/jem.20011603 11901196 (Pubitemid 34259715)
49. Maisi P, Sorsa T, Raulo SM, et al.: Increased matrix metalloproteinase (MMP)-9 in the airway after allergen challenge. Am J Respir Crit Care Med 2001, 164:1740; discussion 1740-1741.
50. DH Lim JY Cho M Miller, et al. 2006 Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice Am J Physiol Lung Cell Mol Physiol 291 L265 L271 10.1152/ajplung.00305.2005 16825657 (Pubitemid 44148111)
51. SJ McMillan J Kearley JD Campbell, et al. 2004 Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation J Immunol 172 2586 2594 14764732
52. DB Corry K Rishi J Kanellis, et al. 2002 Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency Nat Immunol 3 347 353 10.1038/ni773 11887181 (Pubitemid 34308622)
53. K Page JR Ledford P Zhou M Wills-Karp 2009 A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice J Immunol 183 3400 3408 10.4049/jimmunol.0900838 19667087
54. RL Warner NW Lukacs SD Shapiro, et al. 2004 Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen Am J Pathol 165 1921 1930 15579436
55. S Goswami P Angkasekwinai M Shan, et al. 2009 Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma Nat Immunol 10 496 503 10.1038/ni.1719 19329997
56. MF Sands PJ Ohtake SD Mahajan, et al. 2009 Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma Clin Immunol 130 186 198 10.1016/j.clim.2008.08.029 18955015
57. JJ McIntire DT Umetsu RH DeKruyff 2004 TIM-1, a novel allergy and asthma susceptibility gene Springer Semin Immunopathol 25 335 348 10.1007/s00281-003- 0141-3 15007635 (Pubitemid 38296941)
58. P Van Eerdewegh RD Little J Dupuis, et al. 2002 Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness Nature 418 426 430 10.1038/nature00878 12110844 (Pubitemid 34826843)
59. ID Sizing V Bailly P McCoon, et al. 2007 Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses J Immunol 178 2249 2261 17277130
60. H Jongepier HM Boezen A Dijkstra, et al. 2004 Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma Clin Exp Allergy 34 757 760 10.1111/j.1365-2222.2004.1938.x 15144468 (Pubitemid 38736791)
61. T Laitinen A Polvi P Rydman, et al. 2004 Characterization of a common susceptibility locus for asthma-related traits Science 304 300 304 10.1126/science.1090010 15073379 (Pubitemid 38452184)
62. YJ Tsai S Choudhry J Kho, et al. 2006 The PTGDR gene is not associated with asthma in 3 ethnically diverse populations J Allergy Clin Immunol 118 1242 1248 10.1016/j.jaci.2006.07.045 17157653 (Pubitemid 44854113)
63. M Allen A Heinzmann E Noguchi, et al. 2003 Positional cloning of a novel gene influencing asthma from chromosome 2q14 Nat Genet 35 258 263 10.1038/ng1256 14566338 (Pubitemid 37363180)
64. BE Himes GM Hunninghake JW Baurley, et al. 2009 Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene Am J Hum Genet 84 581 593 10.1016/j.ajhg.2009.04.006 19426955
65. J Galanter S Choudhry C Eng, et al. 2008 ORMDL3 gene is associated with asthma in three ethnically diverse populations Am J Respir Crit Care Med 177 1194 1200 10.1164/rccm.200711-1644OC 18310477 (Pubitemid 351860927)
66. JH White M Chiano M Wigglesworth, et al. 2008 Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation Hum Mol Genet 17 1890 1903 10.1093/hmg/ddn087 18344558 (Pubitemid 351865838)
67. O Hataji O Taguchi EC Gabazza, et al. 2002 Activation of protein C pathway in the airways Lung 180 47 59 10.1007/s004080000080 12105756 (Pubitemid 36002438)
68. SS Wagers RJ Norton LM Rinaldi, et al. 2004 Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness J Clin Invest 114 104 111 15232617
69. A Tanaka K Minoguchi X Chen, et al. 2008 Activated protein C attenuates leukocyte elastase-induced lung injury in mice Shock 30 153 158 10.1097/SHK.0b013e31815dd570 18628688
70. L Cohn C Herrick N Niu, et al. 2001 IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation J Immunol 166 2760 2767 11160342
71. TJ Huang PA MacAry P Eynott, et al. 2001 Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma J Immunol 166 207 217 11123294
72. SA Bryan BJ O'Connor S Matti, et al. 2000 Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2149 2153 10.1016/S0140-6736(00)03497-8 11191543 (Pubitemid 32047953)
73. JS Wild A Sigounas N Sur, et al. 2000 IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma J Immunol 164 2701 2710 10679111
74. B Ahrens C Gruber RD Rha, et al. 2009 BCG priming of dendritic cells enhances T regulatory and Th1 function and suppresses allergen-induced Th2 function in vitro and in vivo Int Arch Allergy Immunol 150 210 220 10.1159/000222673 19494518
75. JN Kline 2007 Immunotherapy of asthma using CpG oligodeoxynucleotides Immunol Res 39 279 286 10.1007/s12026-007-0083-2 17917072 (Pubitemid 47574894)
76. G Hansen G Berry RH DeKruyff DT Umetsu 1999 Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation J Clin Invest 103 175 183 10.1172/JCI5155 9916129
77. DA Randolph R Stephens CJ Carruthers DD Chaplin 1999 Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation J Clin Invest 104 1021 1029 10.1172/JCI7631 10525040
78. R Stephens SC Eisenbarth DD Chaplin 2002 T helper type 1 cells in asthma: friend or foe? Curr Opin Allergy Clin Immunol 2 31 37 10.1097/00130832- 200202000-00006 11964748
79. J Cui S Pazdziorko JS Miyashiro, et al. 2005 Th1-mediated airway hyperresponsiveness independent of neutrophilic inflammation J Allergy Clin Immunol 115 309 315 10.1016/j.jaci.2004.10.046 15696086 (Pubitemid 40215094)
80. T Sugimoto Y Ishikawa T Yoshimoto, et al. 2004 Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse J Exp Med 199 535 545 10.1084/jem.20031368 14970180 (Pubitemid 38233837)
81. N Hayashi T Yoshimoto K Izuhara, et al. 2007 T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production Proc Natl Acad Sci U S A 104 14765 14770 10.1073/pnas.0706378104 17766435 (Pubitemid 350003217)
82. RK Kumar DC Webb C Herbert PS Foster 2006 Interferon-gamma as a possible target in chronic asthma Inflamm Allergy Drug Targets 5 253 256 10.2174/187152806779010909 17168796
83. T Hayashi L Beck C Rossetto, et al. 2004 Inhibition of experimental asthma by indoleamine 2, 3-dioxygenase J Clin Invest 114 270 279 15254594
84. MD Cahalan KG Chandy 2009 The functional network of ion channels in T lymphocytes Immunol Rev 231 59 87 10.1111/j.1600-065X.2009.00816.x 19754890
85. G Cruse SM Duffy CE Brightling P Bradding 2006 Functional KCa3.1 K + channels are required for human lung mast cell migration Thorax 61 880 885 10.1136/thx.2006.060319 16809411 (Pubitemid 44570309)
86. I Grgic H Wulff I Eichler, et al. 2009 Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection Transplant Proc 41 2601 2606 10.1016/j.transproceed.2009.06. 025 19715983
87. DL Tharp DK Bowles 2009 The intermediate-conductance Ca2+ -activated K + channel (KCa3.1) in vascular disease Cardiovasc Hematol Agents Med Chem 7 1 11 10.2174/187152509787047649 19149539
88. K Toyama H Wulff KG Chandy, et al. 2008 The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans J Clin Invest 118 3025 3037 10.1172/JCI30836 18688283 This study carefully tested the effect and toxicity of the KCa3.1-specific blocker TRAM-34 in a murine model and provided solid preclinical evidence for the application of TRAM-34 in treating diseases related to KCa3.1 activity
89. MC Shepherd SM Duffy T Harris, et al. 2007 KCa3.1 Ca2+ activated K + channels regulate human airway smooth muscle proliferation Am J Respir Cell Mol Biol 37 525 531 10.1165/rcmb.2006-0358OC 17585114 (Pubitemid 350058183)
90. JH Edwan G Perry JE Talmadge DK Agrawal 2004 Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation J Immunol 172 5016 5023 15067083
91. JH Edwan DK Agrawal 2007 Flt3-ligand plasmid prevents the development of pathophysiological features of chronic asthma in a mouse model Immunol Res 37 147 159 10.1007/BF02685896 17695249 (Pubitemid 47344126)
92. AS Bharadwaj DK Agrawal 2007 Flt3 ligand generates morphologically distinct semimature dendritic cells in ovalbumin-sensitized mice Exp Mol Pathol 83 17 24 10.1016/j.yexmp.2006.09.007 17182033 (Pubitemid 46842958)
93. McGee HS, Edwan JH, Agrawal DK: Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lung of cockroach-sensitized and challenged mice. Am J Respir Cell Mol Biol 2009 May 15 (Epub ahead of print).
94. M Idzko H Hammad M van Nimwegen, et al. 2006 Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function J Clin Invest 116 2935 2944 10.1172/JCI28295 17080194 (Pubitemid 44684478)
95. AM Wolf K Eller R Zeiser, et al. 2009 The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo J Immunol 183 3751 3760 10.4049/jimmunol.0901011 19692647
96. P Gosset M Pichavant C Faveeuw, et al. 2005 Prostaglandin D2 affects the differentiation and functions of human dendritic cells: impact on the T cell response Eur J Immunol 35 1491 1500 10.1002/eji.200425319 15816013 (Pubitemid 40691431)
97. H Hammad M Kool T Soullie, et al. 2007 Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells J Exp Med 204 357 367 10.1084/jem.20061196 17283205 (Pubitemid 46294551)