Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation

Journal of Immunology

Volumn 183, Issue 1, 2009, Pages 181-190

  Takeda, Katsuyuki ^a   Dow, Steven W ^b   Miyahara, Nobuaki ^a   Kodama, Taku ^a   Koya, Toshiyuki ^a   Taube, Christian ^a   Joetham, Anthony ^a   Park, Jung Won ^a   Dakhama, Azzeddine ^a   Kedl, Ross M ^c   Gelfand, Erwin W ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ANTIGEN; CATIONIC LIPOSOME DNA COMPLEX; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; UNCLASSIFIED DRUG; VACCINE; AUTACOID; CATION; DNA VACCINE; EPITOPE; H 2KB PROTEIN, MOUSE; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LIPOSOME; METHACHOLINE CHLORIDE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA PROTEIN COMPLEX; EFFECTOR CELL; EOSINOPHILIA; FEMALE; GOBLET CELL; IMMUNIZATION; INFLAMMATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE TRANSFER; METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TRANSPLANTATION;

ADOPTIVE TRANSFER; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CATIONS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; H-2 ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; LIPOSOMES; METHACHOLINE CHLORIDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; VACCINES, DNA;

EID: 68949110237     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803967     Document Type: Article

References (41)

1. Eder, W., M. J. Ege, and E. von Mutius. 2006. The asthma epidemic. N. Engl. J. Med. 355: 2226-2235.
2. Milgrom, H. 2007. Unfulfilled expectations in asthma. Allergy Asthma Proc. 28: 111-113.
3. Anderson, H. R., R. Gupta, D. P. Strachan, and E. S. Limb. 2007. 50 years of asthma: UK trends from 1955 to 2004. Thorax 62: 85-90.
4. Murray, C. S., A. Woodcock, S. J. Langley, J. Morris, A. Custovic, and the IFWIN Study Team. 2006. Secondary prevention of asthma by the use of inhaled fluticasone propionate in wheezy infants (IFWIN): double-blind, randomised, controlled study. Lancet 368: 754-762.
5. van Rensen, E. L., J. K. Sont, C. E. Evertse, L. N. Willems, T. Mauad, P. S. Hiemstra, P. J. Sterk, and the AMPUL Study Group. 2005. Bronchial CD8 cell infiltrate and lung function decline in asthma. Am. J. Resp. Crit. Care Med. 172: 837-841.
6. McNairn, J. D., C. Ramos, and J. M. Portnoy. 2007. Outcome measures for asthma disease management. Curr. Opin. Allergy Clin. Immunol. 7: 231-235.
7. Roman, M., E. Martin-Orozco, J. S. Goodman, M. D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3: 849-854.
8. Santeliz, J. V., G. Van Nest, P. Traquina, E. Larsen, and M. Wills-Karp. 2002. Amb α1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J. Allergy Clin. Immunol. 109: 445-462.
9. Kline, J. N. 2007. Eat dirt: CpG DNA and immunomodulation of asthma. Proc. Am. Thorac. Soc. 4: 283-288.
10. Gauvreau, G. M., E. M. Hessel, L. P. Boulet, R. L. Coffman, and P. M. O'Byrne. 2006. Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses. Am. J. Resp. Crit. Care Med. 174: 15-20.
11. Higgins, D., J. D. Marshall, P. Traquina, G. Van Nest, and B. D. Livingston. 2007. Immunostimulatory DNA as a vaccine adjuvant. Expert Rev. Vaccines 6: 747-759.
12. Sakurai, H., K. Kawabata, F. Sakurai, S. Nakagawa, and H. Mizuguchi. 2008. Innate immune response induced by gene delivery vectors. Intl. J. Pharmacol. 354: 9-15.
13. Chen, W., W. Yan, and L. Huang. 2008. A simple but effective cancer vaccine consisting of an antigen and a cationic lipid. Cancer Immunol. Immunother. 57: 517-530.
14. Zaks, K., M. Jordan, A. Guth, K. Sellins, R. Kedl, A. Izzo, C. Bosio, and S. Dow. 2006. Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes. J. Immunol. 176: 7335-7345.
15. Kallinich, T., K. C. Beier, U. Wahn, P. Stock, and H. Hamelmann. 2007. T-cell co-stimulatory molecules: their role in allergic immune reactions. Eur. Resp. J. 29: 1246-1255.
16. O'Sullivan, S. M. 2005. Asthma death, CD8+ T cells, and viruses. Proc. Am. Thorac. Soc. 2: 162-165.
17. + T cells mediate inflammation and airway hyperresponsiveness. Nat. Med. 10: 865-869.
18. Wells, J. W., C. J. Cowled, A. Giorgini, D. M. Kemeny, and A. Noble. 2007. Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration. J. Allergy Clin. Immunol. 119: 226-234.
19. Sarantopoulos, S., L. Lu, and H. Cantor. 2004. Qa-1 restriction of CD8+ suppressor T cells. J. Clin. Invest. 114: 1218-1221. (Pubitemid 40385289)
20. + T cells. J. Immunol. 179: 2787-2796.
21. + T cells after primary but not secondary challenge. Am. J. Respir. Cell Mol. Biol. 33: 89-96.
22. Kitamura, K., K. Takeda, T. Koya, N. Miyahara, T. Kodama, A. Dakhama, T. Takai, A. Hirano, M. Tanimoto, M. Harada, and E. W. Gelfand. 2007. Critical role of the Fc receptor γ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J. Immunol. 178: 480-488.
23. Takeda, K., N. Miyahara, T. Kodama, C. Taube, A. Balhorn, A. Dakhama, K. Kitamura, A. Hirano, M. Tanimoto, and E. W. Gelfand. 2005. S- carboxymethylcysteine normalises airway responsiveness in sensitised and challenged mice. Eur. Respir. J. 26: 577-585.
24. Kedl, R. M., W. A. Rees, D. A. Hildeman, B. Schaefer, T. Mitchell, J. Kappler, and P. Marrack. 2000. T cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med. 192: 1105-1113.
25. Prescott, S. L. 2006. Maternal allergen exposure as a risk factor for childhood asthma. Curr. Allergy Asthma Rep. 6: 75-80.
26. Walter, J. M., and M. J. Holtzman. 2005. A centennial history of research on asthma pathogenesis. Am. J. Resp. Cell Mol. Biol. 32: 483-489.
27. von Mutius, E. 2007. Allergies, infections and the hygiene hypothesis-the epidemiological evidence. Immunobiology 212: 433-439.
28. Hessel, E. M., M. Chu, J. O. Lizcano, B. Chang, N. Herman, S. A. Kell, M. Wills-Karp, and R. L. Coffman. 2005. Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction. J. Exp. Med. 202: 1563-1573.
29. Burger, M. S., C. L. Zuleger, Q. Chu, X. Gao, L. G. Payne, and D. Chen. 2004. An antigen-independent but not antigen-specific Th1 response provides protection in the murine airway inflammation model. J. Allergy Clin. Immunol. 114: 1301-1308.
30. Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20: 709-760.
31. Dow, S. W., L. G. Fradkin, D. H. Liggitt, A. P. Willson, T. D. Heath, and T. A. Potter. 1999. Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously. J. Immunol. 163: 1552-1561.
32. Roda, J. M., R. Parihar, and W. E. Carson III. 2005. CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells. J. Immunol. 175: 1619-1627.
33. Yoshinaga, T., K. Yasuda, Y. Ogawa, M. Nishikawa, and Y. Takakura. 2007. DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. Immunology 120: 295-302.
34. Broide, D., and P. Sriramarao. 2001. Eosinophil trafficking to sites of allergic inflammation. Immunol. Rev. 179: 163-172.
35. Youn, C. J., M. Miller, K. J. Baek, J. W. Han, J. Nayar, S. Y. Lee, K. McElwain, S. McElwain, E. Raz, and D. H. Broide. 2004. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J. Immunol. 173: 7556-7564.
36. Takeda, K., A. Haczku, J. J. Lee, C. G. Irvin, and E. W. Gelfand. 2001. Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung. Am. J. Physiol. 281: L394-LL402.
37. Lack, G., H. Renz, J. Saloga, K. L. Bradley, J. E. Loader, D. Y. M. Leung, G. L. Larsen, and E. W. Gelfand. 1994. Nebulized by not parenteral IFN-γ decreases IgE production and normalizes airway function in a murine model of allergen sensitization. J. Immunol. 152: 25446-25454.
38. Flaishon, L., I. Topilski, D. Shoseyov, R. Hershkoviz, E. Fireman, Y. Levo, S. Marmor, and I. Shachar. 2002. Anti-inflammatory properties of low levels of IFN-γ. J. Immunol. 168: 3707-3711.
39. Yoshida, M., R. Leigh, K. Matsumoto, J. Wattie, R. Ellis, P. M. O'Byrne, and M. D. Inman. 2002. Effect of interferon-γ on allergic airway responses in interferon-gamma-deficient mice. Am. J. Resp. Crit. Care Med. 166: 451-456.
40. + T cell proliferation. PLoS ONE 3: e2404.
41. + T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J. Immunol. 172: 2549-2558.