Iron-binding activity in yeast frataxin entails a trade off with stability in the α1/β1 acidic ridge region

Biochemical Journal

Volumn 426, Issue 2, 2010, Pages 197-203

  Correia, Ana R ^a   Wang, Tao ^b,c   Craig, Elizabeth A ^b   Gomes, Cláudio M ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Frataxin; Iron sulfur cluster; Isu; Metallochaperone; Protein folding; Yfh1

Indexed keywords

A-THERMAL; CELLULAR FUNCTION; CONFORMATIONAL PLASTICITY; CONSERVED RESIDUES; FRATAXIN; FRIEDREICH'S ATAXIAS; IRON ATOMS; IRON BINDING; IRON-SULFUR CLUSTER; IRON-SULFUR CLUSTERS; MITOCHONDRIAL PROTEIN; NEGATIVE CHARGE; PROTEIN STABILITY; RECESSIVE DISORDER; SCAFFOLD PROTEIN; SHEET SURFACE; TRADE OFF;

PAPER SHEETING; PROTEIN FOLDING; SULFUR;

STABILITY;

FRATAXIN; IRON;

ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; IRON BINDING CAPACITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STABILITY; THERMOSTABILITY; YEAST;

AMINO ACID SEQUENCE; FRIEDREICH ATAXIA; HUMANS; IRON; IRON-BINDING PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE;

EID: 76549093324     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091612     Document Type: Article

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