Synthesis of 4,6-dideoxy-3-fluoro-2-keto-β-d-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities

Bioorganic Chemistry

Volumn 38, Issue 2, 2010, Pages 48-55

  Manta, Stella ^a   Tsoukala, Evangelia ^a   Tzioumaki, Niki ^a   Kiritsis, Christos ^a   Balzarini, Jan ^b   Komiotis, Dimitri ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Elimination reaction; Antitumor activity; Unsaturated dideoxy fluoro ketonucleosides

Indexed keywords

1 (2 O ACETYL 4 O BENZOYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)N4 BENZOYL CYTOSINE; 1 (2 O ACETYL 4 O BENZOYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (2 O ACETYL 4 O BENZYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2,4 DI O ACETYL 3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (2,4 DI O ACETYL 3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (2,4 DI O ACETYL 3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2,4 DI O ACETYL 3 DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)N4 BENZOYL CYTOSINE; 1 (2,4 DI O ACETYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)N4 BENZOYL CYTOSINE; 1 (2,4 DI O ACETYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (4 O ACETYL 3,6 DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (4 O BENZOYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)N4 BENZOYL CYTOSINE; 1 (4 O BENZOYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (4 O BENZYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (4,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 3 ENOPYRANOSYL 2 ULOSE) 5 FLUOROURACIL; 1 (4,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 3 ENOPYRANOSYL 2 ULOSE)N4 BENZOYL CYTOSINE; 1 (4,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 3 ENOPYRANOSYL 2 ULOSE)THYMINE; 1 (4,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 3 ENOPYRANOSYL 2 ULOSE)URACIL; 9 (2,4 DI O ACETYL 3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)N6 BENZOYL ADENINE; 9 (2,4 DI O ACETYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)N6 BENZOYL ADENINE; 9 (3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)N6 BENZOYL; 9 (4 O ACETYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)N6 BENZOYL ADENINE; 9 (4,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 3 ENOPYRANOSYL 2 ULOSE)N6 BENZOYL ADENINE; ADENINE DERIVATIVE; CYTOSINE DERIVATIVE; FLUOROURACIL DERIVATIVE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ACETYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DEACYLATION; DNA VIRUS; DRUG SYNTHESIS; ELIMINATION REACTION; HUMAN; HUMAN CELL; HYDROGENATION; IODINATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RNA VIRUS;

ADENINE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTOSINE; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HELA CELLS; HUMANS; MICE; NUCLEOSIDES; STEREOISOMERISM; THYMINE; URACIL;

RNA VIRUSES;

EID: 76549088188     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2009.11.001     Document Type: Article

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