Unsaturated fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-4-keto-β-d-glucopyranosyl derivatives of N4-benzoyl cytosine and N6-benzoyl adenine

European Journal of Medicinal Chemistry

Volumn 43, Issue 2, 2008, Pages 420-428

  Manta, Stella ^a   Agelis, George ^a   Botić, Tanja ^b   Cencič, Avrelija ^b   Komiotis, Dimitri ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY OF MARIBOR   (Slovenia)

Author keywords

Elimination reaction; Antitumor activity; Antiviral; Unsaturated fluoro ketonucleosides

Indexed keywords

1 (2,4,6 TRI O ACETYL 3 DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL) N4 BENZOYLCYTOSINE; 1 (3 DEOXY 3 FLUORO 6 O TRITYL BETA GLYCERO HEX 2 ENOPYRANOSYL 4 ULOSE) N4 BENZOYLCYTOSINE; 3 FLUORO 4 KETO BETA GLUCOPYRANOSYL DERIVATIVE; 9 (2,4,6 TRI O ACETYL 3 DEOXY 3 FLUORO BETA GLUCOPYRANOSYL) N6 BENZOYLADENINE; ADENINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOIC ACID DERIVATIVE; CYTOSINE; CYTOSINE DERIVATIVE; FLUOROURACIL; GLUCOPYRANOSIDE; HYDROXYL GROUP; NUCLEOSIDE; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DEACETYLATION; DEPROTECTION REACTION; DRUG SYNTHESIS; ELIMINATION REACTION; EVALUATION; GROWTH INHIBITION; MELANOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION KINETICS; PROTON NUCLEAR MAGNETIC RESONANCE; ROTAVIRUS; SILYLATION; STRUCTURE ACTIVITY RELATION;

ADENINE; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CYTOSINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; ROTAVIRUS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 38949104784     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.04.001     Document Type: Article

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